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    CLEANING METHOD, CONTROL APPARATUS AND CONNECTING DEVICE
    1.
    发明申请
    CLEANING METHOD, CONTROL APPARATUS AND CONNECTING DEVICE 审中-公开

    公开(公告)号：US20180236386A1

    公开(公告)日：2018-08-23

    申请号：US15522960

    申请日：2015-10-14

    申请人： BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG

    发明人： Rainer BAUER

    IPC分类号： B01D46/00 ,  B01D46/10 ,  B01D46/04 ,  B01D46/42

    CPC分类号： B01D46/002 ,  B01D46/0019 ,  B01D46/0065 ,  B01D46/0068 ,  B01D46/04 ,  B01D46/10 ,  B01D46/4272

    摘要： A cleaning method for sectional cleaning of a filter is proposed, the filter having several filter sections, by means of one cleaning process one of the filter sections at a time being cleaned, the filter sections being cleaned within one cleaning cycle in cleaning processes separated in time from one another, the cleaning method having at least two cleaning cycles and both one time interval between the cleaning processes within the respective cleaning cycle and also one time interval between the end of one of the cleaning cycles and the start of a following one of the cleaning cycles being changed, and/or the filter having at least three filter sections, the filter sections being cleaned in cleaning processes separated by time intervals from one another and the time intervals between successive cleaning processes being changed. Moreover a connecting device for connecting a filter to a cleaning device is proposed, the connecting device having one side wall which borders an internal cross section which increases along one longitudinal axis of the connecting device and has openings laterally with assigned major axes.

    Regulatory elements
    2.
    发明授权
    Regulatory elements 有权
    监管要素

    公开(公告)号：US08975391B2

    公开(公告)日：2015-03-10

    申请号：US13773845

    申请日：2013-02-22

    申请人： Barbara Enenkel

    发明人： Barbara Enenkel

    IPC分类号： C07H21/04 ,  C12P1/00 ,  C12P21/06 ,  C12P21/04 ,  C12N5/07 ,  C12N15/67 ,  C12N15/63

    CPC分类号： C12N15/67 ,  C12N15/63

    摘要： The invention concerns novel regulatory elements as well as related vectors and cells. Furthermore, it relates to methods of improving expression of polypeptides from nucleic acids such as cloned genes and to the production of various polypeptides in host cells using said novel regulatory elements. Additionally, the invention relates to uses of said novel regulatory elements as insulators, in gene therapy or for improving host cell lines.

    摘要翻译： 本发明涉及新的调控元件以及相关的载体和细胞。 此外，本发明涉及改善来自核酸如克隆基因的多肽表达以及使用所述新型调控元件在宿主细胞中产生各种多肽的方法。 此外，本发明涉及所述新型调节元件在基因治疗或改善宿主细胞系中的绝缘体的用途。

    INHALER FOR THE ADMINISTRATION OF AN ANTICHOLINERGIC
    4.
    发明申请
    INHALER FOR THE ADMINISTRATION OF AN ANTICHOLINERGIC 审中-公开
    吸入抗真菌药物的药物

    公开(公告)号：US20140116435A1

    公开(公告)日：2014-05-01

    申请号：US14133914

    申请日：2013-12-19

    申请人： Bernd ZIERENBERG

    发明人： Bernd ZIERENBERG

    IPC分类号： A61M15/00 ,  A61K31/46

    CPC分类号： A61M15/0041 ,  A61K9/0075 ,  A61K9/145 ,  A61K31/439 ,  A61M15/0021 ,  A61M15/0026 ,  A61M15/0028 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0075 ,  A61M15/0086 ,  A61M15/0091 ,  A61M2202/064 ,  A61M2205/75

    摘要： An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1, √{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 to 500 μm, and a method of administering an inhalable powder containing tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 pm to 500 μm, the method comprising actuating an inhaler a flow resistance of about 0.01 to 0.1 √{square root over (kPa)} min/L containing the inhalable powder.

    摘要翻译： 一种吸入试剂盒，包括：（a）显示约0.01至0.1，{{平方根（kPa）} min / L的流动阻力的吸入器; 和（b）包含噻托溴铵的可吸入粉末，其与平均粒径为10-500μm的生理上可接受的赋形剂混合，以及将含有噻托溴铵的可吸入粉末与生理上可接受的赋形剂的平均粒径 介于10μm至500μm之间的方法，该方法包括使吸入器的流动阻力为含有可吸入粉末的约0.01至0.1√（平方根（kPa）} min / L）。

    TWO-PIECE METAL CAPSULE FOR ACCOMMODATING PHARMACEUTICAL PREPARATIONS FOR POWDER INHALERS
    8.
    发明申请
    TWO-PIECE METAL CAPSULE FOR ACCOMMODATING PHARMACEUTICAL PREPARATIONS FOR POWDER INHALERS 审中-公开
    用于容纳粉末吸入剂的药物制剂的两层金属胶囊

    公开(公告)号：US20120285451A1

    公开(公告)日：2012-11-15

    申请号：US13479420

    申请日：2012-05-24

    申请人： Dieter HOCHRAINER

    发明人： Dieter HOCHRAINER

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0028 ,  A61M2202/064

    摘要： The invention relates to novel two-piece metal capsules for accommodating pharmaceutical preparations to be used in powder inhalers as well as a method for producing said capsule. The inventive capsules are particularly impermeable to steam and oxygen.

    摘要翻译： 本发明涉及用于容纳用于粉末吸入器的药物制剂的新颖的两件式金属胶囊以及用于生产所述胶囊的方法。 本发明的胶囊对蒸汽和氧气是特别不可渗透的。

    Protein production
    10.
    发明授权
    Protein production 有权
    蛋白质生产

    公开(公告)号：US08221999B2

    公开(公告)日：2012-07-17

    申请号：US12040198

    申请日：2008-02-29

    申请人： Hitto Kaufmann ,  Lore Florin ,  Eric Becker ,  Monilola Olayioye ,  Angelika Hausser ,  Tim Fugmann

    发明人： Hitto Kaufmann ,  Lore Florin ,  Eric Becker ,  Monilola Olayioye ,  Angelika Hausser ,  Tim Fugmann

    IPC分类号： C12P21/06

    CPC分类号： C12N15/63 ,  C07K14/435 ,  C07K14/47 ,  C07K14/4702 ,  C07K16/00 ,  C07K2319/036 ,  C12N15/67 ,  C12N15/85 ,  C12P21/00 ,  C12Q1/68 ,  G01N33/68

    摘要： The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport.

    摘要翻译： 本发明涉及蛋白质生产和细胞培养技术领域。 CERT被确定为体内PKD底物的新颖。 通过PKD在丝氨酸132上的磷酸化降低了CERT对高尔基体膜上的脂质靶磷脂酰肌醇4-磷酸的亲和力，降低了神经酰胺转移活性，鉴定了PKD作为脂质体内平衡的调节剂。 本发明显示CERT又对于PKD激活和PKD依赖蛋白质运送到质膜的关键。 因此，PKD和CERT的相互依存关系是维持高尔基体膜完整性和分泌转运的关键。