-
公开(公告)号：US20210269861A1
公开(公告)日：2021-09-02
申请号：US17029815
申请日：2020-09-23
申请人： Geron Corporation
IPC分类号： C12Q1/6813 , C12Q1/6883 , G16B30/00 , A61K48/00 , C12N15/113
摘要： The invention provides methods for determining the susceptibility of cancer patients to developing adverse reactions if treated with a telomerase inhibitor drug by measurement of telomere length in appropriate cells of the patient prior to initiation of the telomerase inhibitor treatment.
-
公开(公告)号：US20210147342A1
公开(公告)日：2021-05-20
申请号：US17079204
申请日：2020-10-23
申请人： Geron Corporation
IPC分类号： C07C233/18 , B01D9/00
摘要： Aspects of the disclosure include crystalline solids of 3-palmitoyl-amido-1,2-propanediol and 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane. Methods for preparing the crystalline solids of 3-palmitoyl-amido-1,2-propanediol and single crystals of 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane are also provided. Methods for preparing a 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane from a crystalline solid of 3-palmitoyl-amido-1,2-propanediol are also described.
-
公开(公告)号：US09572891B2
公开(公告)日：2017-02-21
申请号：US14728572
申请日：2015-06-02
申请人： Geron Corporation
IPC分类号： C07H21/00 , A61K31/7088 , A61K47/48
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
摘要翻译： 提供寡核苷酸共轭物，其中寡核苷酸共价连接到芳族体系上。 在具体实施方案中，寡核苷酸与人端粒酶的RNA组分互补，并通过任选的接头共价连接于核碱基。 缀合物抑制端粒酶的活性。
-
4.发明授权Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms 有权使用端粒酶抑制剂治疗骨髓增生性疾病和骨髓增生性肿瘤公开(公告)号：US09375485B2
公开(公告)日：2016-06-28
申请号：US13841711
申请日：2013-03-15
申请人： Geron Corporation
发明人： Monic J. Stuart , Stephen Kelsey
CPC分类号： C12N15/1135 , A61K47/543 , A61K47/549 , A61K49/0423 , B82Y5/00 , C12N2320/30
摘要： Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have Essential Thrombocythemia (ET). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having ET.
摘要翻译： 本文提供了减少肿瘤祖细胞增殖并减轻与诊断患有或被认为具有基础性血小板增多症（ET））的个体相关的症状的方法。 本文还提供了使用端粒酶抑制剂在被诊断患有或怀疑具有ET的个体的血液中在相对正常范围内维持血小板计数的方法。
-
5.发明申请Method for Eliciting an Immune Response to Human Telomerase Reverse Transcriptase 审中-公开引起人端粒酶逆转录酶免疫反应的方法公开(公告)号：US20150250863A1
公开(公告)日：2015-09-10
申请号：US14190021
申请日：2014-02-25
发明人： Thomas R. Cech , Joachim Lingner , Toru M. Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： A61K39/0011 , A01K2217/05 , A61K38/00 , A61K39/0005 , A61K39/39 , A61K48/00 , A61K2039/55505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , C07K14/43504 , C07K16/40 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/113 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Q1/6895 , C12Q2600/156 , C12Q2600/158 , C12Y207/07049
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
-
6.发明申请Synthetic Surfaces for Culturing Stem Cell Derived Oligodendrocyte Progenitor Cells 有权用于培养干细胞衍生的少突胶质细胞祖细胞的合成表面公开(公告)号：US20140134729A1
公开(公告)日：2014-05-15
申请号：US13946032
申请日：2013-07-19
IPC分类号： C12N5/079
CPC分类号： C12N5/0623 , C12M23/12 , C12N5/0068 , C12N5/0622 , C12N2500/90 , C12N2506/02 , C12N2533/30
摘要： Synthetic surfaces suitable for culturing stem cell derived oligodendrocyte progenitor cells contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived oligodendrocyte progenitor cells in chemically defined media.
摘要翻译： 适于培养干细胞衍生的少突胶质细胞祖细胞的合成表面含有由一种或多种丙烯酸酯单体形成的丙烯酸酯聚合物。 在许多情况下，丙烯酸酯表面适合于在化学上限定的培养基中培养干细胞衍生的少突胶质细胞祖细胞。
-
公开(公告)号：US08563312B2
公开(公告)日：2013-10-22
申请号：US13546381
申请日：2012-07-11
CPC分类号： C12N5/0657 , C12N5/0068 , C12N2500/90 , C12N2506/02 , C12N2533/30
摘要： Synthetic surfaces suitable for culturing stem cell derived cardiomyocytes contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived cardiomyocytes in chemically defined media.
摘要翻译： 适合于培养干细胞衍生的心肌细胞的合成表面含有由一种或多种丙烯酸酯单体形成的丙烯酸酯聚合物。 在许多情况下，丙烯酸酯表面适合于在化学上限定的培养基中培养干细胞来源的心肌细胞。
-
8.发明授权Compound screening using chondrocytes derived from primate pluripotent stem cells 有权使用源自灵长类动物多能干细胞的软骨细胞进行复合筛选公开(公告)号：US08546101B2
公开(公告)日：2013-10-01
申请号：US13021497
申请日：2011-02-04
申请人： R. Scott Thies
发明人： R. Scott Thies
CPC分类号： C12N5/0655 , A61K35/12 , C12N2500/44 , C12N2501/115 , C12N2501/15 , C12N2501/395 , C12N2501/41 , C12N2506/02 , C12N2510/00
摘要： This invention provides a system for obtaining cells of the chondrocyte lineage by differentiating primate pluripotent stem cells. The process involves culturing the cells as a micromass or other aggregate form in a cocktail of differentiation agents that facilitates outgrowth of the desired cell type. Progeny are capable of synthesizing Type II collagen or aggrecan, or other products that are characteristic of the chondrocyte lineage. Chondrocytes and chondrocyte precursor cells obtained according to this disclosure are suitable for use in both research and clinical therapy.
摘要翻译： 本发明提供了一种通过分化灵长类多能干细胞来获得软骨细胞谱系细胞的系统。 该方法包括在促进所需细胞类型的生长的分化试剂的混合物中以细微或其它聚集形式培养细胞。 后代能够合成II型胶原蛋白或聚集蛋白聚糖，或其他属于软骨细胞谱系特征的产品。 根据本公开获得的软骨细胞和软骨细胞前体细胞适用于研究和临床治疗。
-
公开(公告)号：US20130253042A1
公开(公告)日：2013-09-26
申请号：US13892065
申请日：2013-05-10
申请人： GERON CORPORATION
IPC分类号： A61K47/48
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
-
10.发明授权2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use 有权2'-阿拉伯 - 氟代寡核苷酸N 3'→P 5'氨基磷酸酯：它们的合成和用途公开(公告)号：US08377644B2
公开(公告)日：2013-02-19
申请号：US13192035
申请日：2011-07-27
申请人： Sergei Gryaznov , Ronald G. Schultz
发明人： Sergei Gryaznov , Ronald G. Schultz
CPC分类号： C07H19/20 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H21/00 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12Q1/6813 , C12Q1/6816 , C12Q1/6876 , C12Q2600/158 , C12Q2563/107 , C12Q2525/113
摘要： Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-aribino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.
摘要翻译： 具有含有至少一个2'-阿氨基 - 氟核苷和核苷间3'-NH-P（= O）（OR）-O-5'键的新型糖 - 磷酸骨架的寡核苷酸，其中R是带正电荷的对离子或 氢，以及合成和使用本发明的寡核苷酸的方法。 本发明的氨基磷酸2'-亚氨基 - 低聚核苷酸对互补核酸具有高的RNA结合亲和力，并且是碱和酸稳定的。
-
-
-
-
-
-
-
-
-
搜索结果
221 条记录 (耗时 0.039 秒)
