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公开(公告)号：US08546460B2
公开(公告)日：2013-10-01
申请号：US12673266
申请日：2008-09-04
申请人： Lorenz Brunner , Yvo Dirix , Hans Schmotzer , Shilesh C. Jani
发明人： Lorenz Brunner , Yvo Dirix , Hans Schmotzer , Shilesh C. Jani
CPC分类号： A61L27/26 , A61L27/50 , A61L27/54 , A61L2300/428
摘要： A prosthetic device may comprise an insert having a first surface configured to contact a first prosthetic component and a bearing surface configured to articulate against a second prosthetic component. The insert comprises an ultra-high molecular weight polyethylene and vitamin E. The vitamin E may have a concentration in the range of 0.02 to 0.12 wt % first mixed with the ultra-high molecular weight polyethylene and then molded with the ultra-high molecular weight polyethylene at a temperature greater than the melting point of the ultra-high molecular weight polyethylene. The ultra-high molecular weight polyethylene and vitamin E may be gamma irradiated with a dosage of radiation between 5 and 20 Mrad. The insert may be machined prior to gamma irradiating the insert in air such that the gamma irradiation, at suitably high dosages, may also sterilize the insert.
摘要翻译： 假体装置可以包括插入物，其具有构造成接触第一假体部件的第一表面和构造成与第二假体部件铰接的支承表面。 插入物包含超高分子量聚乙烯和维生素E.维生素E可以具有0.02至0.12重量％的浓度，首先与超高分子量聚乙烯混合，然后用超高分子量 聚乙烯，其温度大于超高分子量聚乙烯的熔点。 超高分子量聚乙烯和维生素E可以用5至20Mrad之间的辐射剂量照射γ射线。 在将伽马射线照射到空气中之前，可以对插入物进行加工，使得γ射线以合适的高剂量也可以对插入物进行消毒。
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公开(公告)号：US20110116968A1
公开(公告)日：2011-05-19
申请号：US12992595
申请日：2008-05-13
申请人： Lorenz Brunner , Yvo Dirix , Hans Schmotzer
发明人： Lorenz Brunner , Yvo Dirix , Hans Schmotzer
IPC分类号： A61L2/08
CPC分类号： C08K5/005 , C08J5/10 , C08L23/06 , C08L2666/02
摘要： The present invention relates to highly cross-linked UHMWPE, which is possessed of an improved oxidation resistance, as well as a method for making the same. The UHMWPE material of the current invention is combined with an anti-oxidant compound or a free-radical scavenger prior to formation. Once the UHMWPE with the added material has been formed and treated with gamma or electron bean irradiation, it shows an improved wear resistance and also a good resistance to oxidation. Such a material, is particularly interesting for the field of making replacement joint implants.
摘要翻译： 本发明涉及具有改善的抗氧化性的高度交联的UHMWPE及其制造方法。 本发明的UHMWPE材料在形成之前与抗氧化剂或自由基清除剂组合。 一旦用添加的材料形成UHMWPE并用γ射线或电子束照射进行处理，则其显示出改进的耐磨性和良好的耐氧化性。 这种材料对于替换关节植入物的领域尤其有意义。
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公开(公告)号：US20100144930A1
公开(公告)日：2010-06-10
申请号：US12531675
申请日：2007-03-20
申请人： Yvo Dirix , Hans Schmotzer , Lorenz Brunner
发明人： Yvo Dirix , Hans Schmotzer , Lorenz Brunner
CPC分类号： C08J7/123 , C08F8/00 , C08F2810/20 , C08J3/203 , C08J3/28 , C08J2323/06 , C08K5/005 , C08L23/06 , C08F110/02
摘要： The present invention relates to highly cross-linked UHMWPE, which is possessed of an improved oxidation resistance, as well as a method for making the same. The UHMWPE material of the current invention is combined with an anti-oxidant compound or a free-radical scavenger prior to formation. Once the UHMWPE with the added material has been formed and treated with gamma or electron beam irradiation, it shows an improved wear resistance and also a good resistance to oxidation. Such a material, is particularly interesting for the field of making replacement joint implants.
摘要翻译： 本发明涉及具有改善的抗氧化性的高度交联的UHMWPE及其制造方法。 本发明的UHMWPE材料在形成之前与抗氧化剂或自由基清除剂组合。 一旦已经用γ或电子束照射形成并处理了具有添加材料的UHMWPE，则其显示出改进的耐磨性和良好的耐氧化性。 这种材料对于替换关节植入物的领域尤其有意义。
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4.发明申请PROCESSES COMPRISING CROSSLINKING POLYETHYLENE OR USING CROSSLINKED POLYETHYLENE 有权包含交联聚乙烯或使用交联聚乙烯的方法公开(公告)号：US20100069576A1
公开(公告)日：2010-03-18
申请号：US12447866
申请日：2006-10-30
申请人： Hans Schmotzer , Yvo Dirix , Paul Smith , Theo Tervoort , Lorenz Brunner
发明人： Hans Schmotzer , Yvo Dirix , Paul Smith , Theo Tervoort , Lorenz Brunner
CPC分类号： B29C43/003 , B29C43/006 , B29K2023/0683 , B29L2031/7532
摘要： Provided are processes comprising crosslinking polyethylene or using crosslinked polyethylene. Furthermore, the processes may include compacting and/or sintering the polyethylene.
摘要翻译： 提供了包括交联聚乙烯或使用交联聚乙烯的方法。 此外，该方法可以包括压实和/或烧结聚乙烯。
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公开(公告)号：US08586667B2
公开(公告)日：2013-11-19
申请号：US12992595
申请日：2008-05-13
申请人： Lorenz Brunner , Yvo Dirix , Hans Schmotzer
发明人： Lorenz Brunner , Yvo Dirix , Hans Schmotzer
CPC分类号： C08K5/005 , C08J5/10 , C08L23/06 , C08L2666/02
摘要： The present invention relates to highly cross-linked UHMWPE, which is possessed of an improved oxidation resistance, as well as a method for making the same. The UHMWPE material of the current invention is combined with an anti-oxidant compound or a free-radical scavenger prior to formation. Once the UHMWPE with the added material has been formed and treated with gamma or electron bean irradiation, it shows an improved wear resistance and also a good resistance to oxidation. Such a material, is particularly interesting for the field of making replacement joint implants.
摘要翻译： 本发明涉及具有改善的抗氧化性的高度交联的UHMWPE及其制造方法。 本发明的UHMWPE材料在形成之前与抗氧化剂或自由基清除剂组合。 一旦用添加的材料形成UHMWPE并用γ射线或电子束照射进行处理，则其显示出改进的耐磨性和良好的耐氧化性。 这种材料对于替换关节植入物的领域尤其有意义。
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6.发明授权Processes comprising crosslinking polyethylene or using crosslinked polyethylene 有权包括交联聚乙烯或使用交联聚乙烯的方法公开(公告)号：US08871131B2
公开(公告)日：2014-10-28
申请号：US12447866
申请日：2006-10-30
申请人： Hans Schmotzer , Yvo Dirix , Paul Smith , Theo Tervoort , Lorenz Brunner
发明人： Hans Schmotzer , Yvo Dirix , Paul Smith , Theo Tervoort , Lorenz Brunner
IPC分类号： C08J5/00 , C08J5/16 , C08J3/28 , C08J3/24 , A61F2/30 , A61F2/02 , A61L27/16 , A61L27/14 , B29C43/00 , B29L31/00 , B29K23/00
CPC分类号： B29C43/003 , B29C43/006 , B29K2023/0683 , B29L2031/7532
摘要： Provided are processes comprising crosslinking polyethylene or using crosslinked polyethylene. Furthermore, the processes may include compacting and/or sintering the polyethylene. The polyethylene can comprise virgin ultrahigh molecular weight polyethylene having a weight average molecular weight of at least 1,000,000 g/mol, to provide a compacted composition comprising virgin ultrahigh molecular weight polyethylene.
摘要翻译： 提供了包括交联聚乙烯或使用交联聚乙烯的方法。 此外，该方法可以包括压实和/或烧结聚乙烯。 聚乙烯可以包含重均分子量至少为1,000,000g / mol的原始超高分子量聚乙烯，以提供包含原始超高分子量聚乙烯的压实组合物。
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公开(公告)号：US20110112646A1
公开(公告)日：2011-05-12
申请号：US12673266
申请日：2008-09-04
申请人： Lorenz Brunner , Yvo Dirix , Hans Schmotzer , Shilesh C. Jani
发明人： Lorenz Brunner , Yvo Dirix , Hans Schmotzer , Shilesh C. Jani
CPC分类号： A61L27/26 , A61L27/50 , A61L27/54 , A61L2300/428
摘要： A prosthetic device may comprise an insert having a first surface configured to contact a first prosthetic component and a bearing surface configured to articulate against a second prosthetic component. The insert comprises an ultra-high molecular weight polyethylene and vitamin E. The vitamin E may have a concentration in the range of 0.02 to 0.12 wt % first mixed with the ultra-high molecular weight polyethylene and then molded with the ultra-high molecular weight polyethylene at a temperature greater than the melting point of the ultra-high molecular weight polyethylene. The ultra-high molecular weight polyethylene and vitamin E may be gamma irradiated with a dosage of radiation between 5 and 20 Mrad. The insert may be machined prior to gamma irradiating the insert in air such that the gamma irradiation, at suitably high dosages, may also sterilize the insert.
摘要翻译： 假体装置可以包括插入物，其具有构造成接触第一假体部件的第一表面和构造成与第二假体部件铰接的支承表面。 插入物包含超高分子量聚乙烯和维生素E.维生素E可以具有0.02至0.12重量％的浓度，首先与超高分子量聚乙烯混合，然后用超高分子量 聚乙烯，其温度大于超高分子量聚乙烯的熔点。 超高分子量聚乙烯和维生素E可以用5至20Mrad之间的辐射剂量照射γ射线。 在将伽马射线照射到空气中之前，可以对插入物进行加工，使得γ射线以合适的高剂量也可以对插入物进行消毒。
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8.发明授权Open-pore biocompatible surface layer for an implant, methods of production and use 失效用于植入物的开孔生物相容性表面层，生产和使用方法公开(公告)号：US07998523B2
公开(公告)日：2011-08-16
申请号：US12092545
申请日：2006-10-12
申请人： Reto Lerf , Hans Schmotzer , Stephan Siegmann
发明人： Reto Lerf , Hans Schmotzer , Stephan Siegmann
IPC分类号： A61L33/00
CPC分类号： A61L27/56 , A61F2/30767 , A61F2002/3092 , A61F2002/30968 , A61L27/306 , Y10T428/12549
摘要： The invention relates to open-pore biocompatible surface layers for implants, which layers are arranged over virgin surfaces of the implants, wherein pores of the open-pore surface layers are connected to form coherent pore networks and the surface layers have a specific internal surface area of ≧0.06 μm/μm2, preferably ≧0.035 μm/μm2 and especially ≧0.025 μm/μm2, measured by image analysis as a 2D-boundary line per unit of surface area in a metallographic microsection at 100× magnification. The invention further relates to methods of producing such surface layers, to implants coated therewith and to possible uses of the surface layers.
摘要翻译： 本发明涉及用于植入物的开孔生物相容性表面层，其中层布置在植入物的原始表面上，其中开放孔表面层的孔连接以形成粘连孔网络，并且表面层具有特定的内表面积 通过在100倍放大倍率下的金相显微切片中的每单位表面积的2D边界线的图像分析测定的≥0.06μm/μm2，优选≥0.035μm/μm2，特别是≥0.025μm/μm2。 本发明还涉及生产这种表面层的方法，其中涂覆的植入物和表面层的可能用途。
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9.发明授权Method for producing implant parts from highly cross-linked UHMWPE and implant parts for human medicine 有权从高度交联的UHMWPE和人体植入物部位生产植入部件的方法公开(公告)号：US07364685B2
公开(公告)日：2008-04-29
申请号：US10468673
申请日：2002-01-31
申请人： Hans Schmotzer
发明人： Hans Schmotzer
CPC分类号： B29C35/08 , A61L27/16 , B29C35/0261 , B29C2035/0844 , B29C2035/085 , B29C2035/0855 , B29C2035/0877 , B29K2023/0683 , B29L2031/7532 , C08L23/06
摘要： The invention relates to a method of manufacturing implant parts made of highly cross-linked polyethylene, wherein a blank made of ultra-high-molecular-weight polyethylene is irradiated with ionizing radiation in order to produce radicals in the blank. To optimize the cross-linkage of the highly cross-linked polyethylene and to eliminate free radicals, the blank is subsequently treated by means of microwave radiation and/or ultrasound in such a way that free radicals, which have not recombined, are excited so as to ensure substantially complete recombination of the free radicals. The shape of the treated blank can then be adjusted by means of machining. The invention further relates to implant parts for application in human medicine that have been manufactured as described above.
摘要翻译： 本发明涉及一种制造由高度交联的聚乙烯制成的植入部件的方法，其中由超高分子量聚乙烯制成的坯料用电离辐射照射以在坯料中产生自由基。 为了优化高度交联的聚乙烯的交联并消除自由基，随后通过微波辐射和/或超声波处理空白物，使得未再结合的自由基被激发，使得 以确保自由基的基本上完全的复合。 然后可以通过机械加工处理的坯料的形状。 本发明还涉及如上所述制造的用于人类医学中的植入部件。
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公开(公告)号：US20100042223A9
公开(公告)日：2010-02-18
申请号：US11722697
申请日：2005-12-22
申请人： Olivier Zinger , Hans Schmotzer
发明人： Olivier Zinger , Hans Schmotzer
CPC分类号： A61F2/30767 , A61C8/0012 , A61C2008/0046 , A61F2/3094 , A61F2/32 , A61F2002/30719 , A61F2002/30906 , A61F2002/30925 , A61F2250/0092 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/00095 , A61F2310/00131 , A61L27/30 , A61L27/50 , A61L2400/18 , A61L2430/02 , B24C1/06 , C23G1/086 , C23G1/106
摘要： A method of surface finishing a bone implant comprises the steps of roughening a surface of the implant by blasting with abrasive particles and then pickling the surface-roughened implant in a pickling solution in order to loosen any partially embedded abrasive blasting particles that may be contaminating the surface of the implant. Thereafter the roughened surface of the implant is cleaned by mechanical action to detach the loosened abrasive particles there from. The pickling and cleaning steps are not intended to produce any additional roughening of the treated surface, which should be structured to the required roughness by the initial abrasive blasting, typically such that the Ra and Rt roughness parameters are 3≦Ra≦7 μm and 20≦Rt≦70 μm respectively.
摘要翻译： 骨植入物表面处理的方法包括以下步骤：通过用研磨颗粒喷砂来粗糙化植入物的表面，然后在酸洗溶液中酸化表面粗糙植入物，以便松动任何可能污染的植入物的部分包埋的喷砂颗粒 植入物的表面。 此后，通过机械作用来清洁植入物的粗糙表面，以将松散的磨料颗粒从其上分离。 酸洗和清洁步骤不是为了产生经处理的表面的任何额外的粗糙化，其应该通过初始的喷砂处理构造成所需的粗糙度，通常使得Ra和Rt粗糙度参数为3＆lt; Ra＆nlE;7μm和20＆amp; ; Rt＆nlE;70μm。
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