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公开(公告)号：US08968780B2
公开(公告)日：2015-03-03
申请号：US13582162
申请日：2011-03-01
IPC分类号： A61K9/28 , A61K9/16 , A61K31/197
CPC分类号： A61K9/1623 , A61K9/4858 , A61K31/195 , A61K31/197
摘要： The invention relates to stabilized pharmaceutical composition comprising pregabalin and a disaccharide or higher polyol as stabilizer and optionally a conventional pharmaceutically acceptable carrier. The stabilized pharmaceutical composition according to the invention is useful in the treatment of a number of diseases such as epilepsy, Alzheimer's disease or Parkinson's disease.
摘要翻译： 本发明涉及稳定的药物组合物，其包含普瑞巴林和二糖或更高级多元醇作为稳定剂和任选的常规药学上可接受的载体。 根据本发明的稳定化药物组合物可用于治疗许多疾病如癫痫，阿尔茨海默病或帕金森病。
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公开(公告)号：US08507513B2
公开(公告)日：2013-08-13
申请号：US13143943
申请日：2010-01-15
申请人： Gyoergyi Kovanyine Lax , Eva Sipos , Jozsef Barkoczy , Balazs Volk , Gyula Simig , Ferenc Bartha , Gyoergy Ruzsics , Adrienn Karasz , Imre Kiraly , Kalman Nagy
发明人： Gyoergyi Kovanyine Lax , Eva Sipos , Jozsef Barkoczy , Balazs Volk , Gyula Simig , Ferenc Bartha , Gyoergy Ruzsics , Adrienn Karasz , Imre Kiraly , Kalman Nagy
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/42
摘要： The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methanesulphonyl-methyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated.
摘要翻译： 本发明涉及一种制备瑞舒伐他汀[7- [4-（4-氟苯基）-6-异丙基-2-（甲磺酰基 - 甲基 - 氨基） - 嘧啶-5-基] - （3R，51S ） - 二羟基 - 庚-6-烯酸]与二价阳离子形成的盐，优选与钙或锌离子形成，其特征在于，瑞舒伐他汀叔丁基铵盐与适当的二价阳离子，优选与钙 或与水不混溶或与水混溶的有机溶剂和水的混合物中的锌离子与形成的盐分离。
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