公开(公告)号：US20250059147A1

公开(公告)日：2025-02-20

申请号：US18816550

申请日：2024-08-27

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Allen Yu HONG ,  Jacob C. TIMMERMAN ,  Francis GOSSELIN ,  Katarzyna Aleksandra PIECHOWICZ ,  Filip PETRONIJEVIC ,  Kurt PUENTENER ,  Anna-Lena GLASS ,  Etienne TRACHSEL

IPC: C07D307/24 ,  B01J31/20 ,  B01J31/22 ,  B01J31/24 ,  C07D307/12 ,  C07D307/14 ,  C07D307/16

Abstract: Provided are phenyltetrahydrofuran compounds that are useful as intermediates in the preparation of pharmaceutical compounds and further provided are processes for the preparation of phenyltetrahydrofuran compounds.

公开(公告)号：US20250054630A1

公开(公告)日：2025-02-13

申请号：US18929474

申请日：2024-10-28

Applicant: Genentech, Inc.

Inventor： Cleopatra KOZLOWSKI ,  Daniel RUDERMAN

IPC: G16H50/20 ,  G16B15/00 ,  G16H10/60

Abstract: A method for image-based hepatocellular carcinoma (HCC) molecular subtype classification may include determining, within an image depicting a plurality of cells of a biological sample, a plurality of tiles with each tile depicting a portion of the plurality of cells comprising the sample. A machine learning model may be applied to determine a molecular subtype for the portion of the plurality of cells depicted in each tile. Moreover, an overall molecular subtype for the plurality of cells depicted in the image of the biological sample may be determined based on the molecular subtype of the portion of the plurality of cells depicted in each tile of the plurality of tiles. For example, another machine learning model may be applied to determine the overall molecular subtype of the plurality of cells depicted in the image of the biological sample. Related systems and computer program products are also provided.

公开(公告)号：US20250052759A1

公开(公告)日：2025-02-13

申请号：US18933358

申请日：2024-10-31

Applicant: Genentech, Inc.

Inventor： Marcin Kowanetz ,  Daniel Shin-Yu Chen ,  Hartmut Koeppen

IPC: G01N33/574 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  G06Q30/0241 ,  G06Q30/0251

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20250042919A1

公开(公告)日：2025-02-06

申请号：US18882588

申请日：2024-09-11

Applicant: Genentech, Inc.

Inventor： Lewis J. Gazzard ,  Samantha Alyson Green ,  Matthew Leo Landry ,  Sushant Malhotra ,  Michael Siu ,  Steven Do ,  Yun-Xing Cheng ,  Limin Cheng ,  Jianfeng Xin ,  Mingtao He

IPC: C07D498/22 ,  A61K31/553 ,  A61K45/06 ,  A61P35/00 ,  C07D519/00

Abstract: Provided herein are tetracyclic oxazepinyl compounds useful in the treatment on cancers.

公开(公告)号：US20250042917A1

公开(公告)日：2025-02-06

申请号：US18912279

申请日：2024-10-10

Applicant: Genentech, Inc.

Inventor： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC: C07D498/04 ,  A61K31/4375 ,  A61K31/5365 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P25/24 ,  A61P29/00 ,  C07D471/04

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US12214058B2

公开(公告)日：2025-02-04

申请号：US18056856

申请日：2022-11-18

Applicant: Genentech, Inc.

Inventor： Jan Marik ,  Joseph P. Lyssikatos ,  Simon Peter Williams

IPC: A61K51/04 ,  C07B59/00 ,  C07D487/04

Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.

公开(公告)号：US12209109B2

公开(公告)日：2025-01-28

申请号：US16782493

申请日：2020-02-05

Applicant: Chugai Seiyaku Kabushiki Kaisha ,  Genentech, Inc.

Inventor： Kelby Lau ,  Jean Bender ,  Saeko Tanaka ,  Rumiko Wakayama ,  Hidenari Yamada ,  Tomonori Isoda ,  Masayoshi Oh-Eda

IPC: C07K1/34 ,  A61K39/395 ,  B01D61/14 ,  B01D61/22 ,  C07K16/28

Abstract: The present invention provides a method for preparing a composition comprising highly concentrated antibodies by ultrafiltration in batch concentration mode having a first constant feed rate step and a second controlled feed rate step.

公开(公告)号：US12208088B2

公开(公告)日：2025-01-28

申请号：US17204089

申请日：2021-03-17

Applicant: Genentech, Inc.

Inventor： Sushant Malhotra ,  Craig Stivala ,  BinQing Wei ,  Bryan K. Chan ,  Timothy Heffron ,  Michael Lainchbury ,  Andrew Madin ,  Terry Aaron Panchal ,  Eileen Mary Seward ,  Toby Blench ,  Matthew W. Cartwright ,  Elsa Amandine Dechaux ,  Richard Elliott ,  Emanuela Gancia

IPC: A61K31/437 ,  A61K31/444 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/513 ,  A61K31/5377 ,  A61K45/06 ,  A61P35/00 ,  C07D471/04 ,  C07D471/10 ,  C07D471/20 ,  C07D487/04 ,  C07D487/20 ,  C07D491/20 ,  C07D519/00

Abstract: Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.

公开(公告)号：US20250026810A1

公开(公告)日：2025-01-23

申请号：US18674708

申请日：2024-05-24

Applicant: Genentech, Inc.

Inventor： Justin SCHEER ,  Whitney SHATZ ,  Domingos NG

IPC: C07K16/00 ,  C07K16/46 ,  C12N15/79 ,  C12N15/90

Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.

公开(公告)号：US20250011474A1

公开(公告)日：2025-01-09

申请号：US18762543

申请日：2024-07-02

Applicant: Genentech, Inc. ,  Novartis AG

Inventor： Ryan Patrick OWEN ,  Ahmar IQBAL ,  Robert A. WOOD

IPC: C07K16/42 ,  A61K39/00 ,  A61P37/08

Abstract: The present disclosure provides methods and kits for treating or preventing an allergic reaction to a food allergen consumed by a human subject with one or more food allergies. In particular, the present disclosure provides prophylactic therapies comprising administration of an anti-IgE antibody at a specific dose to a human subject who is allergic to one or more food allergens.