-
1.发明授权公开(公告)号：US11776664B2
公开(公告)日：2023-10-03
申请号：US16952566
申请日：2020-11-19
申请人： Genomic Health, Inc.
发明人： Wayne Cowens , Steven Shak , Audrey Goddard , Dejan Knezevic , Joffre Baker , Michael C. Kiefer , Tara Maddala , Frederick L. Baehner
IPC分类号： G01N33/574 , G16B99/00 , G16B25/10 , G06N7/01
CPC分类号： G16B99/00 , G01N33/57438 , G06N7/01 , G16B25/10 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
-
公开(公告)号：US11220715B2
公开(公告)日：2022-01-11
申请号：US15897617
申请日：2018-02-15
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/6886
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
-
公开(公告)号：US11149297B2
公开(公告)日：2021-10-19
申请号：US15866840
申请日：2018-01-10
申请人： Genomic Health, Inc.
发明人： Dominick Sinicropi , John Morlan
IPC分类号： C12Q1/68 , C12Q1/6806 , C12Q1/6848 , C12N15/10
摘要： The invention relates to methods of depleting RNA from a nucleic acid sample. The RNA may be any RNA, including, but not limited to, rRNA, tRNA, and mRNA. The method is useful for depleting RNA from a nucleic acid sample obtained from a fixed paraffin-embedded tissue (FPET) sample. The method may also be used to prepare cDNA, in particular, a cDNA library for further analysis or manipulation.
-
公开(公告)号：US20200165686A1
公开(公告)日：2020-05-28
申请号：US16612926
申请日：2018-05-17
申请人： Genomic Health, Inc.
发明人： Margarita LOPATIN , Athanasios TSIATIS , Christopher N. SILK , David P. Miller , Michael CRAGER , Phillip FEBBO , Dejan KNEZEVIC
IPC分类号： C12Q1/6886
摘要： The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.
-
公开(公告)号：US10241114B2
公开(公告)日：2019-03-26
申请号：US11450896
申请日：2006-06-09
IPC分类号： C12Q1/68 , G01N33/574 , C12N15/10 , C12Q1/6886
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
-
公开(公告)号：US10169530B2
公开(公告)日：2019-01-01
申请号：US14440582
申请日：2013-11-04
申请人： GENOMIC HEALTH, INC.
发明人： Yan Ma , Kunbin Qu , Mei-Lan Liu , Ranjana Ambannavar , James Stephans
IPC分类号： G06F19/18 , C12Q1/6886 , G06F19/22 , G16H50/20
摘要： The present invention relates to gene fusions and alternative spliced junctions associated with breast cancer. The present invention also relates to novel methods of identifying gene fusions and alternative spliced junctions in RNA sequencing data. The present invention further relates to predicting prognosis of a breast cancer patient based on the number of gene fusion events.
-
7.发明申请公开(公告)号：US20170121780A1
公开(公告)日：2017-05-04
申请号：US15368979
申请日：2016-12-05
申请人： GENOMIC HEALTH, INC.
发明人： Wayne COWENS , Steven SHAK , Audrey GODDARD , Dejan KNEZEVIC , Joffre BAKER , Michael C. KIEFER , Tara MADDALA , Frederick L. BAEHNER
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57438 , G06N7/005 , G16B99/00 , G16H50/20
摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
-
8.发明申请Gene Expression Profile Algorithm and Test for Determining Prognosis of Prostate Cancer 审中-公开基因表达谱算法和测定前列腺癌的预后公开(公告)号：US20140303002A1
公开(公告)日：2014-10-09
申请号：US14221556
申请日：2014-03-21
申请人： Genomic Health, Inc.
发明人： Steven Shak , Mark Lee , William F. Novotny , Tara Maddala , Michael R. Crager , Diana Cherbavaz , Robert J. Pelham , Carl L. Millward , Dejan Knezevic
CPC分类号： G16B25/00 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G16H50/30
摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes, or their co-expressed genes, from a biological sample obtained from a prostate cancer patient. The genes may be grouped into functional gene subsets for calculating a quantitative score useful to predict a likelihood of a clinical outcome for a prostate cancer patient.
摘要翻译： 本发明提供基于算法的分子测定法，其涉及从前列腺癌患者获得的生物样品中测量基因或其共表达基因的表达水平。 这些基因可以分组成功能性基因子集，用于计算可用于预测前列腺癌患者的临床结果的可能性的定量评分。
-
公开(公告)号：US20140287421A1
公开(公告)日：2014-09-25
申请号：US14257723
申请日：2014-04-21
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
摘要翻译： 本发明提供了在乳腺癌的诊断和/或预后中重要的基因组。
-
公开(公告)号：US08273537B2
公开(公告)日：2012-09-25
申请号：US12911519
申请日：2010-10-25
申请人： Drew Watson , Soonmyung Paik , Wayne Cowens , Joffre B. Baker , Kim Clark , James Hackett
发明人： Drew Watson , Soonmyung Paik , Wayne Cowens , Joffre B. Baker , Kim Clark , James Hackett
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.
-
-
-
-
-
-
-
-
-
搜索结果
92 条记录 (耗时 0.039 秒)
