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    Method of storing an electrotransport drug delivery device
    1.
    发明授权
    Method of storing an electrotransport drug delivery device 有权
    储存电转运药物输送装置的方法

    公开(公告)号：US09364656B2

    公开(公告)日：2016-06-14

    申请号：US14002909

    申请日：2012-03-09

    申请人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    发明人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    IPC分类号： A61H1/00 ,  A61N1/04 ,  A61N1/32

    CPC分类号： A61N1/08 ,  A61N1/0412 ,  A61N1/0448 ,  A61N1/325 ,  Y10T29/49117

    摘要： A switch operated therapeutic agent delivery device is described. The device comprises two parts, which are assembled by a user prior to use. A first part contains a power supply and circuitry for the device; and a second part comprises electrodes and reservoirs containing the therapeutic agent to be delivered. The action of combining the two parts of the device causes the two parts to be irreversibly coupled together, completes an electrical connection between the two parts, and closes one or more switches, thereby connecting a power source, such as a battery, into the device's circuitry, thereby powering the device on so that it is ready for use. The device can then be attached to a patient, who can operate the device by pressing a button in a proper sequence.

    摘要翻译： 描述了开关操作的治疗剂递送装置。 该装置包括两个部件，它们在使用之前由使用者组装。 第一部分包含设备的电源和电路; 并且第二部分包括含有要递送的治疗剂的电极和储存器。 组合装置的两个部分的动作导致两个部分不可逆地耦合在一起，完成两部分之间的电连接，并闭合一个或多个开关，从而将诸如电池的电源连接到装置的 电路，从而为设备供电以使其准备使用。 然后，该装置可以附接到患者，他们可以通过按正确的顺序按下按钮来操作该装置。

    Two-part electrotransport device
    2.
    发明授权
    Two-part electrotransport device 有权
    两部分电转运装置

    公开(公告)号：US08301238B2

    公开(公告)日：2012-10-30

    申请号：US13250031

    申请日：2011-09-30

    申请人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    发明人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    IPC分类号： A61N1/30

    CPC分类号： A61N1/08 ,  A61N1/0412 ,  A61N1/0448 ,  A61N1/325 ,  Y10T29/49117

    摘要： A switch operated therapeutic agent delivery device is described. The device comprises two parts, which are assembled by a user prior to use. A first part contains a power supply and circuitry for the device; and a second part comprises electrodes and reservoirs containing the therapeutic agent to be delivered. The action of combining the two parts of the device causes the two parts to be irreversibly coupled together, completes an electrical connection between the two parts, and closes one or more switches, thereby connecting a power source, such as a battery, into the device's circuitry, thereby powering the device on so that it is ready for use. The device can then be attached to a patient, who can operate the device by pressing a button in a proper sequence.

    摘要翻译： 描述了开关操作的治疗剂递送装置。 该装置包括两个部件，它们在使用之前由使用者组装。 第一部分包含设备的电源和电路; 并且第二部分包括含有要递送的治疗剂的电极和储存器。 组合装置的两个部分的动作导致两个部分不可逆地耦合在一起，完成两部分之间的电连接，并闭合一个或多个开关，从而将诸如电池的电源连接到装置的 电路，从而为设备供电以使其准备使用。 然后，该装置可以附接到患者，他们可以通过按正确的顺序按下按钮来操作该装置。

    Two-Part Electrotransport Device
    3.
    发明申请
    Two-Part Electrotransport Device 有权
    两部分电子运输设备

    公开(公告)号：US20120253263A1

    公开(公告)日：2012-10-04

    申请号：US13250031

    申请日：2011-09-30

    申请人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    发明人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    IPC分类号： A61N1/30

    CPC分类号： A61N1/08 ,  A61N1/0412 ,  A61N1/0448 ,  A61N1/325 ,  Y10T29/49117

    摘要： A switch operated therapeutic agent delivery device is described. The device comprises two parts, which are assembled by a user prior to use. A first part contains a power supply and circuitry for the device; and a second part comprises electrodes and reservoirs containing the therapeutic agent to be delivered. The action of combining the two parts of the device causes the two parts to be irreversibly coupled together, completes an electrical connection between the two parts, and closes one or more switches, thereby connecting a power source, such as a battery, into the device's circuitry, thereby powering the device on so that it is ready for use. The device can then be attached to a patient, who can operate the device by pressing a button in a proper sequence.

    摘要翻译： 描述了开关操作的治疗剂递送装置。 该装置包括两个部件，它们在使用之前由使用者组装。 第一部分包含设备的电源和电路; 并且第二部分包括含有要递送的治疗剂的电极和储存器。 组合装置的两个部分的动作导致两个部分不可逆地耦合在一起，完成两部分之间的电连接，并闭合一个或多个开关，从而将诸如电池的电源连接到装置的 电路，从而为设备供电以使其准备使用。 然后，该装置可以附接到患者，他们可以通过按正确的顺序按下按钮来操作该装置。

    TWO-PART ELECTROTRANSPORT DEVICE
    4.
    发明申请
    TWO-PART ELECTROTRANSPORT DEVICE 有权
    两部分电子输送装置

    公开(公告)号：US20140115882A1

    公开(公告)日：2014-05-01

    申请号：US14002909

    申请日：2012-03-09

    申请人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    发明人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    IPC分类号： A61N1/04 ,  A61N1/32

    CPC分类号： A61N1/08 ,  A61N1/0412 ,  A61N1/0448 ,  A61N1/325 ,  Y10T29/49117

    摘要： A switch operated therapeutic agent delivery device is described. The device comprises two parts, which are assembled by a user prior to use. A first part contains a power supply and circuitry for the device; and a second part comprises electrodes and reservoirs containing the therapeutic agent to be delivered. The action of combining the two parts of the device causes the two parts to be irreversibly coupled together, completes an electrical connection between the two parts, and closes one or more switches, thereby connecting a power source, such as a battery, into the device's circuitry, thereby powering the device on so that it is ready for use. The device can then be attached to a patient, who can operate the device by pressing a button in a proper sequence.

    摘要翻译： 描述了开关操作的治疗剂递送装置。 该装置包括两个部件，它们在使用之前由使用者组装。 第一部分包含设备的电源和电路; 并且第二部分包括含有要递送的治疗剂的电极和储存器。 组合装置的两个部分的动作导致两个部分不可逆地耦合在一起，完成两部分之间的电连接，并闭合一个或多个开关，从而将诸如电池的电源连接到装置的 电路，从而为设备供电以使其准备使用。 然后，该装置可以附接到患者，他们可以通过按正确的顺序按下按钮来操作该装置。

    Current control for electrotransport drug delivery
    5.
    发明授权
    Current control for electrotransport drug delivery 有权
    电输送药物输送的电流控制

    公开(公告)号：US08428709B1

    公开(公告)日：2013-04-23

    申请号：US13493314

    申请日：2012-06-11

    申请人： Bradley E. White ,  Paul Hayter ,  John Lemke ,  Scot Satre ,  Corinna X. Chen ,  Brian W. Read ,  Jason E. Dougherty

    发明人： Bradley E. White ,  Paul Hayter ,  John Lemke ,  Scot Satre ,  Corinna X. Chen ,  Brian W. Read ,  Jason E. Dougherty

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/025 ,  A61N1/30

    摘要： Devices, systems and methods for controlling the application of current and/or voltage to deliver drug from patient contacts of an electrotransport drug delivery device by indirectly controlling and/or monitoring the applied current without directly measuring from the cathode of the patient terminal. In particular, described herein are electrotransport drug delivery systems including constant current delivery systems having a feedback current and/or voltage control module that is isolated from the patient contacts (e.g., anodes and cathodes). The feedback module may be isolated by a transistor from the patient contacts; feedback current and/or voltage control measurements may be performed at the transistor rather than at the patient contact (e.g., cathode).

    摘要翻译： 用于控制电流和/或电压的应用的装置，系统和方法，以通过间接地控制和/或监测所施加的电流而不直接从患者终端的阴极测量来输送药物从电输送药物递送装置的患者接触。 特别地，本文所描述的是电传输药物递送系统，其包括具有与患者接触（例如阳极和阴极）隔离的反馈电流和/或电压控制模块的恒流输送系统。 反馈模块可以由患者接触器的晶体管隔离; 反馈电流和/或电压控制测量可以在晶体管而不是在患者接触（例如阴极）处进行。

    Biosensing meter with ambient temperature estimation method and system
    8.
    发明授权
    Biosensing meter with ambient temperature estimation method and system 失效
    具有环境温度估计方法和系统的生物传感仪

    公开(公告)号：US5405511A

    公开(公告)日：1995-04-11

    申请号：US073179

    申请日：1993-06-08

    申请人： Bradley E. White ,  Michael L. Brown ,  Paul G. Ritchie ,  Vladimir Svetnik ,  Robert A. Parks ,  Stefan Weinert

    发明人： Bradley E. White ,  Michael L. Brown ,  Paul G. Ritchie ,  Vladimir Svetnik ,  Robert A. Parks ,  Stefan Weinert

    IPC分类号： G01N27/26 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487

    CPC分类号： G01N27/3274 ,  G01K7/42

    摘要： A biosensing meter is provided that determines a value of an analyte in a biological sample. The meter employs an algorithm for determining the analyte value, which value is dependent upon ambient temperature about the biological sample when it is present in a reaction zone. The biosensing meter includes a processor and a temperature sensor. The temperature sensor is positioned within the meter's structure and thereby exhibits a delayed response to changes in the ambient temperature. The meter performs a temperature estimation method to overcome the delayed temperature response. The method commences by the meter repetitively and periodically acquiring temperature readings from the temperature sensor when the biosensing meter is both in an on state and in an off state. When the meter is in the on state, the algorithm estimates the ambient temperature by employing at least two most recent temperature readings and extrapolating therefrom to achieve an ambient temperature estimate. Temperature readings are acquired by the meter at first intervals when the meter is in the off state and at second, shorter intervals when the meter is in the on state, the temperature extrapolations only occurring when the meter is in the on state.

    摘要翻译： 提供了生物传感计，其确定生物样品中分析物的值。 仪表采用一种用于确定分析物值的算法，该值取决于生物样品当存在于反应区域时的环境温度。 生物传感计包括处理器和温度传感器。 温度传感器位于仪表结构内，从而对环境温度的变化表现出延迟的响应。 仪表执行温度估计方法以克服延迟温度响应。 当生物传感仪处于打开状态并处于关闭状态时，该仪器重复开始并周期性地从温度传感器获取温度读数。 当仪表处于打开状态时，该算法通过采用至少两个最近的温度读数来估计环境温度，并从中推断出来以实现环境温度估计。 当仪表处于关闭状态时，仪表以第一时间间隔获取温度读数，当仪表处于打开状态时以秒为单位，温度外推仅在仪表处于打开状态时发生。

    Biosensing meter with fail/safe procedures to prevent erroneous indications
    9.
    发明授权
    Biosensing meter with fail/safe procedures to prevent erroneous indications 失效
    生物传感仪具有故障/安全程序，以防止错误的指示

    公开(公告)号：US5352351A

    公开(公告)日：1994-10-04

    申请号：US73180

    申请日：1993-06-08

    申请人： Bradley E. White ,  Robert A. Parks ,  Paul G. Ritchie ,  Vladimir Svetnik

    发明人： Bradley E. White ,  Robert A. Parks ,  Paul G. Ritchie ,  Vladimir Svetnik

    IPC分类号： G01N27/26 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487

    CPC分类号： G01N27/3273

    摘要： A biosensing meter receives a sample strip that includes electrically isolated sense and excitation electrodes bridged by a reaction zone. When a drop of biological sample fluid is placed in the reaction zone, a plurality of fail/safe tests are performed. A drop size test is performed by a circuit that detects the size of the drop placed in the reaction zone. The circuit both detects that a drop has been placed in the reaction zone and further measures a test current level, after a delay, to determine that the drop size is sufficient to enable hydration of reactants in the reaction zone. Subsequently, during the reaction, a "delta" current change is measured at succeeding sample time. This test measures the difference between succeeding current samples during a measurement time. If each succeeding sample is not less than preceding sample by a delta value, a determination is made that the current is not monotonically decreasing and the test is aborted. At the termination of the measurement time, a current sum test is performed wherein a processor calculates a linear sum of all sample test currents and calculates a ratio between that sum and the last current sample. If that ratio matches a pre-calculated constant for the Cottrell relationship, then it is known that the measurement values exhibit the Cottrell relationship.

    摘要翻译： 生物传感仪接收包含由反应区桥接的电隔离的感应和激发电极的样品条。 当将一滴生物样品流体置于反应区域中时，进行多次故障/安全试验。 通过检测放置在反应区中的液滴尺寸的电路进行液滴尺寸测试。 电路两者都检测到液滴已经放置在反应区域中，并且在延迟之后进一步测量测试电流水平，以确定液滴尺寸足以使反应物质在反应区域中水合。 随后，在反应期间，在随后的采样时间测量“delta”电流变化。 该测试测量测量时间中后续电流样本之间的差异。 如果每个后续样本不小于先前样本的Δ值，则确定电流不是单调递减，并且测试中止。 在测量时间结束时，执行电流和测试，其中处理器计算所有采样测试电流的线性和，并且计算该和与最后一个当前采样之间的比率。 如果该比率匹配Cottrell关系的预先计算的常数，则已知测量值表现出Cottrell关系。

    Biosensor electrode excitation circuit
    10.
    发明授权
    Biosensor electrode excitation circuit 失效
    生物传感器电极激励电路

    公开(公告)号：US4999582A

    公开(公告)日：1991-03-12

    申请号：US451108

    申请日：1989-12-15

    申请人： Robert A. Parks ,  Bradley E. White

    发明人： Robert A. Parks ,  Bradley E. White

    IPC分类号： G01N27/416 ,  G01N27/327 ,  G01N33/487 ,  G01R27/02

    CPC分类号： G01N27/3273

    摘要： A circuit is described for applying a potential to an electrode of a biosensing test cell, which electrode, when properly inserted in a female connector, is contacted by a pair spaced apart contacts. The circuit includes a source of excitation potential and an operational amplifier having one input connected to the source of excitation potential. A switching circuit is coupled between the operational amplifier and a first one of the spaced apart contacts, with the switch means exhibiting an impedance. A feedback circuit is connected between the second of the spaced-apart contacts and another input to the operational amplifier, to feed back a potential appearing at the second contact. The feedback is for the purpose of maintaining the output of the operational amplifier at a level which compensates for impedance losses in the swtiching circuit. The feedback circuit enables the output of the operational amplifier to be varied so that the potential applied to the electrode is equal to the source of excitation potential. A further circuit is connected to the feedback circuit for sensing when an open or high impedance state exists between the spaced-apart contacts.

    摘要翻译： 描述了将电位施加到生物传感测试电池的电极的电路，当适当地插入阴连接器中时，该电极被一对间隔开的触点接触。 该电路包括一个激励电位源和一个运算放大器，其中一个输入端连接到激励电位源。 开关电路耦合在运算放大器和间隔开的触点中的第一个之间，开关装置呈现阻抗。 反馈电路连接在第二间隔开的触点和另一个输入到运算放大器之间，以反馈在第二个触点处出现的电位。 反馈是为了将运算放大器的输出保持在补偿开关电路中的阻抗损耗的水平。 反馈电路使运算放大器的输出变化，使得施加到电极的电位等于激励电位源。 另一个电路连接到反馈电路，用于在间隔开的触点之间存在开路或高阻抗状态时进行感测。