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公开(公告)号：US10702628B2
公开(公告)日：2020-07-07
申请号：US15668716
申请日：2017-08-04
摘要： A biomaterial for the treatment of spinal cord or of peripheral nerve injury, obtainable by: a) treating a hyaluronic acid derivative with a coating solution promoting Neuronal Stem Cells adhesion, branching and differentiation; b) contacting isolated Neuronal Stem Cells with the hyaluronic acid derivative obtained from step a) and culturing and expanding the absorbed cells in the presence of growth or neurotrophic factors selected from βFGF (basic fibroblast growth factor), CNTF (ciliary neurotrophic factor), BDNF (brain derived neurotrophic factor) and GDNF (glial derived neurotrophic factor) or mixtures thereof.
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公开(公告)号：US08349355B2
公开(公告)日：2013-01-08
申请号：US11921247
申请日：2006-05-24
CPC分类号： A61L26/0066 , A61K31/385 , A61K31/728 , A61L15/28 , A61L15/44 , A61L26/0023 , A61L2300/21 , A61K2300/00 , C08L5/08
摘要： The present invention relates to novel formulations comprising lipoic acid and hyaluronic acid and/or the derivatives thereof for use in the repair of chronic ulcers, the regeneration of damaged skin, the prevention of skin aging and, when administered by the systemic route, to treat peripheral neuropathies and intoxications by chemical and/or biological agents.
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公开(公告)号：US20220168105A1
公开(公告)日：2022-06-02
申请号：US17456901
申请日：2021-11-30
发明人： Stefano Agnello , Edward Ahn , Matteo Centola , Steven W. Ek , Stephen J. Kennedy , Matthew M. Mannarino , Elvira Marchetto , Sonali Puri , Robert Richard , Sara Simoncioni
摘要： A bioabsorbable textile for the restoration of the joint function whereas the joint is affected by partial thickness tears, small to medium full-thickness tears, large to massive full-thickness tears, acute and chronic/degenerative tears. The bioabsorbable textile may comprise polymeric yarns interconnected to form a weave or knitted configuration, wherein said bioabsorbable textile provides a combined mechanical and biological augmentation in the target joint tissue. The bioabsorbable textile may be implanted in combination with fixation tools during open, mini-open or arthroscopic repair/augmentation procedures of joint tissue tears.
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4.发明授权Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions 有权由硫酸化透明质酸和结冷胶组成的生物材料用于预防脊髓粘连公开(公告)号：US08563039B2
公开(公告)日：2013-10-22
申请号：US11664754
申请日：2005-10-03
CPC分类号： A61K31/728 , A61K31/715 , A61K31/737 , A61K31/795 , A61K45/06 , A61L31/041 , A61L31/042 , A61K2300/00 , C08L5/08 , C08L5/00
摘要： New biomaterials consisting of a combination of sulphated hyaluronic acid and gellan (as well as gellan that has not been associated with other polymers), to be used as a highly effective barrier to prevent post-surgical adhesions in abdominal, pelvic and, above all, spine surgery.
摘要翻译： 由硫酸化透明质酸和结冷胶组合的新生物材料（以及与其他聚合物没有关联的结冷胶）被用作防止腹部，骨盆内的手术后粘连的高效屏障， 脊柱手术。
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5.发明申请BIOMATERIALS CONSISTING OF SULPHATED HYALURONIC ACID AND GELLAN TO BE USED IN THE PREVENTION OF SPINAL ADHESIONS 有权包含用于预防脊髓粘连的硫酸羟丙酸和凝胶的生物制剂公开(公告)号：US20130184234A1
公开(公告)日：2013-07-18
申请号：US13468405
申请日：2012-05-10
IPC分类号： A61K31/728 , A61K45/06
CPC分类号： A61K31/728 , A61K31/715 , A61K31/737 , A61K31/795 , A61K45/06 , A61L31/041 , A61L31/042 , A61K2300/00 , C08L5/08 , C08L5/00
摘要： New biomaterials consisting of a combination of sulphated hyaluronic acid and gellan (as well as gellan that has not been associated with other polymers), to be used as a highly effective barrier to prevent post-surgical adhesions in abdominal, pelvic and, above all, spine surgery.
摘要翻译： 由硫酸化透明质酸和结冷胶组合的新生物材料（以及与其他聚合物没有关联的结冷胶）被用作防止腹部，骨盆内的手术后粘连的高效屏障， 脊柱手术。
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6.发明授权Biomaterials, their preparation by electrospinning and their use in the biomedical and surgical field 有权生物材料，它们通过静电纺丝制备及其在生物医学和外科领域的应用公开(公告)号：US08865964B2
公开(公告)日：2014-10-21
申请号：US13056541
申请日：2009-07-24
CPC分类号： A61L27/60 , Y10T442/3065 , Y10T442/614 , Y10T442/626
摘要： There is described a new non-woven fabric produced with the electrospinning technique, and the use thereof as new biomaterial for the biomedical and surgical field.
摘要翻译： 描述了一种用静电纺丝技术生产的新型无纺织物，并将其用作生物医学和外科领域的新生物材料。
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公开(公告)号：US20180140741A1
公开(公告)日：2018-05-24
申请号：US15668716
申请日：2017-08-04
摘要： A biomaterial for the treatment of spinal cord or of peripheral nerve injury injury, obtainable by: a) treating a hyaluronic acid derivative with a coating solution promoting Neuronal Stem Cells adhesion, branching and differentiation; b) contacting isolated Neuronal Stem Cells with the hyaluronic acid derivative obtained from step a) and culturing and expanding the absorbed cells in the presence of growth or neurotrophic factors selected from βFGF (basic fibroblast growth factor), CNTF (ciliary neurotrophic factor), BDNF (brain derived neurotrophic factor) and GDNF (glial derived neurotrophic factor) or mixtures thereof.
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8.发明授权Biocompatible material and prosthetic device made thereof for the replacement, repair and regeneration of meniscus 有权由其制成的生物相容性材料和假体装置用于更换，修复和再生半月板公开(公告)号：US08901202B2
公开(公告)日：2014-12-02
申请号：US11793409
申请日：2005-12-14
IPC分类号： A61F2/00 , A61L24/00 , C08B37/00 , C08G63/48 , A61F2/38 , A61F2/30 , A61L27/26 , A61L27/34 , A61L27/48 , A61L27/56 , A61F2/28
CPC分类号： A61F2/3872 , A61F2/30756 , A61F2/30965 , A61F2002/2867 , A61F2002/30062 , A61F2002/30133 , A61F2002/30957 , A61F2002/30971 , A61F2210/0004 , A61F2230/0015 , A61F2310/00365 , A61L27/26 , A61L27/34 , A61L27/48 , A61L27/56 , C08L67/04 , C08L5/08
摘要： Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-εCaprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.
摘要翻译： 本文描述了一种生物相容性材料，其包含基于透明质酸衍生物和聚己内酯的聚合物基质，该制备该材料的方法，由该生物相容性材料和增强材料构成的假体装置，制备该假体装置的方法， 并用于部分或全部更换半月板，再生半月板纤维软骨。
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9.发明授权Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions 有权由硫酸化透明质酸和结冷胶组成的生物材料用于预防脊髓粘连公开(公告)号：US08728524B2
公开(公告)日：2014-05-20
申请号：US13468405
申请日：2012-05-10
IPC分类号： A61K9/14 , A61K9/00 , A61K31/715 , A61K47/00
CPC分类号： A61K31/728 , A61K31/715 , A61K31/737 , A61K31/795 , A61K45/06 , A61L31/041 , A61L31/042 , A61K2300/00 , C08L5/08 , C08L5/00
摘要： New biomaterials consisting of a combination of sulphated hyaluronic acid and gellan (as well as gellan that has not been associated with other polymers), to be used as a highly effective barrier to prevent post-surgical adhesions in abdominal, pelvic and, above all, spine surgery.
摘要翻译： 由硫酸化透明质酸和结冷胶组合的新生物材料（以及与其他聚合物没有关联的结冷胶）被用作防止腹部，骨盆内的手术后粘连的高效屏障， 脊柱手术。
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