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    PARTICLE INDUCED RADIOGRAPHY SYSTEM
    5.
    发明申请
    PARTICLE INDUCED RADIOGRAPHY SYSTEM 有权

    公开(公告)号：US20220390628A1

    公开(公告)日：2022-12-08

    申请号：US17805869

    申请日：2022-06-08

    申请人： Academia Sinica ,  National Central University

    发明人： Mythra Varun Nemallapudi ,  Chih-Hsun Lin ,  Shih-Chang Lee ,  Augustine Ei-fong Chen

    IPC分类号： G01T1/20

    摘要： The invention is related to particle induced radiography system, comprising a particle radiation source device, implant module, external detector device, central module and other controls, in which the implant module comprises active and/or passive components in tandem with the readout electronics and communication chosen to measure the beam properties and to generate and detect secondary gamma photons from the nuclear interactions, the external detector device provides a position sensitive gamma detector with a high detection efficiency, good spatial resolution and a relatively large field of view necessary for particle treatments useful in monitoring both the implanted device and the patient anatomical areas under treatment, and the external detector device can also be used to perform 3D spectral imaging on any material samples using proton beam as a probe.

    Harmonic light-generating metasurface
    6.
    发明授权
    Harmonic light-generating metasurface 有权

    公开(公告)号：US11500265B2

    公开(公告)日：2022-11-15

    申请号：US17281814

    申请日：2019-10-01

    申请人： William Marsh Rice University ,  Academia Sinica

    发明人： Michael Semmlinger ,  Ming-Lun Tseng ,  Jian Yang ,  Ming Zhang ,  Din Ping Tsai ,  Liangliang Dong ,  Arash Ahmadivand ,  Peter Nordlander ,  Naomi Jean Halas

    IPC分类号： G02F1/35 ,  G02F1/37

    摘要： A harmonic light-generating metasurface includes a base substrate and a plurality of structures, that include nonlinear material, that are disposed in a pattern on a surface of the base substrate. Each structure of the plurality of structures individually supports a magnetic dipole mode. An electromagnetic field enhancement of the magnetic dipole mode induces generation of a harmonic signal by the plurality of structures. Alternatively, a harmonic light-generating metasurface, includes a base substrate, a supporting substrate that includes a nonlinear material, and a plurality of paired structures disposed in a pattern on a surface of the supporting substrate. Each paired structure, of the plurality of paired structures, collectively supports a toroidal dipole mode. An electromagnetic field enhancement of the toroidal dipole mode penetrates the supporting substrate to induce generation of a harmonic signal by the supporting substrate.

    PEPTIDE-LOADED CARRIER SYSTEMS AND USES THEREOF
    8.
    发明申请
    PEPTIDE-LOADED CARRIER SYSTEMS AND USES THEREOF 有权

    公开(公告)号：US20220267478A1

    公开(公告)日：2022-08-25

    申请号：US17631698

    申请日：2020-07-29

    申请人： Academia Sinica

    发明人： Che-ming Jack Hu ,  Chien-wei Lin ,  Jung-chen Lin ,  Chen-hsueh Pai

    IPC分类号： C07K17/08 ,  A61K47/62 ,  A61K47/69 ,  C07K17/04 ,  A61P31/16 ,  A61P35/00

    摘要： A carrier system that includes a nanocarrier and a peptide non-covalently associated with the nanocarrier. The peptide contains an adaptor peptide sequence fused to the N-terminus of a target peptide, the adaptor peptide sequence being designed to facilitate the association to the nanocarrier. Also disclosed is a method for improving the immunogenicity of a peptide antigen by fusing it to an adaptor peptide sequence to form an immunizing peptide and contacting the immunizing peptide with a compatible nanocarrier. Further, a method is provided for treating a condition by immunization with a target peptide that has been fused to an adaptor peptide sequence and thereby associated with a nanocarrier. The method induces an immune response against the target peptide for treating cancer, viral infection, bacterial infection, parasitic infection, autoimmunity, or undesired immune responses to a biologies treatment.

    CHIMERIC HEMAGGLUTININ PROTEIN AND A VACCINE COMPOSITION COMPRISING THE SAME
    9.
    发明申请
    CHIMERIC HEMAGGLUTININ PROTEIN AND A VACCINE COMPOSITION COMPRISING THE SAME 有权

    公开(公告)号：US20220267382A1

    公开(公告)日：2022-08-25

    申请号：US17627212

    申请日：2020-09-18

    申请人： ACADEMIA SINICA

    发明人： Yu-Chan CHAO ,  Chih-Hsuan TSAI ,  Chia-Jung CHANG ,  Sung-Chan WEI ,  Lin-Li LIAO ,  Huei-Ru LO

    IPC分类号： C07K14/005 ,  A61P31/16

    摘要： Provided is a chimeric hemagglutinin (HA) protein including an HA1 subunit and an HA2 subunit, in which the HA1 subunit is composed of a first domain derived from a parental HA1 subunit of a first subtype influenza virus and a second domain derived from a parental HA1 subunit of a second subtype influenza virus. The chimeric HA protein has improved thermal stability and can be used in a vaccine composition for preventing influenza virus infection. Also provided is a method of inducing an immune response against an influenza virus in a subject in need thereof that includes administering the chimeric HA protein to the subject, thereby conferring protection against the influenza virus infection on the subject.