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公开(公告)号：US11320438B2
公开(公告)日：2022-05-03
申请号：US15772030
申请日：2016-10-31
发明人： Sasa Koncarevic , Karsten Kuhn , Peter Schulz-Knappe , Ian Hugo Pike , Christiane Opitz , Michael Platten
IPC分类号： G01N33/68 , G01N33/532
摘要： Tryptophan degradation is a key metabolic pathway controlling immune reactions and evidence suggests that during cancer progression generation of tryptophan metabolites may be fundamental for immune escape promoting the malignant phenotype of cancer cells in an autocrine fashion. The present invention relates to methods of measuring mass tag labelled tryptophan and metabolites thereof and methods using the labelled molecules for monitoring in a subject the effectiveness of a treatment and of disease recurrence after treatment, for stratifying patients and for diagnosing suppression of an immune response in a subject.
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公开(公告)号：US10527629B2
公开(公告)日：2020-01-07
申请号：US15318247
申请日：2015-06-12
IPC分类号： G01N33/00 , G01N33/68 , C12Q1/6872 , C07B59/00 , C07K5/02
摘要： The present invention relates to a set of two or more mass labels. Each mass label comprises: X-L-M-Re; X is a reporter moiety having exact mass; L is a bond cleavable by collision in a mass spectrometer; M is a mass modifier; Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte. Each mass label in the set has the same integer mass; wherein the set comprises two or more subsets of mass labels, each subset comprising one or more mass labels; wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets; each mass label is distinguishable by mass spectrometry.
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公开(公告)号：US20180364244A1
公开(公告)日：2018-12-20
申请号：US16061177
申请日：2016-12-09
IPC分类号： G01N33/58 , C07D207/46 , G01N33/532 , G01N33/68
摘要： The present invention relates to a set of two or more mass labels, wherein each mass label comprises the formula: X-L-M-Re wherein X is a reporter moiety having an exact mass, L is a bond cleavable by collision in a mass spectrometer, M is a mass modifier, and Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte, wherein each mass label in the set has an integer mass, wherein each mass label in the set has the same integer mass, and wherein the set comprises two or more subsets of mass labels, each subset comprising one, two or more mass labels, and wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets, and wherein each mass label is distinguishable by mass spectrometry.
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公开(公告)号：US09023656B2
公开(公告)日：2015-05-05
申请号：US11996910
申请日：2006-07-26
申请人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
发明人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
IPC分类号： G01N33/68 , C07D401/12 , C07D239/04 , C07D403/12 , C07D207/404 , C07K5/078
CPC分类号： C07D403/12 , C07D207/404 , C07D401/12 , C07K5/06139 , G01N33/6848 , G01N2458/00 , Y10T436/24
摘要： A mass label for labelling and detecting a biological molecule by mass spectroscopy, which label comprises the following structure: X-L-M wherein X is a mass marker moiety comprising the following group: formula (I), wherein the cyclic unit is aromatic or aliphatic and comprises from 0-3 double bonds independently between any two adjacent atoms; each Z is independently N, N(R1), C(R1), CO, CO(R1), C(R1)2, O or S; X is N, C or C(R1); each R1 is independently H, a substituted or unsubstituted straight or branched C1-C6 alkyl group, a substituted or unsubstituted aliphatic cyclic group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group; and y is an integer from 0-10, L is a cleavable linker comprising an amide bond and M is a mass normalization moiety.
摘要翻译： 用于通过质谱法标记和检测生物分子的质量标签，该标签包含以下结构：XLM，其中X是包含以下基团的质量标记物部分：式（I），其中所述环状单元是芳族或脂族的，并且包含 0-3双键独立地在任意两个相邻的原子之间; 每个Z独立为N，N（R1），C（R1），CO，CO（R1），C（R1）2，O或S; X为N，C或C（R1）; 每个R 1独立地为H，取代或未取代的直链或支链C 1 -C 6烷基，取代或未取代的脂族环基，取代或未取代的芳基或取代或未取代的杂环基; y是0-10的整数，L是包含酰胺键的可切割连接物，M是质量归一化部分。
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公开(公告)号：US20150065392A1
公开(公告)日：2015-03-05
申请号：US14485994
申请日：2014-09-15
发明人： Christian Baumann , Stefan Kienle , Karsten Kuhn , Harald Legner
IPC分类号： G01N33/74 , C07D211/14 , G01N33/58 , C07D401/12
CPC分类号： G01N33/743 , C07B59/002 , C07D211/14 , C07D401/12 , G01N33/58 , G01N2458/15 , G01N2560/00 , Y10T436/196666 , Y10T436/200833 , Y10T436/24
摘要： A reactive mass label for labelling a biological molecule for detection by mass spectrometry includes the following structure: X-L-M-S-Re, wherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, and S is a mass series modifying group including the following group: wherein J is C═O, K is NH, and n is 2 or J and K are both CH2 and n is 1, m is at least 1; and Re is a reactive functionality for attaching the reactive mass label to a biological molecule.
摘要翻译： 用于通过质谱法标记用于检测的生物分子的反应性质量标签包括以下结构：XLMS-Re，其中X是质量标记物部分，L是可切割接头，M是质量归一化部分，S是质量序列 包括以下基团的改性基团：其中J为C = O，K为NH，n为2或J和K均为CH 2且n为1，m为至少1; 并且Re是用于将反应性质量标签附着到生物分子的反应性官能团。
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6.发明申请CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES 审中-公开CASEIN KINASE 1Delta（CK 1delta）抑制剂及其在治疗神经源性疾病如TAUOPATHIES中的应用公开(公告)号：US20140031547A1
公开(公告)日：2014-01-30
申请号：US13993288
申请日：2011-12-14
IPC分类号： C07D401/12
CPC分类号： A61K31/517 , A61K31/397 , A61K31/4045 , A61K31/4192 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/55 , C07D209/42 , C07D277/68 , C07D401/04 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/12 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D495/14
摘要： The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
摘要翻译： 本发明涉及包含酪蛋白激酶1δ（CK1delta）的药物组合物以及所述抑制剂在治疗神经变性疾病如阿尔茨海默病中的用途。
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公开(公告)号：US07767401B2
公开(公告)日：2010-08-03
申请号：US10568093
申请日：2004-08-16
申请人： Pierre Lescuyer , Denis Francois Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
发明人： Pierre Lescuyer , Denis Francois Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
IPC分类号： G01N33/00 , G01N33/543
CPC分类号： G01N33/6893 , G01N2333/4709 , G01N2333/775 , G01N2333/8128 , G01N2800/2871
摘要： Stroke is diagnosed in a subject by determining the concentration of at least one polypeptide selected from Apo C-III, Serum Amyloid A, Apo C-I, Antithrombin III fragment and Apo A-I in a sample of body fluid taken from the subject.
摘要翻译： 通过从取自受试者的体液样品中测定至少一种选自Apo C-III，血清淀粉样蛋白A，Apo C-I，抗凝血酶III片段和Apo A-I的多肽的浓度，在受试者中诊断中风。
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公开(公告)号：US07294456B2
公开(公告)日：2007-11-13
申请号：US10221666
申请日：2001-03-14
IPC分类号： C12Q1/00
CPC分类号： C07H21/00 , C07K1/1077 , C12Q1/6872 , C40B40/00 , G01N33/6803 , G01N2458/15 , Y10T436/13
摘要： Provided herein are sets of mass labels. Each mass label in a set includes 1) a mass marker moiety; 2) a mass normalisation moiety; and 3) a cleavable linker connecting the mass marker moiety to the mass normalisation moiety. Each mass marker moiety is characterised as having a mass different from that of all other mass marker moieties in the set as determined by mass spectrometry. Further, each mass normalisation moiety ensures that each mass label in the set has substantially the same mass as determined by mass spectrometry.
摘要翻译： 本文提供了一组质量标签。 一组中的每个质量标签包括1）质量标记部分; 2）质量归一化部分; 和3）将质量标记部分连接到质量标准化部分的可切割的连接体。 每个质量标记物部分的特征在于质量不同于通过质谱法测定的组中所有其它质量标记物部分的质量。 此外，每个质量归一化部分确保组中的每个质量标签具有与通过质谱法测定的质量基本相同的质量。
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公开(公告)号：US20180362416A1
公开(公告)日：2018-12-20
申请号：US16061136
申请日：2016-12-09
IPC分类号： C07B59/00 , C07D403/12 , G01N33/58
摘要： The present invention relates to a set of two or more mass labels, wherein each mass label comprises the formula: X-L-M-Re wherein X is a reporter moiety having an exact mass, L is a bond cleavable by collision in a mass spectrometer, M is a mass modifier, and Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte, wherein each mass label in the set has an integer mass, wherein each mass label in the set has the same integer mass, and wherein the set comprises two or more subsets of mass labels, each subset comprising one, two or more mass labels, and wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets, and wherein each mass label is distinguishable by mass spectrometry.
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公开(公告)号：US20180246118A1
公开(公告)日：2018-08-30
申请号：US15772030
申请日：2016-10-31
发明人： Sasa Koncarevic , Karsten Kuhn , Peter Schulz-Knappe , Ian Hugo Pike , Christiane Opitz , Michael Platten
IPC分类号： G01N33/68 , G01N33/532
CPC分类号： G01N33/6848 , G01N33/532 , G01N2458/15
摘要： Tryptophan degradation is a key metabolic pathway controlling immune reactions and evidence suggests that during cancer progression generation of tryptophan metabolites may be fundamental for immune escape promoting the malignant phenotype of cancer cells in an autocrine fashion. The present invention relates to methods of measuring mass tag labelled tryptophan and metabolites thereof and methods using the labelled molecules for monitoring in a subject the effectiveness of a treatment and of disease recurrence after treatment, for stratifying patients and for diagnosing suppression of an immune response in a subject.
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