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公开(公告)号：US07235056B2
公开(公告)日：2007-06-26
申请号：US10128780
申请日：2002-04-23
IPC分类号： A61B5/00
CPC分类号： A61B10/0045 , A61B5/14532 , A61B5/150022 , A61B5/150152 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150717 , A61B5/150824 , A61B5/15111 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/15194 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A device for sampling body fluid includes a housing having a sleeve at a forward end thereof which is displaceable in response to being pressed against a user's skin to trigger the firing of a lancet. After the lancet is removed from the incision, the sleeve is repeatedly pressed against the skin to depress a ring of body tissue in surrounding relationship to the incision to express body fluid outwardly through the incision. A pusher member is then actuated to push a capillary tube through a front end of the housing for drawing-in body fluid. The lancet is a disposable lancet which includes a body supporting a skin-lancing member and the capillary tube. The disposable lancet passes through an upper end of a lancet carrier when being installed or removed. The device cannot be armed until the disposable lancet is installed in the housing, because the capillary tube functions to push a safety device to a non-safety position.
摘要翻译： 用于体液取样的装置包括：壳体，其在其前端具有套筒，该壳体可响应于压靠使用者的皮肤而移位以触发刺血针的点燃。 在从切口中取出刺血针之后，套筒被重复地压在皮肤上，以与切口围绕的关系压下身体组织环，以通过切口向外表达体液。 然后致动推动器构件以推动毛细管穿过壳体的前端以吸入体液。 柳叶刀是一次性的柳叶刀，其包括支撑皮肤穿刺部件和毛细管的主体。 当安装或拆卸时，一次性柳叶刀穿过柳叶刀托架的上端。 由于毛细管的作用是将安全装置推到非安全位置，因此该装置将不会挂起，直到一次性的柳叶刀安装在外壳中。
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公开(公告)号：US6162639A
公开(公告)日：2000-12-19
申请号：US215686
申请日：1998-12-18
申请人： Joel S. Douglas
发明人： Joel S. Douglas
IPC分类号： G01N31/22 , B01L3/00 , C12Q1/54 , G01N33/52 , G01N33/66 , C12M1/00 , G01N21/00 , G01N33/531 , G01N33/543
CPC分类号： G01N33/525 , B01L3/5023 , B01L3/5027 , B01L2200/0605 , B01L2200/0689 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , C12Q1/54 , G01N33/66 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/808 , Y10S436/809 , Y10S436/81 , Y10S436/823 , Y10T436/117497
摘要： The invention provides a method for measuring the amount of analyte in a sample of biological fluid using a simple low sample volume reagent test strip with a built in metering system. The test strip may include a microtitration zone to prevent oversampling and an integrated capillary to prevent problems associated with short sampling and act as means of absorbing the fluid sample. The test strip comprises a wicking layer and a reaction matrix embossed layer in the form of a pillow assembled into a microtitration pocket formed in the strip. The test strip is used in single use applications such as the determination of the concentration of glucose in blood.
摘要翻译： 本发明提供一种使用具有内置计量系统的简单的低样本体积试剂测试条来测量生物流体样品中分析物的量的方法。 测试条可以包括微量滴定区以防止过采样和集成毛细管以防止与短取样相关的问题，并且作为吸收流体样品的手段。 测试条包括芯组形式的芯吸层和反应基质压花层，所述枕头组装成形成在条带中的微量滴定袋。 测试条用于单次使用应用中，例如测定血液中葡萄糖的浓度。
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公开(公告)号：US6099484A
公开(公告)日：2000-08-08
申请号：US298386
申请日：1999-04-23
CPC分类号： B82Y30/00 , A61B10/0045 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150343 , A61B5/150419 , A61B5/150427 , A61B5/150519 , A61B5/150824 , A61B5/150977 , A61B5/15111 , A61B5/15117 , A61B5/15194 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper end of the capillary tube for receiving the fluid. An absorbent pad can be disposed between the test strip and capillary tube for spreading-out the fluid being transferred to the test strip. An on-site analyzer such as an optical analyzer and/or an electrochemical analyzer can be mounted in the device for analyzing the fluid. Alternatively, a test strip can be slid through a slot formed in the bottom end of the device so that by passing the device against the skin after an incision has been formed, the test strip will directly contact body fluid emanating from the incision.
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公开(公告)号：US6056701A
公开(公告)日：2000-05-02
申请号：US204909
申请日：1998-12-03
CPC分类号： A61B5/15186 , A61B10/0045 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150083 , A61B5/150343 , A61B5/150412 , A61B5/15109 , A61B5/15117 , A61B5/15194 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A device for sampling body fluid includes a housing having a sleeve at a forward end thereof which is displaceable in response to being pressed against a user's skin to trigger the firing of a lancet. After the lancet is removed from the incision, the sleeve is repeatedly pressed against the skin to depress a ring of body tissue in surrounding relationship to the incision to express body fluid outwardly through the incision. A pusher member is then actuated to push a capillary tube through a front end of the housing for drawing-in body fluid. The lancet is a disposable lancet which includes a body supporting a skin-lancing member and the capillary tube. The disposable lancet passes through an upper end of a lancet carrier when being installed or removed. The device cannot be armed until the disposable lancet is installed in the housing, because the capillary tube functions to push a safety device to a non-safety position.
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公开(公告)号：US6106780A
公开(公告)日：2000-08-22
申请号：US228814
申请日：1999-01-11
IPC分类号： G01N33/49 , A61B5/00 , C12Q1/54 , G01D3/02 , G01N21/01 , G01N21/78 , G01N21/86 , G01N27/28 , G01N27/327 , G01N31/22 , G01N33/48 , G01N33/487 , G01N33/52 , G01N33/66 , G01N35/00 , G01N37/00 , G01N21/00
CPC分类号： G01N33/528 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/150259 , A61B5/150305 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/15186 , A61B5/157 , A61B5/415 , C12Q1/54 , G01D3/022 , G01N21/8483 , G01N33/48757 , G01N33/48771 , G01N33/525 , G01N33/66 , A61B2560/0431 , A61B2562/0295 , A61B2562/085 , A61B5/150503 , G01N2035/00138 , Y10S435/808 , Y10S435/817
摘要： An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.
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公开(公告)号：US6071250A
公开(公告)日：2000-06-06
申请号：US238140
申请日：1999-01-28
申请人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
发明人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
CPC分类号： A61B5/14532 , A61B10/0045 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150412 , A61B5/15109 , A61B5/15117 , A61B5/15186 , A61B5/15194 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.
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公开(公告)号：US6121011A
公开(公告)日：2000-09-19
申请号：US205556
申请日：1998-12-04
申请人： Joel S. Douglas , John M. Gleisner
发明人： Joel S. Douglas , John M. Gleisner
CPC分类号： C12Q1/26 , G01N33/521 , C12Q2326/32 , Y10S435/968
摘要： This invention provides methods and apparatus for applying a reagent to an analytical test device. The methods and apparatus employ a nozzle and a flexible restrictor to accurate control the amount of reagent applied to the test device. The analytical test devices prepared by the methods of this invention are used to determine the presence or the quantity of an analyte in a liquid sample, such as whole blood.
摘要翻译： 本发明提供了将试剂施加到分析测试装置的方法和装置。 所述方法和装置采用喷嘴和柔性限制器来精确地控制施加到测试装置的试剂的量。 通过本发明方法制备的分析测试装置用于确定液体样品如全血中分析物的存在或数量。
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公开(公告)号：US6066103A
公开(公告)日：2000-05-23
申请号：US285021
申请日：1999-04-01
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150099 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15111 , A61B5/15117 , A61B5/1519 , A61B5/150633
摘要： Body fluid is sampled from a skin incision by placing a ring against the skin and repeatedly applying an elastic pressing force to the ring, whereby a stimulator surface of the ring depresses a ring of skin and body tissue in surrounding relationship to the incision to force body fluid from the incision. The stimulator surface is inclined at an angle of 10 to 65 degrees; a width of the stimulator surface is from 5 mm to 20 mm, and an inner diameter of the stimulator surface is no less than 6.0 mm.
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9.发明授权Methods for analyzing blood to detect diseases associated with abnormal protein aggregation 有权分析血液以检测与异常蛋白质聚集有关的疾病的方法公开(公告)号：US09588129B2
公开(公告)日：2017-03-07
申请号：US13833008
申请日：2013-03-15
发明人： Peter Stys , Shigeki Tsutsui
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821 , G01N2800/2828 , G01N2800/2835 , G01N2800/2842 , G01N2800/285 , G06F19/18
摘要： A method of detecting a disease associated with abnormal protein aggregation in a subject is provided, the method comprising (a) contacting leukocytes from the subject with a probe that binds to pathogenic protein aggregates, and (b) detecting the probe bound to the pathogenic protein aggregates, wherein the presence of pathogenic protein aggregates in the leukocytes is indicative that the subject has a disease associated with abnormal protein aggregation. In one embodiment, the disease is Alzheimer's disease or mild cognitive impairment.
摘要翻译： 提供了检测与受试者异常蛋白质聚集有关的疾病的方法，所述方法包括（a）将来自受试者的白细胞与结合致病性蛋白质聚集体的探针接触，和（b）检测与病原蛋白结合的探针 聚集体，其中白细胞中病原蛋白聚集体的存在表明受试者具有与异常蛋白质聚集相关的疾病。 在一个实施方案中，该疾病是阿尔茨海默氏病或轻度认知障碍。
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公开(公告)号：USD427312S
公开(公告)日：2000-06-27
申请号：US97453
申请日：1998-12-07
申请人： Joel S. Douglas
设计人： Joel S. Douglas
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