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公开(公告)号：US07329764B2
公开(公告)日：2008-02-12
申请号：US10902562
申请日：2004-07-29
申请人： Zhidong Chen , John David Ginn , Eugene Richard Hickey , Weimin Liu , Can Mao , Tina Marie Morwick , Peter Allen Nemoto , Denice Spero , Sanxing Sun
发明人： Zhidong Chen , John David Ginn , Eugene Richard Hickey , Weimin Liu , Can Mao , Tina Marie Morwick , Peter Allen Nemoto , Denice Spero , Sanxing Sun
IPC分类号： C07D333/00 , A61K31/38
CPC分类号： C07D409/04 , A61K31/38 , C07D333/70 , C07D409/14
摘要： Disclosed are compounds of the formula I shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds
摘要翻译： 公开了下文所示的式I化合物，其中R1，R2，R3和R4如本文所述，其作为抗炎剂是有活性的。 还公开了使用和制备这些化合物的方法
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公开(公告)号：US08580829B2
公开(公告)日：2013-11-12
申请号：US13215654
申请日：2011-08-23
申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号： C07D413/14 , A61K31/4245 , C07D413/10 , C07D417/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US08420655B2
公开(公告)日：2013-04-16
申请号：US12957766
申请日：2010-12-01
申请人： Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu
发明人： Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu
IPC分类号： A61K31/506 , C07D403/14
CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 7如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US06878706B1
公开(公告)日：2005-04-12
申请号：US10400385
申请日：2003-03-27
IPC分类号： C07C261/04 , C07D217/06 , C07D295/185 , A61K31/535 , A01N43/12 , A01N43/70 , A61K31/44 , A61K31/4965
CPC分类号： C07D295/185 , C07C261/04 , C07D217/06
摘要： Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B; pharmaceutical compositions containing such compounds, and method of treating diseases and pathological conditions exacerbated by these cysteine proteases such as, but not limited to rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, osteoporosis, asthma, Alzheimer's disease, atherosclerosis and endometriosis.
摘要翻译： 根据下式（I）的化合物：其中变量Q和R 1至R 6如本文所述，其可逆地抑制半胱氨酸蛋白酶，例如组织蛋白酶K，S，F，L和B; 含有这些化合物的药物组合物，以及治疗由这些半胱氨酸蛋白酶（例如但不限于类风湿性关节炎，多发性硬化症和其他自身免疫疾病，骨质疏松症，哮喘，阿尔茨海默氏病，动脉粥样硬化和子宫内膜异位症）加重的疾病和病理状况的方法。
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公开(公告)号：US09150556B2
公开(公告)日：2015-10-06
申请号：US12596152
申请日：2008-05-15
申请人： Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
发明人： Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
IPC分类号： C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
CPC分类号： C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要： Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
摘要翻译： 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。
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公开(公告)号：US20100240702A1
公开(公告)日：2010-09-23
申请号：US12596152
申请日：2008-05-15
申请人： Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
发明人： Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
IPC分类号： A61K31/454 , C07D235/26 , C07D211/32 , A61K31/4166 , A61P9/12 , A61P9/10 , A61P13/12
CPC分类号： C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要： Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
摘要翻译： 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。
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公开(公告)号：US09181272B2
公开(公告)日：2015-11-10
申请号：US14262828
申请日：2014-04-28
申请人： Michael Balestra , Jennifer Burke , Zhidong Chen , Derek Cogan , Lee Fader , Xin Guo , Bryan McKibben , Daniel Richard Marshall , Peter Allen Nemoto , Hui Yu
发明人： Michael Balestra , Jennifer Burke , Zhidong Chen , Derek Cogan , Lee Fader , Xin Guo , Bryan McKibben , Daniel Richard Marshall , Peter Allen Nemoto , Hui Yu
IPC分类号： C07D471/02 , C07D498/04 , C07D471/04
CPC分类号： C07D498/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，W，Y，m和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08772304B2
公开(公告)日：2014-07-08
申请号：US13281687
申请日：2011-10-26
IPC分类号： C07D401/14 , A61K31/4184
CPC分类号： C07D401/14
摘要： The present invention relates to compounds of formula (IA), (IB) and (IC): and pharmaceutically acceptable salts thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（IA），（IB）和（IC）的化合物及其药学上可接受的盐，其中R 1 -R 7如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US09062056B2
公开(公告)日：2015-06-23
申请号：US13062749
申请日：2009-08-25
申请人： Michel Jose Emmanuel , Xin Guo , Jin Mi Kim , Ho Yin Lo , Peter Allen Nemoto , Kevin Chungeng Qian
发明人： Michel Jose Emmanuel , Xin Guo , Jin Mi Kim , Ho Yin Lo , Peter Allen Nemoto , Kevin Chungeng Qian
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Disclosed are small molecule inhibitors of the formula (I): and the pharmaceutical compositions thereof and processes of making the same. The compounds are useful in treating various diseases and conditions involving chymase.
摘要翻译： 公开了式（I）的小分子抑制剂及其药物组合物及其制备方法。 该化合物可用于治疗涉及胃促胰酶的各种疾病和病症。
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公开(公告)号：US07138420B2
公开(公告)日：2006-11-21
申请号：US10632888
申请日：2003-08-01
申请人： Joerg Martin Bentzien , Brian Nicholas Cook , Charles Cywin , Roman Wolfgang Fleck , Ho Yin Lo , Peter Allen Nemoto , Steven S. Pullen , Gregory Paul Roth , Roger John Snow , Hidenori Takahashi , Ji Wang , Kevin J. Moriarty , Lei Qiao , Michael Winters
发明人： Joerg Martin Bentzien , Brian Nicholas Cook , Charles Cywin , Roman Wolfgang Fleck , Ho Yin Lo , Peter Allen Nemoto , Steven S. Pullen , Gregory Paul Roth , Roger John Snow , Hidenori Takahashi , Ji Wang , Kevin J. Moriarty , Lei Qiao , Michael Winters
IPC分类号： A61K31/4184 , C07D235/30
CPC分类号： C07D409/12 , C07D235/30
摘要： Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的取代的苯并咪唑化合物：其中R 1，R 2，R 3，R 4， >和X > 。 本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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