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1.发明授权2.alpha.-(2-Loweralkanoyloxy-2-carboxyvinyl)-3.beta.-hydroxy-5-oxo-1.beta.- c 失效2 {60-（2-低级烷酰氧基-2-羧基乙烯基）-3 {62-羟基-5-氧代-1 {62-环戊烷庚酸和方法
公开(公告)号：US3991083A
公开(公告)日：1976-11-09
申请号：US575884
申请日：1975-05-08
IPC分类号： C07C405/00 , C07D317/72
CPC分类号： C07C405/00
摘要： Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha.,6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, 5-cyclic ethylene acetal.
摘要翻译： 外消旋或光学活性的前列腺素E1是从3α，6,7,7α-四氢-4-甲基-2-氧代-1'-茚满庚酸甲酯的各个步骤以良好的产率从外消旋或光学活性前体合成的 酯通过2α-（2-羧乙基）-3β-羟基-5-氧代-1,2-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛，2α-（2-羧基-2-甲基乙基 ）-3β-羟基-5-氧代-1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛，2α-（2-羧基-2-氧代乙基）-3β-羟基-5-氧代 -1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛和3β-羟基-2α-（3-氧代-1-辛烯基）-5-氧代-1β-环戊烷庚酸甲酯， 5-环乙缩醛。
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2.发明授权3.beta.-[(Methoxalyl)oxy]-2.alpha.-(3-oxo-1-octeny l)-5-oxo-1.beta.-cyclopentaneheptanoic acid and process 失效3 {62 - {8（甲氧基）氧基{9-2 {60-（3-氧代-1-辛烯基）-5-氧代-1 {62-环戊烷庚酸和方法
公开(公告)号：US4005106A
公开(公告)日：1977-01-25
申请号：US575278
申请日：1975-05-07
IPC分类号： C07C405/00 , C07D317/08
CPC分类号： C07C405/00
摘要： Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha.,6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoetyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, 5-cyclic ethylene acetal.
摘要翻译： 外消旋或光学活性的前列腺素E1是从3α，6,7,7α-四氢-4-甲基-2-氧代-1'-茚满庚酸甲酯的各个步骤以良好的产率从外消旋或光学活性前体合成的 酯通过2α-（2-羧乙基）-3β-羟基-5-氧代-1,2-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛，2α-（2-羧基-2-甲基乙基 ）-3β-羟基-5-氧代-1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛，2α-（2-羧基-2-氧代乙酰基）-3β-羟基-5-氧代 -1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛和3β-羟基-2α-（3-氧代-1-辛烯基）-5-氧代-1β-环戊烷庚酸甲酯， 5-环乙缩醛。
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3.发明授权2.alpha.-(2-Carboxy-2-formylethyl )-3.beta.-hydroxy-5-oxo-.beta.-cyclopentaneheptanoic acid and process 失效2' - （2-羧氧基-2-甲基）-3' - 羟基-5-氧代 - 环己烷氨基酸和方法
公开(公告)号：US3998849A
公开(公告)日：1976-12-21
申请号：US575676
申请日：1975-05-08
IPC分类号： C07C405/00 , C07D317/72
CPC分类号： C07C405/00
摘要： Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha.,6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, 5-cyclic ethylene acetal.
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4.发明授权2.alpha.-(2-Carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-c yclopentaneheptanoic acid and process 失效2 {60-（2-羧基-2-氧代乙基）-3 {62-羟基-5-氧代-1 {62-环戊烷庚酸和方法
公开(公告)号：US3992412A
公开(公告)日：1976-11-16
申请号：US575904
申请日：1975-05-08
IPC分类号： C07C405/00 , C07D317/72
CPC分类号： C07C405/00
摘要： Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha., 6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, 5-cyclic ethylene acetal.
摘要翻译： 外消旋或光学活性的前列腺素E1是从3α，6,7,7α-四氢-4-甲基-2-氧代-1'-茚满庚酸甲酯的各个步骤以良好的产率从外消旋或光学活性前体合成的 酯通过2α-（2-羧乙基）-3β-羟基-5-氧代-1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛，2α-（2-羧基-2-甲基乙基 ）-3β-羟基-5-氧代-1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛，2α-（2-羧基-2-氧代乙基）-3β-羟基-5-氧代 -1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛和3β-羟基-2α-（3-氧代-1-辛烯基）-5-氧代-1β-环戊烷庚酸甲酯， 5-环乙缩醛。
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5.发明授权2.alpha.-Formyl-3.beta.-[(methoxalyl)oxy]-5-oxo-1.beta.-cyclopentanehepta noic acid and process 失效2 {60-甲酰基-3 {62- {8（甲氧基）氧基{9-5-氧代-1 {62-环戊烷庚酸和方法
公开(公告)号：US3992411A
公开(公告)日：1976-11-16
申请号：US575762
申请日：1975-05-08
IPC分类号： C07C405/00 , C07D317/72
CPC分类号： C07C405/00
摘要： Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha., 6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentaneheptanoic acid methyl ester, 5-cyclic ethylene acetal.
摘要翻译： 外消旋或光学活性的前列腺素E1是从3α，6,7,7α-四氢-4-甲基-2-氧代-1'-茚满庚酸甲酯的各个步骤以良好的产率从外消旋或光学活性前体合成的 酯通过2α-（2-羧乙基）-3β-羟基-5-氧代-1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛，2α-（2-羧基-2-甲基乙基 ）-3β-羟基-5-氧代-1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛，2α-（2-羧基-2-氧代乙基）-3β-羟基-5-氧代 -1β-环戊烷庚酸甲酯，δ-内酯，5-环乙缩醛和3β-羟基-2α-（3-氧代-1-辛烯基）-5-氧代-1β-环戊烷庚酸甲酯， 5-环乙缩醛。
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公开(公告)号：US3978115A
公开(公告)日：1976-08-31
申请号：US577267
申请日：1975-05-14
摘要： The disclosure relates to novel precursors for the synthesis of prostaglandin E.sub.1 and the production of said precursors.
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公开(公告)号：US3933901A
公开(公告)日：1976-01-20
申请号：US356528
申请日：1973-05-02
IPC分类号： C07C69/03 , C07C43/16 , C07C43/18 , C07C61/00 , C07C67/00 , C07C69/00 , C07C69/02 , C07C69/08 , C07C69/16 , C07C69/28 , C07C69/76 , C07C401/00 , C07C405/00 , C07D307/89
摘要： This case relates to the synthesis of novel precursors of prostaglandin E.sub.1, particularly the intermediate 4-hydroxy-3 .alpha.-methyl-1.alpha., 2.alpha.-dilower-alkanoyloxymethylcyclohexene.
摘要翻译： 这一情况涉及前列腺素E1的新型前体的合成，特别是中间体4-羟基-3α-甲基-1α，2α-二低级烷酰氧基甲基环己烯的合成。
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