公开(公告)号：US4315861A

公开(公告)日：1982-02-16

申请号：US246412

申请日：1981-03-23

申请人： Gyorgy Lugosi ,  Antal Simay ,  Janos Bodnar ,  Istvan Turcsan ,  Istvan Jelinek ,  Eva Somfai ,  Laszlo Simandi

发明人： Gyorgy Lugosi ,  Antal Simay ,  Janos Bodnar ,  Istvan Turcsan ,  Istvan Jelinek ,  Eva Somfai ,  Laszlo Simandi

IPC分类号： C07D307/86 ,  C07D317/10 ,  C07C125/067

CPC分类号： C07D307/86

摘要： A process is disclosed for preparing a carbamic acid phenyl ester of the formula (I) ##STR1## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, or aralkyl having 7 to 16 carbon atoms, wherein the aryl, cycloalkyl or aralkyl is unsubstituted or substituted by at least one alkyl group having 1 to 8 carbon atoms;R.sub.1 is hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, cyanomethyl, 1,3-dioxolan-2-yl, or carboalkoxyamino wherein the alkoxy group contains 1 to 4 carbon atoms;R.sub.2 is hydrogen, halogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; orR.sub.1 and R.sub.2 form together a carbocyclic ring or a heterocyclic ring fused to the phenyl ring wherein the carbocyclic ring of the heterocyclic ring is unsubstituted or substituted by at least one alkyl having 1 to 8 carbon atoms, which comprises acylating a phenol of the formula (II) ##STR2## with a compound of the formula (IV) ##STR3## in the presence of a base. The compounds obtained are valuable intermediates.

摘要翻译： 公开了制备式（I）的氨基甲酸苯酯的方法，其中R是具有1至8个碳原子的烷基，具有5或6个碳原子的芳基，环烷基或具有7至16个碳原子的芳烷基， 其中芳基，环烷基或芳烷基是未取代的或被至少一个具有1至8个碳原子的烷基取代; R1是氢，具有1至4个碳原子的烷基，具有1至4个碳原子的烷氧基，氰基甲基，1,3-二氧戊环-2-基或烷氧基氨基，其中烷氧基含有1至4个碳原子; R2是氢，卤素，具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基; 或者R 1和R 2一起形成稠合到苯环的碳环或杂环，其中杂环的碳环是未取代的或被至少一个具有1至8个碳原子的烷基取代，其包括酰化式 （II）的化合物与式（IV）的化合物在碱的存在下反应。 所得化合物是有价值的中间体。