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公开(公告)号:US09850543B2
公开(公告)日:2017-12-26
申请号:US14777211
申请日:2014-03-12
IPC分类号: A61K31/70 , C07H21/02 , C07H21/04 , C12Q1/68 , C12N15/113 , G01N33/574 , C12N5/00
CPC分类号: C12Q1/6886 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/57496 , G01N2333/914
摘要: The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided.
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公开(公告)号:US20150322528A1
公开(公告)日:2015-11-12
申请号:US14408893
申请日:2013-06-26
申请人: Giordano Caponigro , Scott Delach , Levi Garraway , Zainab Jagani , Sunkyu Kim , Gregory Kryukov
发明人: Giordano Caponigro , Scott Delach , Levi Garraway , Zainab Jagani , Sunkyu Kim , Gregory Kryukov
IPC分类号: C12Q1/68 , A61K31/506 , A61K31/519 , A61K31/454 , G01N33/574 , G01N33/50
CPC分类号: C12Q1/6886 , A61K31/454 , A61K31/506 , A61K31/519 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/5011 , G01N33/57496 , G01N2333/4739 , G01N2440/14 , G01N2500/04 , G01N2500/10
摘要: The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Cyclin Dependent kinase inhibitors (CDKi), methods of determining the sensitivity of a cell to a CDKi, methods of treating a patient with a CDKi and methods of screening for candidate CDKi.
摘要翻译: 本发明提供了监测生物标志物的差异基因表达以确定患者对细胞周期蛋白依赖性激酶抑制剂(CDKi)的敏感性的方法,确定细胞对CDKi的敏感性的方法,用CDKi治疗患者的方法和筛选候选者的方法 CDKi。
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