DRUG DELIVERY SYSTEMS CONTAINING OXIDIZED CHOLESTEROLS

    公开(公告)号:US20240315983A1

    公开(公告)日:2024-09-26

    申请号:US18672534

    申请日:2024-05-23

    IPC分类号: A61K9/51 C12N15/113

    摘要: Lipid nanoparticles and compositions thereof are disclosed herein. An exemplary nanoparticle composition includes an ionizable lipid, a phospholipid, a PEG-lipid, and a cholesterol modified with a hydroxyl group near the D-sterol ring. The disclosed nanoparticle compositions can target liver Kupffer cells and endothelial cells more preferentially than hepatocytes which should be beneficial in treating liver diseases in which dysfunctional Kupffer cells and endothelial cells are involved in disease pathogenesis.