公开(公告)号：US20140319364A1

公开(公告)日：2014-10-30

申请号：US14262194

申请日：2014-04-25

申请人： Commissariat A L'Energie Atomique et Aux Energies Alternatives (Former name: Commissariat A L'Energie Atomique

发明人： Charlotte ROBERT ,  Guillaume MONTEMONT ,  Veronique REBUFFEL

IPC分类号： G01T1/24

CPC分类号： G01T1/24 ,  G01T1/1647

摘要： A photonic radiation detection device includes a collimator, a detector, and localization means for determining information relative to the localization of a photon interaction with the detector material. In at least one previously selected acquisition configuration, a degree of pixelation in the detection plane is greater than 1 and a collimator-detector distance (C) is greater than one tenth of the septal height (h) of the collimator where the septal height is a maximum dimension of the collimator in a direction orthogonal to the frontal detection plane. In one instance, the septal wall thickness (e) is one of about 0.1 or less than about 0.1 of the channel width (w). In another instance, the collimator-detector distance is greater than h/(2(w/e−1)). A dimensioning method includes, for at least one given spatial frequency, calculating and comparing merit indicator values for different acquisition configurations of a structural model of the detection device.

摘要翻译： 光子辐射检测装置包括准直器，检测器和用于确定相对于与检测器材料的光子相互作用的定位的信息的定位装置。 在至少一个先前选择的采集配置中，检测平面中的像素度大于1，并且准直器 - 检测器距离（C）大于准直器的间隔高度（h）的十分之一，其中间隔高度为 准直仪在与正面检测平面正交的方向上的最大尺寸。 在一种情况下，隔壁厚度（e）是通道宽度（w）的约0.1或小于约0.1之一。 在另一个实例中，准直器 - 检测器距离大于h /（2（w / e-1）））。 对于至少一个给定的空间频率，尺寸标注方法包括计算和比较检测装置的结构模型的不同采集配置的优点指标值。

公开(公告)号：US11639893B2

公开(公告)日：2023-05-02

申请号：US17678714

申请日：2022-02-23

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Jean-Guillaume Coutard ,  Cedric Allier ,  Sebastien Becker ,  Mathieu Dupoy

IPC分类号： G01N21/35 ,  G01N21/3563 ,  G01N21/39 ,  G01N33/483

摘要： A device for observing a biological sample is provided, including: a light source to emit a light beam at a wavelength between 1 μm and 20 μm; an image sensor including pixels defining a detection plane; a holder to hold the sample between the source and the sensor at a distance from the plane smaller than 1 mm, such that the source is configured to illuminate an area of the sample larger than 1 mm2, no image-forming optics are placed between the sample and the sensor, and the sensor is configured to acquire an image corresponding to an area of the sample larger than 1 mm2 and representative of an absorption of the beam by the sample at the wavelength; and a processor to determine a map of an amount of analyte in the sample, based on the image acquired by the sensor, the analyte absorbing light at the wavelength.

公开(公告)号：US11634810B2

公开(公告)日：2023-04-25

申请号：US16337623

申请日：2017-09-28

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Frédéric Schuster ,  Fernando Lomello ,  Francis Maury ,  Alexandre Michau ,  Raphaël Boichot ,  Michel Pons

IPC分类号： C23C16/18 ,  C23C16/02 ,  C23C16/10 ,  C23C16/32 ,  C23C16/34 ,  C23C16/36 ,  C23C16/448 ,  C23C16/56 ,  G21C3/07 ,  G21C3/20

摘要： Process for manufacturing a nuclear component comprising i) a support containing a substrate based on a metal (1), the substrate (1) being coated or not coated with an interposed layer (3) positioned between the substrate (1) and at least one protective layer (2) and ii) the protective layer (2) composed of a protective material comprising chromium; the process comprising a step a) of vaporizing a mother solution followed by a step b) of depositing the protective layer (2) onto the support via a process of chemical vapor deposition of an organometallic compound by direct liquid injection (DLI-MOCVD).

公开(公告)号：US20230120975A1

公开(公告)日：2023-04-20

申请号：US17915676

申请日：2021-03-29

申请人： UNIVERSITE GRENOBLE ALPES ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Lara Marwa JOBEILI ,  Alexandre Gaston Mickaël LELLOUCH ,  Walid RACHIDI ,  Laurent Alexandre LANTIERI

IPC分类号： A61L24/00 ,  A61L24/10 ,  A61L27/38 ,  A61K35/33 ,  A61P17/02

摘要： A biomaterial including a resorbable porous matrix formed from a material including collagen, and exhibiting an inner volume and an outer surface. Advantageously, the biomaterial includes at least one type of living biological cells of a tissue, disposed in the inner volume and alternatively or complementarily on the surface of the porous matrix. The biomaterial forms a tissue substitute being close to a native tissue, in particular in terms of biological structure present in the tissue, and physiological functions.

公开(公告)号：US11631739B2

公开(公告)日：2023-04-18

申请号：US16681905

申请日：2019-11-13

申请人： Commissariat A L'Energie Atomique et aux Energies Alternatives

发明人： Fabrice Nemouchi ,  Antonio Lacerda Santos Neto ,  Francois Lefloch

IPC分类号： H01L29/08 ,  H01L21/28 ,  H01L21/324 ,  H01L21/8234 ,  H01L29/49

摘要： A method for producing a transistor includes producing on a substrate provided with a semiconductor surface layer in which an active area can be formed, a gate block arranged on the active area. Lateral protection areas are formed against lateral faces of the gate block. Source and drain regions based on a metal material-semiconductor material compound are formed on either side of the gate and in the continuation of a portion located facing the gate block. Insulating spacers are formed on either side of the gate resting on the regions based on a metal material-semiconductor material compound.

公开(公告)号：US11631646B2

公开(公告)日：2023-04-18

申请号：US17216828

申请日：2021-03-30

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Stefan Landis ,  Michaël May

IPC分类号： H01L23/00 ,  H01L21/768

摘要： A method for producing a plurality of chips each comprising an individualisation region, each chip comprising at least: a first and a second level of the electrical tracks, and an interconnections level comprising vias. The method includes producing on the dielectric layer covering the first level a mask having openings located in line with the electrical tracks and making the dielectric layer accessible. The method includes producing, in a region of the chip comprising the individualisation region, patterns conformed so that: first openings of the hard mask are not masked by the patterns, and second openings of the hard mask are masked by the patterns. The method includes producing via openings in the dielectric layer in line solely with the first openings. The method further includes filling in the via openings with an electrically conductive material, and producing the second level of the electrical tracks on the vias.

公开(公告)号：US20230115626A1

公开(公告)日：2023-04-13

申请号：US17938783

申请日：2022-10-07

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Jean-Philippe COLONNA ,  Jean BRUN ,  Sami OUKASSI

IPC分类号： H01M10/0585 ,  H01M10/0562 ,  H01M50/562

摘要： A battery includes, stacked successively above a first face of a support, in a stacking direction, at least a cathode including a lower face, an upper face and a side wall directed in the stacking direction from the lower face to the upper face, a solid electrolyte, an anode, the battery including a coating portion surrounding, and in contact with, all of the side wall of the cathode, without covering the upper face of the cathode.

公开(公告)号：US11618001B2

公开(公告)日：2023-04-04

申请号：US16463907

申请日：2017-11-30

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Nathalie Herlin ,  Florent Boismain ,  John Alper

IPC分类号： B01J19/12 ,  B01J13/02 ,  C01B32/05 ,  B22F9/30 ,  B22F1/17

摘要： A device for synthesising core-shell nanoparticles by laser pyrolysis is provided. The device includes a reactor having a first chamber for the synthesis of the core, provided with an inlet for a core precursor, a second chamber for the synthesis of the shell, provided with an inlet for a shell precursor, and at least one communication channel between the two chambers to transmit the cores of the nanoparticles intended to be formed from the first chamber towards the second chamber. The device also includes an optical device to illuminate each of the two chambers, the device comprising at least one laser capable of emitting a laser beam intended to interact with the precursors to form the core and the shell. The device further includes at least a shell precursor inlet channel, one end of which is in the form of a distribution chamber surrounding the communication channel between the two chambers of the reactor, said distribution chamber being further provided, on its inner periphery, with at least one opening leading inside said communication channel.

公开(公告)号：US11613753B2

公开(公告)日：2023-03-28

申请号：US16758104

申请日：2018-10-26

申请人： LES LABORATOIRES SERVIER ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE GRENOBLE ALPES ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Annie Andrieux ,  Marie-José Moutin ,  Christophe Bosc ,  Chrystelle Aillaud ,  Leticia Peris ,  Philippe Delagrange

IPC分类号： A61P25/28 ,  C12N15/113 ,  C12Q1/37

摘要： Using chemical proteomics with a potent unique irreversible inhibitor, inventors found that major brain tubulin carboxypeptidase (TCP) is a complex of vasohibin-1 (VASH1) with the Small Vasohibin-Binding Protein (SVBP). VASH1 and its homologue vasohibin-2 (VASH2), when complexed with SVBP, exhibit robust and specific Tyr/Phe carboxypeptidase activity on microtubules. Accordingly inventors are the first to identify the enzymatic activity of vasohibin and vasohibin/SVBP complex. Knock down of vasohibins or SVBP in cultured neurons results in a marked reduction of tyrosinated α-tubulin levels and onset of severe differentiation defects. Furthermore, knock down of vasohibins disrupts neuronal migration in developing mouse neocortex. These results establish vasohibin/SVBP complexes as TCP enzymes. Accordingly, the present invention relates methods and pharmaceutical compositions for treating tubulin carboxypeptidases (TCP) associated diseases such as neurological disorders and cardiovascular diseases with an inhibitor of activity or expression of Vasohibin or Vasohibin/SVBP complex.

公开(公告)号：US11613520B2

公开(公告)日：2023-03-28

申请号：US16751856

申请日：2020-01-24

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Lionel Picard ,  Laurent Bernard ,  Sandrine Lyonnard ,  Hakima Mendil

IPC分类号： C07C309/47 ,  C07C307/02 ,  H01M10/052 ,  H01M10/0566 ,  H01M10/056 ,  C07C311/48 ,  C09K19/32 ,  C09K19/40 ,  H01M10/054

摘要： The present invention relates to thermotropic ionic liquid crystal molecules of general formula (I) With E1 and E2, which may be identical or different, representing, independently of one another, a linear, saturated and unsubstituted C10 to C14 hydrocarbon-based radical, Ax− representing a sulfonate anion or a sulfonylimide anion of formula —SO2—N−—SO2CyF2y+1 with y being an integer ranging from 0 to 2 and Cx+ a sodium, lithium or potassium ion, most particularly advantageous for their conductivity performance qualities as an electrolyte in particular for lithium batteries.