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公开(公告)号：US12128158B2
公开(公告)日：2024-10-29
申请号：US18108038
申请日：2023-02-10
申请人： DSM IP Assets B.V.
发明人： Noel L. Davison , Henricus Johannes Arts , Aylvin Jorge Angelo Athanasius Dias , Anne Marie Persson , Ruud Jozef Regina Wilhelmus Peters
IPC分类号： A61L31/08 , A61L17/04 , A61L17/14 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04
CPC分类号： A61L31/086 , A61L17/04 , A61L17/145 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04 , A61L2420/02 , A61L2430/02 , A61L2430/38
摘要： The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.
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公开(公告)号：US20240352236A1
公开(公告)日：2024-10-24
申请号：US18682570
申请日：2023-08-09
发明人： Rudan YA , Fei ZHANG , Zhoupin LIU , Jie ZHAO , Chienkuo YUAN
CPC分类号： C08L5/00 , B01J13/046 , C08L2205/02
摘要： The present invention relates to a compound thickener comprising rhamsan gum and gellan gum. In the compound thickener, rhamsan gum accounts for 50%-95% of the total weight of rhamsan gum and gellan gum. The combination of rhamsan gum and gellan gum in the compound thickener produces a synergistic effect, and its viscosity is remarkably improved. The compound thickener can be applied to products such as foods, beverages, pharmaceutical products, and personal care products, and when the compound thickener is applied as a gelling agent in soft capsule shells, the shell strength and the shell elasticity are better.
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公开(公告)号：US20240350390A1
公开(公告)日：2024-10-24
申请号：US18683029
申请日：2022-08-23
申请人： DSM IP ASSETS B.V.
CPC分类号： A61K8/608 , A61K8/442 , A61Q19/005 , A61Q19/10 , A61K2800/30
摘要： The present invention relates to sulfate-free cleansing compositions comprising at least one zwitterionic surfactant and at least one human milk oligosaccharide as well as to a method of increasing the foaming properties of cleansing compositions comprising at least one surfactant by incorporation of one or more human milk oligosaccharides into said cleansing composition.
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公开(公告)号：US20240342095A1
公开(公告)日：2024-10-17
申请号：US18753538
申请日：2024-06-25
申请人： DSM IP Assets B.V.
CPC分类号： A61K9/2063 , A61K9/2009 , A61K9/2031 , A61K9/2095 , A61K9/288 , A61K31/04
摘要： Compositions are formed of a compressed mixture which includes a powderous formulation of a carrier and 3-nitrooxypropanol or derivatives thereof as an active ingredient, and a gluten. The composition remains intact in water after 24 hours.
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5.发明公开公开(公告)号：US20240327886A1
公开(公告)日：2024-10-03
申请号：US18561233
申请日：2022-05-17
申请人： DSM IP Assets B.V.
发明人： Manos PAPADAKIS , Ted JOHANSON , Peter BECKER
CPC分类号： C12P19/04 , C07K14/245 , C12N1/20 , C12N9/1051 , C12N15/52 , C12P19/18 , C12R2001/19 , C12Y204/01062 , C12Y204/01069 , C12Y204/01222
摘要： This invention relates to a method of producing mixtures of various human milk oligosaccharides (HMOs) with unique HMO blend profiles, consisting predominantly of LNFP-I and LNT and of other HMOs in less significant amounts. The less abundant HMOs might be 2′-FL, LNT-II or DFL. The strategies for achieving specific HMO blends include strain engineering and fermentation methods.
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公开(公告)号：US20240327777A1
公开(公告)日：2024-10-03
申请号：US18709000
申请日：2022-11-10
申请人： DSM IP ASSETS B.V.
发明人： Natalia CHRAPKOVA , Peter BECKER , Ted JOHANSON , Mikael JANSEN
摘要： A feed control system and related methods for a heterologous product, such as a human milk oligosaccharide, fermentation system are disclosed. The feed control system comprises a feed controller. The feed controller comprises a processor and an interface. The processor is configured to obtain a biomass content in a fermentation broth. The processor is configured to determine a carbon input parameter based on the biomass content. The processor is configured to control a carbon input to the fermentation broth according to the carbon input parameter.
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公开(公告)号：US12104139B2
公开(公告)日：2024-10-01
申请号：US16563260
申请日：2019-09-06
申请人： DSM IP ASSETS B.V.
IPC分类号： C11B1/02 , C07C51/42 , C07C51/487 , C11B3/00
CPC分类号： C11B1/02 , C07C51/42 , C07C51/487 , C11B1/025 , C11B3/001 , C07C51/487 , C07C57/03 , C07C51/42 , C07C57/03
摘要： Disclosed herein are processes for obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PUFAs) from one or more microbial cells by lysing the cells to form a lysed cell composition, treating the lysed cell composition to form an oil-containing emulsion and then recovering the oil from the oil-containing emulsion. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.
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8.发明授权公开(公告)号：US12076463B2
公开(公告)日：2024-09-03
申请号：US17849893
申请日：2022-06-27
CPC分类号： A61L27/46 , A61L27/446 , A61L27/54 , A61L27/56 , A61L2420/02 , A61L2420/04 , A61L2430/02 , C08L75/04
摘要： The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 μm; providing a dispersion of bioactive ceramic particles of particle size at most 10 μm in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent.
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9.发明公开公开(公告)号：US20240240137A1
公开(公告)日：2024-07-18
申请号：US18419326
申请日：2024-01-22
申请人： DSM IP Assets B.V.
IPC分类号： C12N1/20 , A23C9/123 , A23L33/135 , C07K14/195 , C07K14/315 , C12R1/46
CPC分类号： C12N1/20 , A23C9/1236 , A23L33/135 , C07K14/195 , C07K14/315 , C12N1/205 , A23V2400/131 , A23V2400/157 , A23V2400/249 , C12R2001/46
摘要： The present invention relates to the field of microbiology, specifically the field of production of a dairy food product using fermentation and the field of gene transfer by conjugation.
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公开(公告)号：US20240239839A1
公开(公告)日：2024-07-18
申请号：US18559242
申请日：2022-05-03
申请人： DSM IP Assets B.V.
摘要： The present invention relates to purification of a tripeptide of formula (I). By using said method, the tripeptide of formula (I) is obtained in a very pure form and due to this effect the purified tripeptide can be used in a variety of cosmetic and pharmaceutic compositions which are not accessible for the respective unpurified tripeptide.
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