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公开(公告)号：US20100075965A1
公开(公告)日：2010-03-25
申请号：US12279148
申请日：2007-02-14
申请人： Zhi-Jie Ni , Sabina Pecchi , Matthew Burger , Wooseok Han , Aaron Smith , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Joelle Verhagen , Yanchen Zhang , Ed Iwanowicz , Tom Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Darren Mark Legrand , Ian Bruce , James Dale , Jiong Lan , Barry Levine , Abran Costales , Jui Liu , Teresa Pick , Daniel Menezes
发明人： Zhi-Jie Ni , Sabina Pecchi , Matthew Burger , Wooseok Han , Aaron Smith , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Joelle Verhagen , Yanchen Zhang , Ed Iwanowicz , Tom Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Darren Mark Legrand , Ian Bruce , James Dale , Jiong Lan , Barry Levine , Abran Costales , Jui Liu , Teresa Pick , Daniel Menezes
IPC分类号： A61K31/5377 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/437 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.
摘要翻译： 磷脂酰肌醇（PI）3激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂联合使用的新化合物在预防或治疗以生长因子，蛋白丝氨酸/苏氨酸激酶，磷脂激酶，G蛋白偶联的异常活性为特征的增殖性疾病中的用途 受体和磷酸酶。
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公开(公告)号：US08217035B2
公开(公告)日：2012-07-10
申请号：US12161537
申请日：2007-01-22
申请人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Xiaohua Xin
发明人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Xiaohua Xin
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。
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公开(公告)号：US20100249126A1
公开(公告)日：2010-09-30
申请号：US12161537
申请日：2007-01-22
申请人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
发明人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
IPC分类号： A61K31/5377 , C07D413/14 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。
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公开(公告)号：US08563549B2
公开(公告)日：2013-10-22
申请号：US13471111
申请日：2012-05-14
申请人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Ataliah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
发明人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Ataliah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。
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公开(公告)号：US08173647B2
公开(公告)日：2012-05-08
申请号：US12449286
申请日：2008-02-06
申请人： Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
发明人： Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.
摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗特征在于生长因子异常活性，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶（包括增殖性疾病）的疾病中的用途， 炎性和阻塞性气道疾病，过敏性疾病，自身免疫性疾病和心血管疾病。
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公开(公告)号：US20100048547A1
公开(公告)日：2010-02-25
申请号：US12449286
申请日：2008-02-06
申请人： Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
发明人： Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/538 , A61P29/00 , A61P35/00 , A61P11/00 , A61P37/08 , A61P37/00 , A61P9/00
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.
摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗特征在于生长因子异常活性，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶（包括增殖性疾病）的疾病中的用途， 炎性和阻塞性气道疾病，过敏性疾病，自身免疫性疾病和心血管疾病。
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公开(公告)号：USD794479S1
公开(公告)日：2017-08-15
申请号：US29556750
申请日：2016-03-03
申请人： Yanchen Zhang , Meng Zhang
设计人： Yanchen Zhang , Meng Zhang
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公开(公告)号：US08925210B2
公开(公告)日：2015-01-06
申请号：US13736949
申请日：2013-01-09
申请人： Yanchen Zhang , Meng Zhang
发明人： Yanchen Zhang , Meng Zhang
摘要： The current marking gauges, mortise gauges and circle marking gauges on the market require use of a ruler to measure distances prior to marking, which is inconvenient and time consuming. Moreover, the accuracy of the marked dimension is inexact due to the low accuracy of using a ruler. Furthermore, parallax error created by transferring the measured distance between the rule and the gauges also needs to be accounted for, which reduces accuracy even further. This present invention helps to improve the accuracy of the measurement and marking of the gauges, increases efficiency, convenience, saves time and is easy to use. The new product is a digital multifunctional marking gauge, that includes a Digital Unit, Main Slider, Beam, Display, Fixed Pin, Adjustable Pin, Adjustment Slider, Fence, Calibration Frame, Calibration bar, Setting Block, Scriber, Set function button of the Digital Unit, Locking Screw, Fixing Screws and related components.
摘要翻译： 目前市面上的标记量规，榫眼和圆圈标记仪要求使用尺子来测量标记之前的距离，这是不方便和耗时的。 此外，标尺尺寸的精度由于使用标尺的准确度低而不准确。 此外，还需要考虑通过传递规则和量规之间的测量距离而产生的视差误差，这进一步降低了精度。 本发明有助于提高量规的测量和标记的精度，提高效率，方便，节省时间，易于使用。 新产品是数字多功能标记仪，包括数字单元，主滑块，光束，显示器，固定针，可调节针，调整滑块，围栏，校准框，校准杆，设置块，划线器，设置功能按钮 数字单元，锁定螺丝，固定螺丝及相关部件。
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公开(公告)号：US20140190024A1
公开(公告)日：2014-07-10
申请号：US13736949
申请日：2013-01-09
申请人： Yanchen Zhang , Meng Zhang
发明人： Yanchen Zhang , Meng Zhang
IPC分类号： G01B3/00
摘要： The current marking gauges, mortise gauges and circle marking gauges on the market require use of a ruler to measure distances prior to marking, which is inconvenient and time consuming. Moreover, the accuracy of the marked dimension is inexact due to the low accuracy of using a ruler. Furthermore, parallax error created by transferring the measured distance between the rule and the gauges also needs to be accounted for, which reduces accuracy even further. This present invention helps to improve the accuracy of the measurement and marking of the gauges, increases efficiency, convenience, saves time and is easy to use. The new product is a digital multifunctional marking gauge, that includes a Digital Unit, Main Slider, Beam, Display, Fixed Pin, Adjustable Pin, Adjustment Slider, Fence, Calibration Frame, Calibration bar, Setting Block, Scriber, Set function button of the Digital Unit, Locking Screw, Fixing Screws and related components.
摘要翻译： 目前市面上的标记量规，榫眼和圆圈标记仪要求使用尺子来测量标记之前的距离，这是不方便和耗时的。 此外，标尺尺寸的精度由于使用标尺的准确度低而不准确。 此外，还需要考虑通过传递规则和量规之间的测量距离而产生的视差误差，这进一步降低了精度。 本发明有助于提高量规的测量和标记的精度，提高效率，方便，节省时间，易于使用。 新产品是数字多功能标记仪，包括数字单元，主滑块，光束，显示器，固定针，可调节针，调整滑块，围栏，校准框，校准杆，设置块，划线器，设置功能按钮 数字单元，锁定螺丝，固定螺丝及相关部件。
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公开(公告)号：US20100256092A1
公开(公告)日：2010-10-07
申请号：US12464829
申请日：2009-05-12
申请人： Yi Xia , Michael Richard Kevin Alley , Yasheen Zhou , Vincent S. Hernandez , Jacob J. Plattner , Charles Z. Ding , Kathy Cao , Yong-Kang Zhang , Andrew Benowitz , Tsutomu Akama , Jessica Sligar , Guofeng Jia , Ligong Ou , Neerja Saraswat , Sreekanth Ramachandran , Chris Diaper , Yanchen Zhang , Goverdhan Reddy Banda , James A. Nieman , Mehdi Keramane , Rahim Mohammed , Rajendra Subedi , Hong Liang , Rajeshwar Singh
发明人： Yi Xia , Michael Richard Kevin Alley , Yasheen Zhou , Vincent S. Hernandez , Jacob J. Plattner , Charles Z. Ding , Kathy Cao , Yong-Kang Zhang , Andrew Benowitz , Tsutomu Akama , Jessica Sligar , Guofeng Jia , Ligong Ou , Neerja Saraswat , Sreekanth Ramachandran , Chris Diaper , Yanchen Zhang , Goverdhan Reddy Banda , James A. Nieman , Mehdi Keramane , Rahim Mohammed , Rajendra Subedi , Hong Liang , Rajeshwar Singh
CPC分类号： A61K31/33 , A61K31/43 , A61K45/06 , C07F5/025 , Y02A50/401 , Y02A50/411 , A61K2300/00
摘要： This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译： 本发明涉及6-取代的苯并恶唑化合物及其用于治疗细菌感染的用途。
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