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1.Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus 失效
标题翻译: 二芳基肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂公开(公告)号:US06911428B2
公开(公告)日:2005-06-28
申请号:US10013071
申请日:2001-12-10
申请人: Zhaoning Zhu , Zhong-Yue Sun , Srikanth Venkatraman , F. George Njoroge , Ashok Arasappan , Bruce A. Malcolm , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Kevin X. Chen
发明人: Zhaoning Zhu , Zhong-Yue Sun , Srikanth Venkatraman , F. George Njoroge , Ashok Arasappan , Bruce A. Malcolm , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Kevin X. Chen
IPC分类号: C12N9/99 , A61K31/7042 , A61K38/00 , A61K38/21 , A61K45/00 , A61P31/12 , A61P31/14 , A61P43/00 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/00 , C07K14/81 , A61K38/17 , A61K31/33 , C07K7/64
CPC分类号: C07K5/0202 , A61K38/00 , C07K14/811
摘要: The present invention is directed to certain diaryl amide compounds as NS3-Serine protease inhibitors of hepatitis C virus. A particularly preferred compound is of the formula:
摘要翻译: 本发明涉及某些二芳基酰胺化合物作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂。 特别优选的化合物具有下式:
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2.
公开(公告)号:US07595299B2
公开(公告)日:2009-09-29
申请号:US11089192
申请日:2005-03-24
申请人: Anil Saksena , Viyyoor M. Girijavallabhan , Stephane L. Bogen , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin X. Chen , Srikanth Venkatraman , Tejal Parekh , Patrick A. Pinto , Bama Santhanam , F. George Njoroge , Ashit K. Ganguly , Henry A. Vaccaro , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura
发明人: Anil Saksena , Viyyoor M. Girijavallabhan , Stephane L. Bogen , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin X. Chen , Srikanth Venkatraman , Tejal Parekh , Patrick A. Pinto , Bama Santhanam , F. George Njoroge , Ashit K. Ganguly , Henry A. Vaccaro , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura
IPC分类号: A61K38/00
CPC分类号: C07K7/06 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K38/05 , C07C205/51 , C07K5/101 , C07K7/02 , A61K2300/00
摘要: The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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3.Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease 有权
标题翻译: 硫化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号:US08067379B2
公开(公告)日:2011-11-29
申请号:US11064673
申请日:2005-02-24
申请人: Frank Bennett , Raymond G. Lovey , Yuhua Huang , Siska Hendrata , Anil K. Saksena , Stephane L. Bogen , Yi-Tsung Liu , F. George Njoroge , Srikanth Venkatraman , Kevin X. Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor M. Girijavallabhan , Francisco Velazquez , Latha G. Nair
发明人: Frank Bennett , Raymond G. Lovey , Yuhua Huang , Siska Hendrata , Anil K. Saksena , Stephane L. Bogen , Yi-Tsung Liu , F. George Njoroge , Srikanth Venkatraman , Kevin X. Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor M. Girijavallabhan , Francisco Velazquez , Latha G. Nair
IPC分类号: A61K38/06
CPC分类号: C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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4.
公开(公告)号:US06894072B2
公开(公告)日:2005-05-17
申请号:US10348094
申请日:2003-01-21
申请人: Ashok Arasappan , Frank Bennett , Stephane L. Bogen , Kevin X. Chen , Edwin Jao , Yi-Tsung Liu , Raymond G. Lovey , Vincent S. Madison , Latha G. Nair , F. George Njoroge , Anil K. Saksena , Mousumi Sannigrahi , Srikanth Venkatraman , Viyyoor M. Girijavallabhan
发明人: Ashok Arasappan , Frank Bennett , Stephane L. Bogen , Kevin X. Chen , Edwin Jao , Yi-Tsung Liu , Raymond G. Lovey , Vincent S. Madison , Latha G. Nair , F. George Njoroge , Anil K. Saksena , Mousumi Sannigrahi , Srikanth Venkatraman , Viyyoor M. Girijavallabhan
IPC分类号: A61K31/403 , A61K31/7052 , A61K38/21 , A61P1/16 , A61P31/12 , A61P31/14 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/75 , C07D217/26 , C07D233/68 , C07D243/12 , C07D253/06 , C07D271/06 , C07D277/06 , C07D277/46 , C07D277/56 , C07D295/15 , C07D307/68 , C07D317/58 , C07D335/10 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D209/02
CPC分类号: C07D207/27 , C07D207/16 , C07D209/08 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/75 , C07D217/26 , C07D233/68 , C07D243/12 , C07D253/06 , C07D271/06 , C07D277/06 , C07D277/46 , C07D277/56 , C07D295/15 , C07D307/68 , C07D317/58 , C07D335/10 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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5.
公开(公告)号:US07244721B2
公开(公告)日:2007-07-17
申请号:US10052386
申请日:2002-01-18
申请人: Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse K. Wong , Latha G. Nair
发明人: Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse K. Wong , Latha G. Nair
IPC分类号: A61K31/497 , A61K31/407 , A61K31/454 , A61K31/4025
CPC分类号: C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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6.
公开(公告)号:USRE43298E1
公开(公告)日:2012-04-03
申请号:US13068159
申请日:2011-04-22
申请人: Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry M. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人: Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry M. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
IPC分类号: A61K38/00 , A01N37/18 , A61P1/16 , A61P31/12 , A61K39/12 , G01N33/53 , A61K38/07 , A61K38/06 , C07K5/08 , C07K5/10
CPC分类号: C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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7.NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS 审中-公开
标题翻译: 新型肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂公开(公告)号:US20110117057A1
公开(公告)日:2011-05-19
申请号:US12973020
申请日:2010-12-20
申请人: Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人: Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
IPC分类号: A61K38/06 , C07D207/16 , C07D403/10 , C07K5/083 , C07D209/42 , C07K5/107 , C07D215/48 , A61K38/05 , A61K38/07 , A61K38/21 , A61P31/14
CPC分类号: C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号:US07012066B2
公开(公告)日:2006-03-14
申请号:US09908955
申请日:2001-07-19
申请人: Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人: Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
CPC分类号: C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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9.Ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus 失效
标题翻译: 具有环状P4的酮酰胺作为丙型肝炎病毒的NS3丝氨酸蛋白酶的抑制剂公开(公告)号:US07619094B2
公开(公告)日:2009-11-17
申请号:US11602174
申请日:2006-11-20
申请人: Kevin X Chen , F George Njoroge , Mousumi Sannigrahi , Latha G Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
发明人: Kevin X Chen , F George Njoroge , Mousumi Sannigrahi , Latha G Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
IPC分类号: C07D209/02 , C07D403/12 , A61K31/403
CPC分类号: C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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10.Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus 有权
标题翻译: 具有环状P4'S的酮酰胺作为丙型肝炎病毒NS3蛋白酶的抑制剂公开(公告)号:US07173057B2
公开(公告)日:2007-02-06
申请号:US11065647
申请日:2005-02-24
申请人: Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
发明人: Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
IPC分类号: A61K31/4035 , A61K31/403 , A61K31/407 , A61K31/454 , A61K31/5355 , A61K31/4725 , A61K31/4166 , C07D209/48 , C07D209/52 , C07D209/02 , C07D471/02 , C07D401/12 , C07D413/12 , C07D217/24 , C07D233/02 , C07D233/74
CPC分类号: C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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