公开(公告)号：US20230037926A1

公开(公告)日：2023-02-09

申请号：US17790023

申请日：2020-12-28

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Pranava SINHA ,  William A. SMITH ,  Stephan WEBER

IPC分类号： A61M60/148 ,  A61M60/35 ,  A61M60/422 ,  A61M60/806 ,  A61M60/824 ,  A61M60/827 ,  A61M60/237

摘要： The circulation assist devices disclosed herein can be used, for example, in methods of decreasing venous pressure in the Fontan circulation. The devices can include an inlet, an outlet, a stator, a rotor, and an impeller driven by rotation of the rotor. In some embodiments, the impeller blade (or blades) can at least partially define a central lumen extending through the device. The device can be coupled to the inferior vena cava and the pulmonary artery. Rotating the impeller blade(s) increases blood velocity through the lumen and causes the outlet pressure to be higher than the inlet pressure. The impeller can be configured such that, when it is stationary, the forward static pressure drop between the inlet and the outlet is minimized. That is, the forward static pressure drop of the device approximates the pressure drop between the inferior vena cava and central pulmonary artery of the unassisted Fontan circulation.

公开(公告)号：US20220185909A1

公开(公告)日：2022-06-16

申请号：US17552862

申请日：2021-12-16

申请人： CHILDREN'S NATIONAL MEDICAL CENTER ,  THE GEORGE WASHINGTON UNIVERSITY ,  UNIVERSITAT DES SAARLANDES

发明人： Eric YVON ,  Catherine BOLLARD ,  Stacey VAN PELT ,  Scott RASKIN ,  Gerhard HELD ,  Christine STURM ,  Michael PFREUNDSCHUH

IPC分类号： C07K16/30 ,  C07K14/47

摘要： Disclosed are Synovial Sarcoma X breakpoint 2 binding molecules and methods for their use in the detection and treatment of cancer.

公开(公告)号：US11320441B2

公开(公告)日：2022-05-03

申请号：US15580047

申请日：2016-06-10

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Robert J. Freishtat ,  Evan Nadler ,  Monica Hubal ,  Sarah Ferrante

IPC分类号： G01N33/68 ,  G01N33/566 ,  G01N33/50 ,  G01N33/92 ,  C12Q1/6883

摘要： The invention relates to isolation of adipocyte-derived exosomes from a biological sample, as well as methods, compositions and kits for detecting an obesity-related disorder, for detecting risk of having an obesity-related disorder, for screening or identifying a therapy for an obesity-related disorder, for screening or identifying a therapeutic agent for an obesity-related disorder, and for treating or preventing an obesity-related disorder.

公开(公告)号：US20220098278A1

公开(公告)日：2022-03-31

申请号：US17490505

申请日：2021-09-30

申请人： Oncolmmune, Inc. ,  Children's National Medical Center

发明人： Yang Liu ,  Pan Zheng ,  Martin Devenport ,  Ning Li

IPC分类号： C07K14/705 ,  A61P25/00

摘要： The present invention relates to compositions and their use in methods of protecting and maintaining oligodendrocytes, and of treating demyelinating disorders

公开(公告)号：US20220064598A1

公开(公告)日：2022-03-03

申请号：US17421337

申请日：2020-01-07

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine Mary Bollard ,  Conrad Russell Y. Cruz ,  Patrick Hanley

IPC分类号： C12N5/0783 ,  A61K39/00 ,  A61P35/02

摘要： The disclosure provides T-cell compositions, therapies and processes of manufacture that are tailored to the specific antigenic expression of a subjects' tumor and allowing for changes in expression over time based on either pressure from antineoplastic therapy or natural heterogeneous selection. The disclosure also extends to methods of manufacturing such T-cell compositions and the generation of single antigen T-cell banks from healthy donors to provide an improved personalized T-cell therapy.

公开(公告)号：US11135028B2

公开(公告)日：2021-10-05

申请号：US15771689

申请日：2016-10-31

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Peter C. Kim ,  Justin D. Opfermann ,  Axel Krieger

IPC分类号： A61B34/37 ,  B25J9/14 ,  B25J15/10 ,  B25J15/12 ,  A61B17/02 ,  A61B17/28 ,  A61B34/00 ,  A61B90/00 ,  A61B17/29 ,  A61B17/32 ,  A61B17/00 ,  A61B1/313

摘要： A method is provided for making an appendage of a soft surgical tool, including: receiving a set of mechanical constraints for a surgical procedure; calculating a set of articulation states based on the set of mechanical constraints; generating a plurality of print commands for printing an appendage configured to form the set of articulation states based on the calculation; and printing an appendage based on the plurality of print commands. Multiple printed appendages can be formed into an orienting assembly.

公开(公告)号：US20210290747A1

公开(公告)日：2021-09-23

申请号：US17050829

申请日：2019-04-26

申请人： Children's National Medical Center

发明人： Patrick Hanley ,  Michael Keller

IPC分类号： A61K39/04 ,  A61P31/06 ,  C12N5/0783

摘要： The present disclosure relates, at least in part, to mycobacterial polynucleotides and polypeptides, to fragments or variants thereof, to cells comprising the mycobacterial polynucleotides and polypeptides, to cells comprising the mycobacterial polynucleotides and polypeptides, that are engineered to expand T-cells ex vivo, and to methods of use thereof.

公开(公告)号：US20210282654A1

公开(公告)日：2021-09-16

申请号：US17255731

申请日：2019-06-28

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Jaepyeong CHA ,  Corey ZHENG ,  Lung Wai LAU

IPC分类号： A61B5/026 ,  A61B1/313 ,  A61B1/05 ,  A61B1/00 ,  A61B1/07 ,  A61B5/00

摘要： A visualization system, an apparatus, and a visualization method are provided. The visualization system includes a laparoscope, a camera operatively coupled to the laparoscope, a light source operatively coupled to an illumination port of the laparoscope, and processing circuitry. The light source is configured to output one or more light beams each at a predetermined frequency to illuminate a target area. The processing circuitry is configured to process imaging data from the laparoscope received by the camera to generate one or more images of the target area including at least one laser speckle contrast image. The laparoscope is configured to output the one or more light beams toward the target area at a distal end thereof and to collect reflected and/or scattered light from the target area via the distal end.

公开(公告)号：US20210277355A1

公开(公告)日：2021-09-09

申请号：US17331296

申请日：2021-05-26

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine BOLLARD ,  Conrad CRUZ ,  Patrick HANLEY

IPC分类号： C12N5/0783 ,  A61K39/295 ,  C07K14/535 ,  C07K14/075 ,  C07K14/54 ,  C07K14/55 ,  A61K39/00 ,  A61K35/17

摘要： Safe, rapid and efficient methods for producing virus-specific or other antigen-specific T-cells from cord blood and other samples containing naive immune cells.

公开(公告)号：US20210214458A1

公开(公告)日：2021-07-15

申请号：US17055248

申请日：2019-05-13

申请人： ONCOIMMUNE, INC. ,  CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Yang Liu ,  Pan Zheng ,  Rhonda Flores ,  Hung-Yen Chou ,  Zhihong Xue ,  Peiying Ye ,  Martin Devenport

IPC分类号： C07K16/28 ,  A61P35/00

摘要： Provided herein are anti-CD24 antibodies that selectively bind human CD24 expressed in cancer cells, but not human CD24 expressed in non-cancerous cells, and the use of such antibodies in cancer therapy.