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公开(公告)号：US11020347B2
公开(公告)日：2021-06-01
申请号：US15763685
申请日：2016-09-27
摘要： A self-foaming composition is described that includes trifarotene, for a no-rinse topical application and for application to the skin. The composition can include: at least one intermediate composition B including a gas-generating agent; at least one intermediate composition A including an agent for activating the gas-generating agent; and trifarotene or one of the pharmaceutically acceptable salts thereof being present in at least one of the intermediate compositions A and B. The composition is particularly intended for the treatment of acne. Also described is a kit or a single container including a plurality of compartments including such a composition.
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公开(公告)号：US10987307B2
公开(公告)日：2021-04-27
申请号：US15764804
申请日：2016-09-27
IPC分类号： A61K9/12 , A61K9/00 , A61K31/7048 , A61K47/12 , A61K47/02 , A61P17/04 , A61P17/10 , A61P17/06
摘要： A self-foaming composition is described that includes ivermectin, for a no-rinse topical application and for application to the skin. The composition can include: at least one intermediate composition B including a gas-generating agent; at least one intermediate composition A including an agent for activating the gas-generating agent; and ivermectin being present in the composition A, in the composition B, or simultaneously in the two compositions A and B. Also described, is a kit or a single container including a plurality of compartments including such a composition.
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公开(公告)号：US10857123B2
公开(公告)日：2020-12-08
申请号：US16072686
申请日：2017-01-25
IPC分类号： A61K31/341 , A61P17/04 , A61P17/06 , A61K9/00 , A61K31/381 , A61K31/4184 , A61K31/18 , A61K31/473 , A61K31/357 , A61K31/404
摘要： The use of an NLRP3 inhibitor compound is described in the treatment of inflammatory skin disorders, in particular psoriasis and atopic dermatitis.
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公开(公告)号：US10821076B2
公开(公告)日：2020-11-03
申请号：US15764242
申请日：2016-09-27
IPC分类号： A61K9/12 , A61K9/00 , A61K31/573 , A61P17/06 , A61K8/04 , A61K8/24 , A61K8/365 , A61K8/63 , A61K47/02 , A61K47/12 , A61Q19/00
摘要： A self-foaming composition for a topical application is described. The composition can include a medium which is cosmetically- or pharmaceutically-compatible with a topical application, and clobetasol propionate. The composition can include a small quantity of foaming surfactants. The composition includes: at least one intermediate composition B including a gas-generating agent; at least one intermediate composition A including an agent for activating the gas-generating agent; and clobetasol propionate being present in at least one of the intermediate compositions A and B. Also described, is a kit or a single container including a plurality of compartments including such a composition.
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公开(公告)号：US10647688B2
公开(公告)日：2020-05-12
申请号：US15537549
申请日：2015-12-17
发明人： Thibaud Portal
IPC分类号： C07D277/30 , C07D231/12 , C07D261/08 , C07D271/06 , A61K8/49 , C07D233/64 , C07D333/24 , C07D207/337 , C07D263/32 , C07D271/10 , A61Q19/00 , C07D249/08 , C07D285/12 , A61Q5/00 , A61Q19/08 , A61Q7/00 , C07D271/107
摘要： Novel compounds, synthesis methods and use of the same in medicine and in cosmetics are disclosed. Also disclosed, are novel compounds and ligands that modulate RARs.
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公开(公告)号：US20200062868A1
公开(公告)日：2020-02-27
申请号：US16322713
申请日：2017-08-02
发明人： Rachel AUZELY-VELTY , Tamiris FIGUEIREDO , Laura JING JING , Craig Steven HARRIS , Jean-Guy BOITEAU , Thibaut GERFAUD , Loic TOMAS
摘要： A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a backbone diol function of a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.
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公开(公告)号：US20200002441A1
公开(公告)日：2020-01-02
申请号：US16322653
申请日：2017-08-02
发明人： Rachel AUZELY-VELTY , Tamiris FIGUEIREDO , Laura JING JING , Craig Steven HARRIS , Jean-Guy BOITEAU , Thibaut GERFAUD , Loic TOMAS
摘要： A new hydrogel made of double crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Double crosslinked glycosaminoglycans, one linkage via two ether bonds with a hydroxyl group of each of two glycosaminoglycans and another linkage via an alkoxyboronate ester anion formed between a boronate hemiester grafted to one of the glycosaminoglycans and a diol function of to the other glycosaminoglycan. The diol function may be a backbone diol function or a diol portion of a diol functional moiety grafted the other glycosaminoglycan.
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公开(公告)号：US10370714B2
公开(公告)日：2019-08-06
申请号：US14129679
申请日：2012-06-25
申请人： Martin Steinhoff
发明人： Martin Steinhoff
IPC分类号： C12Q1/68 , C12Q1/6883
摘要： A method is described that uses ROR gamma t, or ROR alpha to diagnose rosacea and/or to screen inhibitors of Th17 differentiation, notably in inhibiting ROR gamma t or ROR alpha. Also described is a method of using these screened inhibitors in rosacea treatment.
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公开(公告)号：US20190225598A1
公开(公告)日：2019-07-25
申请号：US16373397
申请日：2019-04-02
IPC分类号： C07D409/06 , C07D405/12 , C07D213/38 , C07D307/52 , C07D213/75 , C07C381/10 , C07D407/12
摘要： Novel chemokine CXCR1 and CXCR2 receptor antagonist compounds of general formula (I) are described. Also described, are pharmaceutical compositions including the compounds, and use of the compounds and the compositions for the treatment of chemokine-mediated pathologies, more specifically in the field of dermatology.
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公开(公告)号：US20190209686A1
公开(公告)日：2019-07-11
申请号：US16238044
申请日：2019-01-02
发明人： Hans Christian WULF
IPC分类号： A61K41/00 , A61K31/22 , A61N5/06 , A61K31/197 , A61M37/00
CPC分类号： A61K41/0061 , A61K31/197 , A61K31/22 , A61M37/00 , A61M37/0015 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N5/062 , A61N2005/0652 , A61N2005/0653 , A61N2005/0657 , A61N2005/0663
摘要： A pulse photodynamic therapy (or pulse PDT) treatment of acne is described herein.
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