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公开(公告)号：US20220375551A1
公开(公告)日：2022-11-24
申请号：US17847057
申请日：2022-06-22
申请人： Cytel Inc.
发明人： Nitin Patel , Jaydeep Bhattacharyya , Albert M. Kim , Yannis Jemiai , Jay Kyle Wathen , Sagar Mehta , Christopher Michael Porayko
IPC分类号： G16H10/20 , G06F30/20 , G06Q10/06 , G06F30/12 , G16H40/20 , G16H50/70 , G06N20/00 , G06Q30/02 , G06F30/10 , G06N5/04
摘要： A method and system including identifying, via at least one processor, a user role; configuring, via the at least one processor, an interface for the user role, wherein configuring the interface includes determining an interface view for the user role; and displaying, via the at least one processor, the interface with the interface view.
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公开(公告)号：US20210241859A1
公开(公告)日：2021-08-05
申请号：US17163423
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method for determining trial designs is provided. The method includes obtaining simulation data for a set of trial designs. The simulation data includes performance parameters and performance parameter values associated with each design in the set of designs for a set of criteria; determining an optimality criteria for evaluating the trial designs; searching, within the set of trial designs, for globally optimum designs based on the optimality criteria; and recommending globally optimum designs.
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公开(公告)号：US20210240883A1
公开(公告)日：2021-08-05
申请号：US17163424
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, includes obtaining a criteria for a trial design study, determining permutations for designs in response to the criteria, and determining permutations for scenarios in response to the criteria. The method may further include generating combinations of the permutations for the designs and the permutations for the scenarios, simulating designs corresponding to the generated combinations, and determining performance of the simulated designs.
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公开(公告)号：US20210241866A1
公开(公告)日：2021-08-05
申请号：US17163438
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method for trial design includes presenting on a graphical interface, a set of cards, wherein each card in the set is representative of a different trial design from a set of trial designs. The method further includes: monitoring a first set of user interactions with the set of cards; determining a user preference for one or more values of one or more parameters of the set of trial designs from the first set of user interactions; and presenting on the graphical interface a new card that is representative of a trial design consistent with the determined user preference. The method may also include monitoring a second set of user interactions with the new card and refining the determined user preference based at least in part on the second set of user interactions with the new card.
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公开(公告)号：US20210241860A1
公开(公告)日：2021-08-05
申请号：US17163425
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method for determining trial designs is provided. The method includes receiving, via at least one processor, one or more trial design criteria and one or more scenarios corresponding to a set of trial designs, and generating, via the at least one processor, simulation data based at least in part on replicating each of the set of trial designs with the one or more trial design criteria and the one or more scenarios. The simulation data includes performance parameters and performance parameter values associated with each design in the set of designs for a set of criteria. The method further includes determining, via the at least one processor, an optimality criteria for evaluating the trial designs, searching, within the set of trial designs, via the at least one processor, for globally optimum designs based on the optimality criteria, and transmitting, via the at least one processor, globally optimum designs.
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公开(公告)号：US20210241144A1
公开(公告)日：2021-08-05
申请号：US17163427
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, includes obtaining trial design simulation results for a set of trial designs and determining a set of Pareto designs in the set of trial designs based at least in part on the trial design simulation results and one or more performance parameters. The method further includes determining a set of convex hull designs in the set of trial designs, determining a set of recommended designs based at least in part on the set of Pareto designs and the set of convex hull designs, and transmitting the set of recommended designs.
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7.发明授权Use of trans-sialidase and sialyltransferase for synthesis of sialyl.alpha.2.fwdarw.3.beta.galactosides 失效使用唾液酸酶和唾液酸转移酶合成唾液酸α2->3β半乳糖苷
公开(公告)号：US5409817A
公开(公告)日：1995-04-25
申请号：US57528
申请日：1993-05-04
申请人： Yukishige Ito , James C. Paulson
发明人： Yukishige Ito , James C. Paulson
CPC分类号： C12N9/1241 , C12N9/1081 , C12N9/2402 , C12P19/26 , C12Y302/01018
摘要： A single vessel cyclic synthesis process for preparation of a sialyl.alpha.2.fwdarw.3.beta.galactoside is disclosed. In accordance with this process, a sialyltransferase acceptor is sialylated in an aqueous reaction medium by an .alpha.(2,3)sialyl transferase and CMP-sialic acid to form a sialyl donor substrate and CMP. In the presence of the trans-sialidase of Trypanosoma crusi, that sialyl donor substrate provides a sialyl group for a trans-sialidase acceptor, thereby preparing the sialyl.alpha.2.fwdarw.3.beta.galactoside. The .alpha.(2,3)sialyltransferase acceptor is reformed upon trans-sialidation of the latter acceptor, and the sialyl donor substrate is reformed using the .alpha.(2,3)sialyltransferase and a CMP-sialic acid recycling system that combines CMP with sialic acid that is also present in the vessel. The K.sub.m /V.sub.max value for the .alpha.(2,3)sialyltransferase acceptor is less than one-tenth the value of K.sub.m /V.sub.max of the trans-sialidase acceptor for the .alpha.(2,3)sialyltransferase.
摘要翻译： 公开了用于制备唾液酸α2->3β半乳糖苷的单容器循环合成方法。 根据该方法，唾液酸转移酶受体通过α（2,3）唾液酸转移酶和CMP-唾液酸在水性反应介质中唾液酸化以形成唾液酸供体底物和CMP。 在克氏锥虫的唾液酸酶的存在下，唾液酸供体底物为唾液酸酶受体提供唾液酸基，从而制备唾液酸α2->3β半乳糖苷。 将α（2,3）唾液酸转移酶受体通过后一个受体的反式唾液酸化进行重组，并且使用α（2,3）唾液酸转移酶和将CMP与唾液酸组合的CMP-唾液酸回收系统重组唾液酸供体底物 这也存在于船上。 α（2,3）唾液酸转移酶受体的Km / Vmax值小于α（2,3）唾液酸转移酶的唾液酸酶受体的Km / Vmax值的十分之一。
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公开(公告)号：US20220374558A1
公开(公告)日：2022-11-24
申请号：US17847040
申请日：2022-06-22
申请人： Cytel Inc.
发明人： Nitin Patel , Jaydeep Bhattacharyya , Albert M. Kim , Yannis Jemiai , Jay Kyle Wathen , Sagar Mehta , Christopher Michael Porayko
摘要： A method for trial design analysis that includes receiving, for each trial design of a plurality of trial designs, a set of simulated performance criteria for a set of trial designs, and visualizing, on a graph, values for a first simulated performance criteria and a second simulated performance criteria from the set of simulated performance criteria for each trial design using a location of points on the graph corresponding to the set of trial designs. The method further includes identifying optimal designs based on an optimality criteria using the set of the simulated performance criteria, and determining a tradeoff metric for the first simulated performance criteria and the second simulated performance criteria. The method further includes displaying, the tradeoff metric as a set of lines on the graph, wherein a slope of the lines corresponds to a value of the tradeoff metric.
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公开(公告)号：US20210241864A1
公开(公告)日：2021-08-05
申请号：US17163436
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method for trial design with simulated annealing includes obtaining, via at least one processor of a trial design platform, initial trial design simulation results data for a set of trial designs. The method may further include identifying an initial design from the design simulation results data, predicting, performance data of designs for variations of parameters corresponding to the set of trial designs, and identifying a new design for simulation by varying parameters of the initial simulated design based on the predicting. The method may also include simulating the new design, determining performance data of the new design, and identifying a second new design for simulation by varying parameters of the new design based on the simulated performance of the new design.
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公开(公告)号：US20210241863A1
公开(公告)日：2021-08-05
申请号：US17163433
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, determining, via at least one processor, a plurality of possible sites for recruiting patients from for a trial and determining, via the at least one processor and for each of one or more subgroupings of the plurality of possible sites, a predicted available resources value. The method may further include determining, via the at least one processor, which subgrouping of the plurality of possible sites has a predicted available resources value that globally optimizes a desired site resource criteria.
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