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    APPARATUS AND METHOD FOR GATING DELIVERY OF RADIATION BASED ON CAPACITIVE MONITORING OF RESPIRATORY MOTION
    1.
    发明申请
    APPARATUS AND METHOD FOR GATING DELIVERY OF RADIATION BASED ON CAPACITIVE MONITORING OF RESPIRATORY MOTION 有权

    公开(公告)号：US20220008751A1

    公开(公告)日：2022-01-13

    申请号：US17296758

    申请日：2019-12-06

    申请人： DALHOUSIE UNIVERSITY

    发明人： Parisa SADEGHI ,  James Robar

    IPC分类号： A61N5/10

    摘要： An apparatus for gating delivery of radiation by a radiation delivery system to a patient is described. The apparatus includes at least one electrode positionable adjacent to but not touching a patient, at least one capacitance sensor electrically connected to the at least one electrode and configured to monitor a capacitance of the at least one electrode and generate an output signal indicative of the capacitance, and at least one processor configured to receive and process the output signal, determine a computed measure of amplitude and/or phase of respiration of the patient, and generate a gating signal for enabling or inhibiting delivery of radiation by the radiation delivery system based on the determined measure of amplitude and/or phase of respiration of the patient.

    Detection and monitoring of changes in mineralized tissues or calcified deposits by optical coherence tomography and Raman spectroscopy
    9.
    发明授权
    Detection and monitoring of changes in mineralized tissues or calcified deposits by optical coherence tomography and Raman spectroscopy 有权
    通过光学相干断层扫描和拉曼光谱法检测和监测矿化组织或钙化沉积物的变化

    公开(公告)号：US07796243B2

    公开(公告)日：2010-09-14

    申请号：US11148422

    申请日：2005-06-09

    申请人： Lin-P'ing Choo-Smith ,  Alex C. T. Ko ,  Mark Hewko ,  Lorenzo Leonardi ,  Blaine Cleghorn ,  Cecilia Dong

    发明人： Lin-P'ing Choo-Smith ,  Alex C. T. Ko ,  Mark Hewko ,  Lorenzo Leonardi ,  Blaine Cleghorn ,  Cecilia Dong

    IPC分类号： G01N21/00

    CPC分类号： A61B5/0066 ,  A61B5/0088

    摘要： Early dental caries detection is carried out by a method that combines optical coherence tomography (OCT) and Raman spectroscopy to provide morphological information and biochemical specificity for detecting and characterizing incipient carious lesions found in extracted human teeth. OCT imaging of tooth samples demonstrated increased light back-scattering intensity at sites of carious lesions as compared to the sound enamel. Raman microspectroscopy and fibre-optic based Raman spectroscopy are used to characterize the caries further by detecting demineralization-induced alterations of enamel crystallite morphology and/or orientation. OCT imaging is useful for screening carious sites and determining lesion depth, with Raman spectroscopy providing biochemical confirmation of caries. The combination is incorporated into a common probe operable without movement to scan the tooth surface and to provide an output for the dentist.

    摘要翻译： 早期龋齿检测是通过光学相干断层扫描（OCT）和拉曼光谱相结合的方法进行的，以提供形态信息和生物化学特异性，用于检测和表征提取的人牙齿中发现的初期龋病。 与搪瓷相比，牙齿样品的OCT成像显示龋损灶部位的光背散射强度增加。 拉曼显微光谱和基于光纤的拉曼光谱法用于通过检测软化诱导的釉质微晶形态和/或取向的改变来进一步表征龋齿。 OCT成像可用于筛选龋齿位点和确定病变深度，拉曼光谱提供龋齿的生化确认。 该组合被并入通用探针中，其可操作而不移动以扫描牙齿表面并为牙医提供输出。

    Uses for pentoxifylline or functional derivatives/metabolites thereof
    10.
    发明授权
    Uses for pentoxifylline or functional derivatives/metabolites thereof 失效
    用于己酮可可碱或其功能衍生物/代谢物

    公开(公告)号：US5985592A

    公开(公告)日：1999-11-16

    申请号：US870096

    申请日：1997-06-05

    申请人： Theresa C. Peterson

    发明人： Theresa C. Peterson

    IPC分类号： A61K31/00 ,  A61K31/522 ,  A61K38/00 ,  A61K45/06 ,  C12N15/113 ,  G01N33/68 ,  C12Q1/02 ,  C12Q1/00 ,  C12Q1/50 ,  G01N33/53

    CPC分类号： C12N15/1135 ,  A61K31/00 ,  A61K31/522 ,  A61K45/06 ,  G01N33/6887 ,  A61K38/00 ,  C12N2310/315 ,  G01N2333/49 ,  G01N2333/52 ,  G01N2333/78 ,  G01N2500/00 ,  Y10S435/975

    摘要： In accordance with the present invention, it has been discovered that monocyte conditioned medium (MCM) obtained from patients with liver disease stimulates the proliferation of fibroblasts. Platelet derived growth factor (PDGF) has also been found to stimulate fibroproliferation of fibroblasts, and to be at least partially responsible for the fibroproliferative effect of the MCM. Further in accordance with the present invention, the effect of MCM and PDGF on the expression of c-fos and c-jun has been investigated, because c-fos and c-jun form AP-1 complexes which can stimulate genes involved in proliferation. It has recently been reported that pentoxifylline inhibits platelet derived growth factor-stimulated proliferation. The mechanism of this action of pentoxifylline is unclear. Thus, in the course of the work undertaken as part of the present invention, studies were conducted to determine whether pentoxifylline altered the expression of c-fos and c-jun. While PDGF was found to induce the expression of both c-fos and c-jun, pentoxifylline was found to effectively reduce the effect of PDGF-induced c-jun gene expression, without altering c-fos gene expression. These results suggest that pentoxifylline inhibits PDGF stimulated proliferation by decreasing c-jun expression. These results further suggest a variety of diseases and/or conditions which may also be successfully treated with pentoxifylline.

    摘要翻译： 根据本发明，已经发现从肝病患者获得的单核细胞条件培养基（MCM）刺激成纤维细胞的增殖。 还发现血小板衍生生长因子（PDGF）刺激成纤维细胞的纤维增生，并且至少部分地负责MCM的纤维增生作用。 此外，根据本发明，已经研究了MCM和PDGF对c-fos和c-jun表达的影响，因为c-fos和c-jun形成可以刺激涉及增殖的基因的AP-1复合物。 最近报道己酮可可碱抑制血小板衍生生长因子刺激的增殖。 己酮可可碱的这种作用的机制尚不清楚。 因此，在作为本发明的一部分进行的工作中，进行了研究以确定己酮可可碱是否改变了c-fos和c-jun的表达。 当发现PDGF诱导c-fos和c-jun两者的表达时，发现己酮可可碱有效地降低PDGF诱导的c-jun基因表达的作用，而不改变c-fos基因表达。 这些结果表明己酮可可碱通过降低c-jun表达来抑制PDGF刺激的增殖。 这些结果进一步表明也可以用己酮可可碱成功治疗的各种疾病和/或病症。