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1.Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases 失效
标题翻译: 使用环氧合酶抑制剂治疗神经变性疾病公开(公告)号:US5840746A
公开(公告)日:1998-11-24
申请号:US926291
申请日:1997-09-05
申请人: Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
发明人: Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
IPC分类号: A61K31/10 , A61K31/341 , A61K31/381 , A61K31/425 , A61K31/426 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07C323/49 , C07D209/26 , C07D275/02 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04 , A61K31/38 , A61K31/27 , A61K31/34
CPC分类号: C07D275/02 , A61K31/10 , A61K31/341 , A61K31/381 , A61K31/425 , A61K31/426 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07C323/49 , C07D209/26 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04 , C07C2101/08 , C07C2102/08
摘要: The present invention provides a method of treating a neurodegenerative disease and in particular Alzheimers disease which comprises administering to a human in need thereof a therapeutically effective amount of a non-steroid COX-II inhibitor. Although a wide range of COX-II inhibitors may be employed but it is preferred to employ compounds of the Formula I: ##STR1##
摘要翻译: 本发明提供治疗神经变性疾病,特别是阿尔茨海默病的方法,其包括向有需要的人施用治疗有效量的非类固醇COX-II抑制剂。 尽管可以使用大范围的COX-II抑制剂,但优选使用式I的化合物:
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公开(公告)号:US5767291A
公开(公告)日:1998-06-16
申请号:US738144
申请日:1996-10-25
申请人: Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
发明人: Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
摘要: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
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3.Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases 失效
标题翻译: 使用环氧合酶抑制剂治疗神经变性疾病公开(公告)号:US06486194B2
公开(公告)日:2002-11-26
申请号:US09796211
申请日:2001-02-28
申请人: Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
发明人: Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
IPC分类号: A61K3138
CPC分类号: C07D275/02 , A61K31/10 , A61K31/341 , A61K31/381 , A61K31/425 , A61K31/426 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07C2601/08 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04
摘要: The present invention provides a method of treating a neurodegenerative disease and in particular Alzheimers disease which comprises administering to a human in need thereof a therapeutically effective amount of a non-steroid COX-II inhibitor. Although a wide range of COX-II inhibitors may be employed but it is preferred to employ compounds of the Formula I:
摘要翻译: 本发明提供治疗神经变性疾病,特别是阿尔茨海默病的方法,其包括向有需要的人施用治疗有效量的非类固醇COX-II抑制剂。 尽管可以使用大范围的COX-II抑制剂,但优选使用式I的化合物:
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公开(公告)号:US5710140A
公开(公告)日:1998-01-20
申请号:US699142
申请日:1996-08-16
申请人: Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
发明人: Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
IPC分类号: C07D333/06 , A61K31/00 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/18 , A61K31/19 , A61K31/255 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/425 , A61K31/426 , A61K31/66 , A61P1/00 , A61P1/02 , A61P1/04 , A61P7/04 , A61P11/06 , A61P15/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/16 , A61P35/00 , A61P43/00 , C07C20060101 , C07C13/08 , C07C13/10 , C07C305/18 , C07C307/02 , C07C311/15 , C07C311/16 , C07C311/29 , C07C311/37 , C07C311/46 , C07C311/49 , C07C311/51 , C07C317/10 , C07C317/24 , C07C323/29 , C07D207/26 , C07D207/333 , C07D207/38 , C07D207/444 , C07D207/448 , C07D275/02 , C07D277/02 , C07D277/22 , C07D277/24 , C07D277/26 , C07D307/33 , C07D307/38 , C07D307/58 , C07D309/32 , C07D333/04 , C07D333/12 , C07D333/16 , C07D333/18 , C07D333/24 , C07D333/38 , C07D333/40 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D503/04 , C07F9/40 , C07F9/547 , C07F9/572 , C07F9/6506 , C07F9/653 , C07F9/6539 , C07F9/655 , A61K31/675 , C07F9/02
CPC分类号: C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04 , C07C2101/08
摘要: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号:US5550142A
公开(公告)日:1996-08-27
申请号:US438130
申请日:1995-05-08
申请人: Yves Ducharme , Jacques Y. Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
发明人: Yves Ducharme , Jacques Y. Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
IPC分类号: C07D333/06 , A61K31/00 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/18 , A61K31/19 , A61K31/255 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/425 , A61K31/426 , A61K31/66 , A61P1/00 , A61P1/02 , A61P1/04 , A61P7/04 , A61P11/06 , A61P15/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/16 , A61P35/00 , A61P43/00 , C07C20060101 , C07C13/08 , C07C13/10 , C07C305/18 , C07C307/02 , C07C311/15 , C07C311/16 , C07C311/29 , C07C311/37 , C07C311/46 , C07C311/49 , C07C311/51 , C07C317/10 , C07C317/24 , C07C323/29 , C07D207/26 , C07D207/333 , C07D207/38 , C07D207/444 , C07D207/448 , C07D275/02 , C07D277/02 , C07D277/22 , C07D277/24 , C07D277/26 , C07D307/33 , C07D307/38 , C07D307/58 , C07D309/32 , C07D333/04 , C07D333/12 , C07D333/16 , C07D333/18 , C07D333/24 , C07D333/38 , C07D333/40 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D503/04 , C07F9/40 , C07F9/547 , C07F9/572 , C07F9/6506 , C07F9/653 , C07F9/6539 , C07F9/655
CPC分类号: C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04 , C07C2101/08
摘要: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译: 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。 本发明还包括用于治疗环氧合酶-2介导的疾病的某些药物组合物,其包含式I化合物。
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公开(公告)号:US5536752A
公开(公告)日:1996-07-16
申请号:US436672
申请日:1995-05-08
申请人: Yves Ducharme , Jacques Y. Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
发明人: Yves Ducharme , Jacques Y. Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
IPC分类号: C07D333/06 , A61K31/00 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/18 , A61K31/19 , A61K31/255 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/425 , A61K31/426 , A61K31/66 , A61P1/00 , A61P1/02 , A61P1/04 , A61P7/04 , A61P11/06 , A61P15/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/16 , A61P35/00 , A61P43/00 , C07C20060101 , C07C13/08 , C07C13/10 , C07C305/18 , C07C307/02 , C07C311/15 , C07C311/16 , C07C311/29 , C07C311/37 , C07C311/46 , C07C311/49 , C07C311/51 , C07C317/10 , C07C317/24 , C07C323/29 , C07D207/26 , C07D207/333 , C07D207/38 , C07D207/444 , C07D207/448 , C07D275/02 , C07D277/02 , C07D277/22 , C07D277/24 , C07D277/26 , C07D307/33 , C07D307/38 , C07D307/58 , C07D309/32 , C07D333/04 , C07D333/12 , C07D333/16 , C07D333/18 , C07D333/24 , C07D333/38 , C07D333/40 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D503/04 , C07F9/40 , C07F9/547 , C07F9/572 , C07F9/6506 , C07F9/653 , C07F9/6539 , C07F9/655
CPC分类号: C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04 , C07C2101/08
摘要: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译: 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。 本发明还包括用于治疗环氧合酶-2介导的疾病的某些药物组合物,其包含式I化合物。
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公开(公告)号:US5474995A
公开(公告)日:1995-12-12
申请号:US179467
申请日:1994-01-10
申请人: Yves Ducharme , Jacques Y. Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
发明人: Yves Ducharme , Jacques Y. Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
IPC分类号: C07D333/06 , A61K31/00 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/18 , A61K31/19 , A61K31/255 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/425 , A61K31/426 , A61K31/66 , A61P1/00 , A61P1/02 , A61P1/04 , A61P7/04 , A61P11/06 , A61P15/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/16 , A61P35/00 , A61P43/00 , C07C20060101 , C07C13/08 , C07C13/10 , C07C305/18 , C07C307/02 , C07C311/15 , C07C311/16 , C07C311/29 , C07C311/37 , C07C311/46 , C07C311/49 , C07C311/51 , C07C317/10 , C07C317/24 , C07C323/29 , C07D207/26 , C07D207/333 , C07D207/38 , C07D207/444 , C07D207/448 , C07D275/02 , C07D277/02 , C07D277/22 , C07D277/24 , C07D277/26 , C07D307/33 , C07D307/38 , C07D307/58 , C07D309/32 , C07D333/04 , C07D333/12 , C07D333/16 , C07D333/18 , C07D333/24 , C07D333/38 , C07D333/40 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D503/04 , C07F9/40 , C07F9/547 , C07F9/572 , C07F9/6506 , C07F9/653 , C07F9/6539 , C07F9/655 , A61K31/53 , C07D307/02
CPC分类号: C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04 , C07C2101/08
摘要: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases, ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译: 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。本发明还包括用于治疗包含式I化合物的环加氧酶-2介导的疾病的某些药物组合物。
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8.N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors 失效
标题翻译: N-苄基吲哚-3-基丁酸衍生物作为环加氧酶抑制剂公开(公告)号:US5639780A
公开(公告)日:1997-06-17
申请号:US445838
申请日:1995-05-22
申请人: Cheuk Kun Lau , Cameron Black , Daniel Guay , Jacques-Yves Gauthier , Yves LeBlanc , Patrick Roy , Yves Ducharme , Pierre Hamel
发明人: Cheuk Kun Lau , Cameron Black , Daniel Guay , Jacques-Yves Gauthier , Yves LeBlanc , Patrick Roy , Yves Ducharme , Pierre Hamel
IPC分类号: C07D209/22 , C07D233/54 , C07D401/12 , C07D403/06 , C07D413/06 , C07D417/06 , C07D521/00 , A61K31/405 , A61K31/395 , A61K31/44 , C07D209/04 , C07D209/18
CPC分类号: C07D231/12 , C07D209/22 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/06 , C07D413/06 , C07D417/06
摘要: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译: 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。 本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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9.N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors 失效
标题翻译: N-苄基吲哚-3-基丙酸衍生物作为环加氧酶抑制剂公开(公告)号:US5604253A
公开(公告)日:1997-02-18
申请号:US445624
申请日:1995-05-22
申请人: Cheuk K. Lau , Cameron Black , Daniel Guay , Jacques Y. Gauthier , Yves LeBlanc , Patrick Roy , Yves Ducharme , Pierre Hamel
发明人: Cheuk K. Lau , Cameron Black , Daniel Guay , Jacques Y. Gauthier , Yves LeBlanc , Patrick Roy , Yves Ducharme , Pierre Hamel
IPC分类号: C07D209/22 , C07D401/12 , C07D403/06 , C07D413/06 , A61K31/405 , C07D209/04 , C07D209/10
CPC分类号: C07D401/12 , C07D209/22 , C07D403/06 , C07D413/06
摘要: The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译: 本发明包括式I的新型化合物以及治疗环加氧酶-2介导的疾病的方法,其包括向需要这种治疗无效治疗有效量的式I化合物的患者给药。图像I 本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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10.
公开(公告)号:US20090286772A1
公开(公告)日:2009-11-19
申请号:US12224275
申请日:2007-02-22
申请人: Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Pierre Hamel
发明人: Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Pierre Hamel
IPC分类号: A61K31/4184 , C07D235/04 , C07D401/04 , C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/5377 , A61K31/541 , A61P25/00 , A61P19/00
CPC分类号: C07D235/02 , C07D401/04 , C07D403/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译: 本发明包括式(I)的新化合物或其药学上可接受的盐。 这些化合物是微粒体前列腺素E合酶-1(mPGES-1)酶的抑制剂,因此可用于治疗各种疾病或病症如骨关节炎,类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。 还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。
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