公开(公告)号：US20230126580A1

公开(公告)日：2023-04-27

申请号：US17801677

申请日：2021-08-18

申请人： CRANFIELD UNIVERSITY

发明人： Zhugen YANG

IPC分类号： C12Q1/689 ,  B01L3/00 ,  C12Q1/6806

摘要： A method of detecting a pathogen in a water sample. The method includes extracting DNA of the pathogen from a DNA solution derived from a water sample, eluting the DNA through a paper-based microfluidic device having flow channels and then performing LAMP reactions within a set of reaction chambers to obtain LAMP products that may be detected via an amplicon detection test.

公开(公告)号：US20200057010A1

公开(公告)日：2020-02-20

申请号：US16549028

申请日：2019-08-23

申请人： THE NOTTINGHAM TRENT UNIVERSITY ,  CRANFIELD UNIVERSITY

发明人： Paul EVANS ,  Keith ROGERS

IPC分类号： G01N23/20008 ,  G01N23/205

摘要： A sample inspection apparatus irradiates a sample with a conical shell of X-ray or similar radiation generating a plurality of Debye rings originating from a circular path on the sample. The apparatus is provided with two detectors. A first detector receives diffracted radiation and a second detector receives radiation which is transmitted through a coded aperture provided at a detection surface of the first detector.

公开(公告)号：US08462913B2

公开(公告)日：2013-06-11

申请号：US12602760

申请日：2008-06-02

申请人： Paul Evans ,  Keith Rogers

发明人： Paul Evans ,  Keith Rogers

IPC分类号： G01N23/207

CPC分类号： G21K1/02 ,  G21K1/025

摘要： A radiation detecting apparatus includes a collimator and a detector, the collimator having a material for blocking radiation and a region that is a sector of an annulus or multiple regions in a configuration in the shape of a sector of an annulus for allowing transmission of the radiation. The detector is spaced a distance from the collimator such that when a radiation source and sample crystal material are positioned at suitable positions, the radiation is collimated by the collimator and contacts the sample a predetermined distance from the detector at multiple of locations corresponding to the region or regions of the collimator. The Bragg diffracted radiation from the crystal material at two or more and preferably all of the locations overlap at the detector.

摘要翻译： 辐射检测装置包括准直器和检测器，准直器具有用于阻挡辐射的材料，以及作为环形扇形形状的环形或多个区域的区域的区域，用于允许放射线的传播 。 检测器与准直器隔开一段距离，使得当辐射源和样品晶体材料位于合适的位置时，辐射被准直器准直并且在对应于该区域的多个位置处与检测器接触预定距离的检测器 或准直仪的区域。 在两个或更多且优选地所有位置处的晶体材料的布拉格衍射辐射在检测器处重叠。

公开(公告)号：US08086415B2

公开(公告)日：2011-12-27

申请号：US11933913

申请日：2007-11-01

申请人： Beining Chen ,  Richard Michael Day ,  Sreenath Subrahmanyam ,  Sergiy Anatoliyovich Piletsky ,  Olena Volodimirivna Piletska ,  Anthony Peter Francis Turner

发明人： Beining Chen ,  Richard Michael Day ,  Sreenath Subrahmanyam ,  Sergiy Anatoliyovich Piletsky ,  Olena Volodimirivna Piletska ,  Anthony Peter Francis Turner

IPC分类号： G01N31/00

CPC分类号： C08F2/44 ,  C08F251/00 ,  C08F289/00 ,  C08F291/00 ,  G01N2600/00

摘要： A computer aided rational molecular design method that includes establishing a virtual library of functional monomers each having a portion that is capable of polymerizing and a functional group that is capable of interacting with a template molecule with the aid of a computer, designing a molecular model of a biological template molecule by a computer facilitated molecular mechanical method and screening said virtual library of functional monomers and selecting those monomers which have the highest binding score to the template molecule by their functional group.

摘要翻译： 一种计算机辅助合理的分子设计方法，其包括建立一个功能性单体的虚拟文库，每个功能性单体具有能够聚合的部分和能够借助于计算机与模板分子相互作用的官能团，设计分子模型 通过计算机的生物模板分子促进分子机械方法并筛选所述功能单体的虚拟文库，并通过其官能团选择具有最高结合分数的模板分子的那些单体。

公开(公告)号：US07876447B2

公开(公告)日：2011-01-25

申请号：US12018693

申请日：2008-01-23

申请人： Jeremy Joachim Ramsden ,  Yosyp Petrovich Sharkan ,  Serhiy Korposh ,  Mikhaylo Yurievich Sichka ,  Nikolay Borisovich Zhitov

发明人： Jeremy Joachim Ramsden ,  Yosyp Petrovich Sharkan ,  Serhiy Korposh ,  Mikhaylo Yurievich Sichka ,  Nikolay Borisovich Zhitov

IPC分类号： G01B9/02

CPC分类号： G01N21/7703 ,  G01D5/268 ,  G01N21/45 ,  G01N2021/772 ,  G01N2021/7779

摘要： Apparatus for determining a parameter of a sample has an optical sensor in the form of a monofibre waveguide having a distal end coated with a film that is placed in a sample. The waveguide has an input channel connected to a radiation light source and an output channel connected to a photodiode and amplifier to receive signals representative of the interference patterns created at the interface between the film and the sample. A computer receives the signals via an analogue to digital converter for processing the information and providing a measurement of the parameter. The measurement of the parameter may be used to control a process or system.

摘要翻译： 用于确定样品参数的装置具有单体波导形式的光学传感器，其具有涂覆有放置在样品中的膜的远端。 波导具有连接到辐射光源的输入通道和连接到光电二极管和放大器的输出通道，以接收表示在膜和样品之间的界面处产生的干涉图案的信号。 计算机经由模拟数字转换器接收信号以处理信息并提供该参数的测量值。 参数的测量可用于控制过程或系统。

公开(公告)号：US20100173421A1

公开(公告)日：2010-07-08

申请号：US12529579

申请日：2008-02-29

申请人： Sergey Anatoliyovich Piletsky ,  Yves Frederic Henry ,  Khalku Karim ,  Peter Georg Laitenberger

发明人： Sergey Anatoliyovich Piletsky ,  Yves Frederic Henry ,  Khalku Karim ,  Peter Georg Laitenberger

IPC分类号： G01N33/50

CPC分类号： G01N33/54373 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/4821 ,  G01N27/404 ,  G01N2600/00 ,  Y10T436/203332

摘要： This invention relates to a sensor and in particular to a sensor for the detection of biologically important species. Specifically, the invention provides a method for detecting an analyte in the presence of at least one interferent in a sample. The method comprises the steps of providing a sensor having a transducer and a receptor layer in communication with the transducer, in which the receptor layer comprises a material for absorbing the analyte; exposing the receptor layer to the sample; treating the receptor layer to remove selectively the at least one interferent; and measuring the signal from the transducer. The treatment step is performed by applying a change in potential, a change in pH or a change in temperature to the receptor layer, by washing the receptor layer, by irradiating the receptor layer, or a combination thereof.

摘要翻译： 本发明涉及一种传感器，特别涉及用于检测生物重要物种的传感器。 具体地，本发明提供了一种在样品中存在至少一种干扰物的情况下检测分析物的方法。 该方法包括以下步骤：提供具有换能器和与换能器连通的受体层的传感器，其中接收层包括用于吸收分析物的材料; 将受体层暴露于样品; 处理所述受体层以选择性地除去所述至少一种干扰物; 并测量传感器的信号。 处理步骤是通过对受体层进行洗涤，照射受体层或其组合来施加电位变化，pH变化或温度变化对受体层进行的。

公开(公告)号：US20090082480A1

公开(公告)日：2009-03-26

申请号：US11916948

申请日：2006-06-06

申请人： Sergey Anatoliyovich Piletsky ,  Olena Volodimirivna Piletska ,  Anthony Peter Francis Turner ,  Igor Dubey ,  Larysa Dubey

发明人： Sergey Anatoliyovich Piletsky ,  Olena Volodimirivna Piletska ,  Anthony Peter Francis Turner ,  Igor Dubey ,  Larysa Dubey

IPC分类号： C08L33/08 ,  C08F8/12

CPC分类号： C08F8/12 ,  C08F2810/20 ,  C08F2810/50 ,  C08F212/36 ,  C08F2222/102 ,  C08F8/44

摘要： A monomer having a pair of hydroxy groups held in a fixed relationship (e.g. a dihydroxybenzene) is diesterified with a compound having a polymerisable group, e.g. to form a diacrylate. After polymerisation with a crosslinker, the polymer is hydrolysed. The dihydroxy-monomer is removed, leaving a polymer with pair of carboxyl groups held in spatial relationships determined by the dihydroxy monomer. Thus a range of subtly different polymers can be prepared by using different dihydroxy-monomer templates. The polymers are desirably swellable. They can be used as selective binding materials, e.g. in chromatography or analysis.

摘要翻译： 具有固定关系的一对羟基（例如二羟基苯）的单体用具有可聚合基团的化合物， 以形成二丙烯酸酯。 用交联剂聚合后，聚合物被水解。 除去二羟基单体，留下具有由二羟基单体确定的空间关系的一对羧基的聚合物。 因此，可以通过使用不同的二羟基单体模板制备一系列微妙不同的聚合物。 聚合物希望是可溶胀的。 它们可以用作选择性结合材料，例如 在色谱或分析中。

公开(公告)号：US20060122288A1

公开(公告)日：2006-06-08

申请号：US10507698

申请日：2003-03-24

申请人： Sergey Piletsky ,  Olena Piletska ,  Anthony Turner ,  Khalku Karim ,  Beining Chen

发明人： Sergey Piletsky ,  Olena Piletska ,  Anthony Turner ,  Khalku Karim ,  Beining Chen

IPC分类号： H05B6/68

CPC分类号： C08G61/02 ,  C08G61/12 ,  C08G61/126

摘要： Monomers (e.g. thinphenes) are caused to polymerise by mixing them with an oxidising agent (and generally a solvent comprising water) and irradiating the mixture with light (visible or UV). Polymer properties can be varied by doping or chemical modification. Uses include sensor elements for assays and electrical components such as electrodes.

摘要翻译： 通过将单体（例如薄层）与氧化剂（通常是包含水的溶剂）混合并用光（可见或UV）照射混合物，使其聚合。 聚合物的性质可以通过掺杂或化学改性来改变。 用途包括用于测定的传感器元件和诸如电极的电气部件。

公开(公告)号：US20210349068A1

公开(公告)日：2021-11-11

申请号：US17274270

申请日：2019-09-03

申请人： Cranfield University

发明人： James Andrew Bremner ,  Thomas Kissinger ,  Elizabeth Jane Hodgkinson ,  Ralph Peter Tatam

IPC分类号： G01N33/00 ,  G01N21/45 ,  G01N21/39 ,  G01D5/353

摘要： An interferometric fluid sensing system is provided. The system comprises: a laser; a plurality of first fibre portions arranged to receive laser light from the laser, wherein each of the first fibre portions comprises a void and an opening to allow fluid from the environment around the corresponding first fibre portion to enter the void, wherein the first fibre portions are configured such that the laser light received by each first fibre portion passes through the corresponding void; a second fibre portion configured to provide a reference arm for the interferometric fluid sensing system; and a detector arranged to receive light from the first and second fibre portions, wherein the system is configured such that the laser light that passes through the void of each first fibre portion is caused to interfere with the light passing through the second fibre portion at or before reaching the detector, wherein each of the first fibre portions is arranged such that that light passing through the void of each first fibre portion travels from the laser to the detector over a different path length from the light passing through the voids of the other first fibre portions, wherein the system is configured such that the wavelength of light provided by the laser varies with time according to a modulated function, the modulated function comprising a first function, which varies through a range of wavelengths, modulated by a second, cyclical carrier function. An interferometric fluid detection method is also provided.

公开(公告)号：US10809217B2

公开(公告)日：2020-10-20

申请号：US16073658

申请日：2017-01-26

申请人： CORROSION RADAR LTD

发明人： Prafull Sharma ,  Hoi Yeung

IPC分类号： G01N27/20 ,  G01N17/00

摘要： A system (1) for detecting and locating corrosion on the outer surface of a metal body (2). The system includes an extended electromagnetic waveguide (6) arranged adjacent to the outer surface of the metal body. The electromagnetic waveguide includes a sacrificial component that experiences substantially the same environment as the outer surface of the metal body. The system also includes a waveform generator (10) arranged to be connected to the waveguide and to inject an electromagnetic waveform into the waveguide. The system also includes a waveform analyser (12) connected to the waveguide. The waveform analyser is arranged to receive a reflected portion of the injected electromagnetic waveform from the waveguide. The reflected portion of the injected electromagnetic waveform is used by the waveform analyser to determine the location of corrosion of the sacrificial component of the waveguide.