公开(公告)号：US06597952B1

公开(公告)日：2003-07-22

申请号：US09782347

申请日：2001-02-12

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A61N1362

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method for setting the parameters of an alert time window in an excitable tissue control device operative under a plurality of different cardiac conditions of a heart of a patient. The method includes providing said excitable tissue control device with a set of data including a plurality of sets of alert time window parameters. Each set of window parameters is uniquely associated with a different set of values of a plurality of cardiac condition defining parameters identifying one of the different cardiac conditions. Each set of window parameters includes at least a set of timing parameters usable for obtaining a beginning time point and an ending time point of the alert window. The sets of window parameters are obtained by processing data collected within a data collection session from a plurality of cardiac beats of the same patient under the different cardiac conditions.

摘要翻译： 一种用于在可患者组织控制装置中的警报时间窗口的参数设置方法，所述可激发组织控制装置在患者的心脏的多个不同心脏状态下工作。 该方法包括向所述可兴奋的组织控制装置提供包括多组警报时间窗参数的一组数据。 每套窗口参数与识别不同心脏状况之一的多个心脏病状定义参数的不同的值集合唯一地相关联。 每组窗口参数包括至少一组可用于获得警报窗口的开始时间点和结束时间点的定时参数。 窗口参数的集合通过在不同的心脏状况下处理来自同一患者的多个心跳的数据收集会话内收集的数据来获得。

公开(公告)号：US06459928B2

公开(公告)日：2002-10-01

申请号：US09768968

申请日：2001-01-24

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A01B50402

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： Apparatus and method for obtaining from a patient's heart data useful for on-line setting of the parameters of a detection time window in an excitable tissue control device. The method includes applying electrodes to a first cardiac site and a second cardiac site of a patient and electrically connecting the electrodes to a data collecting device. The device is then operated under a plurality of different cardiac conditions to obtain a plurality of different histogram data sets. Each histogram data set represents a cumulative time distribution histogram of cardiac depolarization events detected at the second cardiac site in a plurality of cardiac beats. Each histogram data set is defined by a plurality of histogram parameters having values indicative of the cardiac conditions common to the plurality of cardiac beats used to obtain the histogram data set. The histogram parameters include a sensitivity level parameter representing the sensitivity level used for detecting the cardiac depolarization events of the plurality of cardiac beats at the second cardiac site. Another histogram parameter represents the range of values of the beat to beat time interval for the beats who's data is included in the histogram data set. Another histogram parameter has values indicating if the beats who's data is included in the histogram data set were acquired under conditions in which the delivery of non-excitatory ETC signals substantially affected or did not substantially affect the velocity of propagation of depolarization waves in the myocardium. Another histogram parameter, which may be used in devices having pacing capability has values indicating whether the beats who's data is included in the histogram data set are paced beats or non-paced beats. The histogram data sets are processed for computing a set of data usable for on-line setting of the parameters of a detection time window. This set of data may then be used for operating an implanted or external ETC device operatively connected to the electrodes.

公开(公告)号：US06424866B1

公开(公告)日：2002-07-23

申请号：US09841891

申请日：2001-04-25

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Yoav Kimchy

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Yoav Kimchy

IPC分类号： A61N136

摘要： A method and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of a portion of the heart are disclosed. The method includes the steps of applying electrodes to a plurality of cardiac sites, sensing electrical activity in a first cardiac site through a first electrode for detecting a first electrical depolarization event within a beat cycle, sensing electrical activity in a second cardiac site through a second electrode for detecting a second electrical depolarization event within the beat cycle, and applying a non-excitatory signal to the heart at or near at least the second cardiac site through at least one of the electrodes in response to detecting the second electrical depolarization event within an alert window period. The alert window period starts at a first delay from the time of detection of the first electrical depolarization event and has a first duration. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The method may include steps for reducing the probability of delivering of improperly timed non-excitatory signals due to electrical noise and/or ectopic beats and may also include steps for preventing delivery of multiple non-excitatory signals at or near the second cardiac site within a single cardiac beat cycle. Preferably, the first cardiac site is located about the right ventricle or the right atrium of the heart and the second cardiac site is located about the left ventricle of the heart. The devices may also be adapted for pacing the heart and/or for delivering defibrilation signals to the heart.

公开(公告)号：US06993391B2

公开(公告)日：2006-01-31

申请号：US10446567

申请日：2003-05-28

申请人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

发明人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

IPC分类号： A61N1/18

CPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/306 ,  A61N1/326 ,  A61N1/36007

摘要： Apparatus is provided for treating a condition such as obesity. The apparatus includes a set of one or more electrodes, which are adapted to be applied to one or more respective sites in a vicinity of a body of a stomach of a patient. A control unit is adapted to drive the electrode set to apply to the body of the stomach a signal, configured such that application thereof increases a level of contraction of muscle tissue of the body of the stomach, and decreases a cross-sectional area of a portion of the body of the stomach for a substantially continuous period greater than about 3 seconds.

公开(公告)号：US06600953B2

公开(公告)日：2003-07-29

申请号：US09734358

申请日：2000-12-11

申请人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

发明人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

IPC分类号： A61N136

CPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/306 ,  A61N1/326 ,  A61N1/36007

摘要： Apparatus is provided for treating a condition such as obesity. The apparatus includes a set of one or more electrodes, which are adapted to be applied to one or more respective sites in a vicinity of a body of a stomach of a patient. A control unit is adapted to drive the electrode set to apply to the body of the stomach a signal, configured such that application thereof increases a level of contraction of muscle tissue of the body of the stomach, and decreases a cross-sectional area of a portion of the body of the stomach for a substantially continuous period greater than about 3 seconds.

公开(公告)号：US06263242B1

公开(公告)日：2001-07-17

申请号：US09276460

申请日：1999-03-25

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky

IPC分类号： A61N136

CPC分类号： A61N1/3627 ,  A61B5/0452 ,  A61N1/368 ,  A61N1/3962

摘要： A method and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of a portion of the heart. The method includes the steps of applying electrodes to a plurality of cardiac sites, sensing electrical activity in a first cardiac site through a first electrode for detecting a first electrical depolarization event within a beat cycle, sensing electrical activity in a second cardiac site through a second electrode for detecting a second electrical depolarization event within the beat cycle, and applying a non-excitatory signal to the heart at or near at least the second cardiac site through at least one of the electrodes in response to detecting the second electrical depolarization event within an alert window period. The alert window period starts at a first delay from the time of detection of the first electrical depolarization event and has a first duration. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The method may include steps for reducing the probability of delivering of improperly timed non-excitatory signals due to electrical noise and/or ectopic beats and may also include steps for preventing delivery of multiple non-excitatory signals at or near the second cardiac site within a single cardiac beat cycle. Preferably, the first cardiac site is located about the right ventricle or the right atrium of the heart and the second cardiac site is located about the left ventricle of the heart. The devices may also be adapted for pacing the heart and/or for delivering defibrillation signals to the heart.

摘要翻译： 用于定时递送非兴奋性信号以改善心脏部分心肌收缩力的方法和装置。 该方法包括以下步骤：将电极施加到多个心脏部位，通过第一电极感测第一心脏位点中的电活动，以检测搏动周期内的第一电去极化事件，通过第二电极感测第二心脏位点中的电活动 电极，用于检测所述拍摄周期内的第二电去极化事件，以及响应于检测到所述第二电去极化事件中的至少一个所述电极中的至少第二心脏位点处或附近的心脏施加非兴奋性信号 警报窗口期间。 警报窗口期间从检测到第一电去极化事件的时间开始，并且具有第一持续时间。 从第二次电去极化事件的检测时间开始延迟非兴奋性信号的施加。 该方法可以包括用于降低由于电噪声和/或异位搏动而递送不正确定时的非兴奋性信号的可能性的步骤，并且还可以包括用于防止在第一心脏位点处或附近传递多个非兴奋性信号的步骤 单心跳搏动循环。 优选地，第一心脏位点位于心脏的右心室或右心房周围，并且第二心脏部位位于心脏的左心室周围。 所述装置还可以适于起搏心脏和/或用于将除颤信号输送到心脏。

公开(公告)号：US06233487B1

公开(公告)日：2001-05-15

申请号：US09338649

申请日：1999-06-23

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A61N1362

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method for setting the parameters of an alert time window in an excitable tissue control device operative under a plurality of different cardiac conditions of a heart of a patient. The method includes providing said excitable tissue control device with a set of data including a plurality of sets of alert time window parameters. Each set of window parameters is uniquely associated with a different set of values of a plurality of cardiac condition defining parameters identifying one of the different cardiac conditions. Each set of window parameters includes at least a set of timing parameters usable for obtaining a beginning time point and an ending time point of the alert window. The sets of window parameters are obtained by processing data collected within a data collection session from a plurality of cardiac beats of the same patient under the different cardiac conditions. The methods updates for each current beat cycle the values of a plurality of cardiac condition defining variables corresponding to said cardiac condition defining parameters, automatically selects a current set of alert time window parameters based on the current values of the cardiac condition defining variables, starts and terminates the alert time window based on the time of detecting a first depolarization event at a first cardiac site, detects within the duration of the alert window a second depolarization event at a second cardiac site, and triggers the delivery of a delayed non-excitatory excitable tissue control signal at the second cardiac site based on the time of detection of the second depolarization event. The different cardiac conditions include different beat cycle lengths, and may include beats which are or are not influenced by prior application of ETC signals to the heart and, where relevant, naturally and artificially paced beats. The alert window parameters may include an event detection sensitivity level parameter. Implantable and external devices are describe which are adapted for implementing the disclosed method.

公开(公告)号：US06223072B1

公开(公告)日：2001-04-24

申请号：US09328068

申请日：1999-06-08

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A61B50456

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： Apparatus and method for obtaining from a patient's heart data useful for on-line setting of the parameters of a detection time window in an excitable tissue control device. The method includes applying electrodes to a first cardiac site and a second cardiac site of a patient and electrically connecting the electrodes to a data collecting device. The device is then operated under a plurality of different cardiac conditions to obtain a plurality of different histogram data sets. Each histogram data set represents a cumulative time distribution histogram of cardiac depolarization events detected at the second cardiac site in a plurality of cardiac beats. Each histogram data set is defined by a plurality of histogram parameters having values indicative of the cardiac conditions common to the plurality of cardiac beats used to obtain the histogram data set. The histogram parameters include a sensitivity level parameter representing the sensitivity level used for detecting the cardiac depolarization events of the plurality of cardiac beats at the second cardiac site. Another histogram parameter represents the range of values of the beat to beat time interval for the beats who's data is included in the histogram data set. Another histogram parameter has values indicating if the beats who's data is included in the histogram data set were acquired under conditions in which the delivery of non-excitatory ETC signals substantially affected or did not substantially affect the velocity of propagation of depolarization waves in the myocardium. Another histogram parameter, which may be used in devices having pacing capability has values indicating whether the beats who's data is included in the histogram data set are paced beats or non-paced beats. The histogram data sets are processed for computing a set of data usable for on-line setting of the parameters of a detection time window. This set of data may then be used for operating an implanted or external ETC device operatively connected to the electrodes.

公开(公告)号：US06370430B1

公开(公告)日：2002-04-09

申请号：US09572482

申请日：2000-05-16

申请人： Yuval Mika ,  Ziv Belsky

发明人： Yuval Mika ,  Ziv Belsky

IPC分类号： A61N136

CPC分类号： A61N1/3962 ,  A61B5/0452 ,  A61B5/7217 ,  A61B5/7264 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/368

摘要： A method and device for controlling the delivery of cardiac contractility modulating signals to the heart are disclosed. The method includes applying electrodes to a heart, sensing electrical activity in a first cardiac chamber and in at least a second cardiac chamber to detect events within a cardiac beat cycle and applying a cardiac contractility modulating signal to the heart at or about the first cardiac chamber in response to detecting an event within an alert window time interval. The applying of the cardiac contractility modulating signal is inhibited in response to detecting one or more inhibitory events occurring within specific time intervals defined within a current beat cycle. The method also includes the ignoring of events associated with expected electrical artifact signals if they occur within the duration of specified time intervals, to increase the therapy efficacy. The artifact signals may be associated with pacing of a cardiac chamber or with detected far field sensed electrical artifacts due to intrinsic chamber activation. The timing of the various time intervals and of the cardiac contractility signal may be computed on a beat by beat basis by utilizing a plurality of parameter sets stored in the device and the timing of events detected in each beat cycle. A method for determining and setting the parameter sets in a test session is disclosed.

摘要翻译： 公开了一种用于控制心脏收缩力调节信号传送到心脏的方法和装置。 该方法包括将电极施加到心脏，感测第一心室和第二心室中的电活动，以检测心搏周期内的事件，并将心脏收缩调节信号施加于第一心室或其周围的心脏 响应于检测到警报窗口时间间隔内的事件。 响应于检测在当前搏动周期内定义的特定时间间隔内发生的一个或多个抑制事件，抑制心肌收缩调节信号的应用。 该方法还包括忽略与预期的电假象信号相关联的事件，如果它们在指定时间间隔的持续时间内发生，以增加治疗功效。 神经信号可能与心室的起搏相关联，或与由于内腔活化而被检测到的远场感测到的电假象有关。 可以通过利用存储在设备中的多个参数集和在每个拍子周期中检测到的事件的定时，以搏动为基础计算各种时间间隔和心脏收缩信号的定时。 公开了一种在测试会话中确定和设置参数集的方法。

公开(公告)号：US07512442B2

公开(公告)日：2009-03-31

申请号：US11260971

申请日：2005-10-28

申请人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

发明人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

IPC分类号： A61N1/36

CPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/306 ,  A61N1/326 ,  A61N1/36007

摘要： Apparatus is provided for treating a condition such as obesity. The apparatus includes a set of one or more electrodes, which are adapted to be applied to one or more respective sites in a vicinity of a body of a stomach of a patient. A control unit is adapted to drive the electrode set to apply to the body of the stomach a signal, configured such that application thereof increases a level of contraction of muscle tissue of the body of the stomach, and decreases a cross sectional area of a portion of the body of the stomach for a substantially continuous period greater than about 3 seconds.

摘要翻译： 提供用于治疗诸如肥胖症的病症的装置。 该装置包括一组一个或多个电极，其适于施加到患者的胃的身体附近的一个或多个相应部位。 控制单元适于驱动电极组以向胃体施加信号，该信号被配置为使得其应用增加胃体的肌肉组织的收缩水平，并且减小部分的横截面面积 的胃大体连续的时间大于约3秒。