公开(公告)号：US20240318232A1

公开(公告)日：2024-09-26

申请号：US18491658

申请日：2023-10-20

申请人： Geron Corporation

发明人： Calvin B. Harley ,  Laurence Elias ,  Jennifer Smith ,  Mark J. Ratain ,  Fabio Benedetti

IPC分类号： C12Q1/6813 ,  A61K48/00 ,  C12N15/113 ,  C12Q1/6883 ,  G16B30/00

CPC分类号： C12Q1/6813 ,  A61K48/00 ,  C12N15/1137 ,  C12Q1/6883 ,  G16B30/00 ,  C12Q2600/106 ,  C12Q2600/156

摘要： The invention provides methods for determining the susceptibility of cancer patients to developing adverse reactions if treated with a telomerase inhibitor drug by measurement of telomere length in appropriate cells of the patient prior to initiation of the telomerase inhibitor treatment.

公开(公告)号：US20240300992A1

公开(公告)日：2024-09-12

申请号：US18490328

申请日：2023-10-19

申请人： Geron Corporation

发明人： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC分类号： C07H19/16 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12

CPC分类号： C07H19/16 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12

摘要： Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

公开(公告)号：US20240034748A1

公开(公告)日：2024-02-01

申请号：US18074179

申请日：2022-12-02

申请人： Geron Corporation

发明人： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Daria Zielinska

IPC分类号： C07H19/16 ,  C07H19/06 ,  C07H19/12 ,  C07H19/10

CPC分类号： C07H19/16 ,  C07H19/06 ,  C07H19/12 ,  C07H19/10

摘要： Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.

公开(公告)号：US11739114B2

公开(公告)日：2023-08-29

申请号：US17696300

申请日：2022-03-16

申请人： Geron Corporation

发明人： Premchandran H. Ramiya

IPC分类号： C07H21/00 ,  C12N15/113 ,  C12P19/34

CPC分类号： C07H21/00 ,  C12N15/113 ,  C12N15/1137 ,  C12P19/34 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/3145 ,  C12N2310/3515 ,  C12Y207/07049 ,  C12N2310/3145 ,  C12N2310/315

摘要： The present disclosure provides a solid phase method of making oligonucleotides via sequential coupling cycles including at least one coupling of a dinucleotide dimer subunit to a free 3′-terminal group of a growing chain. The oligonucleotides include at least two nucleoside subunits joined by a N3′→P5′ phosphoramidate linkage. The method may include the steps of (a) deprotecting the protected 3′ amino group of a terminal nucleoside attached to a solid phase support, said deprotecting forming a free 3′ amino group; (b) contacting the free 3′ amino group with a 3′-protected amino-dinucleotide-5′-phosphoramidite dimer in the presence of a nucleophilic catalyst to form an internucleoside N3′→P5′ phosphoramidite linkage; and (c) oxidizing (e.g., sulfurizing) the linkage. The compositions produced by the subject methods may include a reduced amount of one or more (N−x) oligonucleotide products. Also provided are pharmaceutical compositions including the subject oligonucleotide compositions.

公开(公告)号：US20210269861A1

公开(公告)日：2021-09-02

申请号：US17029815

申请日：2020-09-23

申请人： Geron Corporation

发明人： Calvin B. Harley ,  Laurence Elias ,  Jennifer Smith ,  Mark J. Ratain ,  Fabio Benedetti

IPC分类号： C12Q1/6813 ,  C12Q1/6883 ,  G16B30/00 ,  A61K48/00 ,  C12N15/113

摘要： The invention provides methods for determining the susceptibility of cancer patients to developing adverse reactions if treated with a telomerase inhibitor drug by measurement of telomere length in appropriate cells of the patient prior to initiation of the telomerase inhibitor treatment.

公开(公告)号：US20210147342A1

公开(公告)日：2021-05-20

申请号：US17079204

申请日：2020-10-23

申请人： Geron Corporation

发明人： Jennifer E. Albaneze-Walker

IPC分类号： C07C233/18 ,  B01D9/00

摘要： Aspects of the disclosure include crystalline solids of 3-palmitoyl-amido-1,2-propanediol and 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane. Methods for preparing the crystalline solids of 3-palmitoyl-amido-1,2-propanediol and single crystals of 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane are also provided. Methods for preparing a 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane from a crystalline solid of 3-palmitoyl-amido-1,2-propanediol are also described.

公开(公告)号：US09572891B2

公开(公告)日：2017-02-21

申请号：US14728572

申请日：2015-06-02

申请人： Geron Corporation

发明人： Sergei M. Gryaznov ,  Krisztina Pongracz ,  Richard L. Tolman ,  Gregg B. Morin

IPC分类号： C07H21/00 ,  A61K31/7088 ,  A61K47/48

CPC分类号： A61K47/48092 ,  A61K47/549 ,  C07H21/00

摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.

摘要翻译： 提供寡核苷酸共轭物，其中寡核苷酸共价连接到芳族体系上。 在具体实施方案中，寡核苷酸与人端粒酶的RNA组分互补，并通过任选的接头共价连接于核碱基。 缀合物抑制端粒酶的活性。

公开(公告)号：US09375485B2

公开(公告)日：2016-06-28

申请号：US13841711

申请日：2013-03-15

申请人： Geron Corporation

发明人： Monic J. Stuart ,  Stephen Kelsey

IPC分类号： A61K47/48 ,  A61K49/04 ,  B82Y5/00

CPC分类号： C12N15/1135 ,  A61K47/543 ,  A61K47/549 ,  A61K49/0423 ,  B82Y5/00 ,  C12N2320/30

摘要： Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have Essential Thrombocythemia (ET). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having ET.

摘要翻译： 本文提供了减少肿瘤祖细胞增殖并减轻与诊断患有或被认为具有基础性血小板增多症（ET））的个体相关的症状的方法。 本文还提供了使用端粒酶抑制剂在被诊断患有或怀疑具有ET的个体的血液中在相对正常范围内维持血小板计数的方法。

公开(公告)号：US20150250863A1

公开(公告)日：2015-09-10

申请号：US14190021

申请日：2014-02-25

申请人： The Regents of the University of Colorado ,  Geron Corporation

发明人： Thomas R. Cech ,  Joachim Lingner ,  Toru M. Nakamura ,  Karen B. Chapman ,  Gregg B. Morin ,  Calvin B. Harley ,  William H. Andrews

IPC分类号： A61K39/00 ,  C12N9/12

CPC分类号： A61K39/0011 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/0005 ,  A61K39/39 ,  A61K48/00 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/43504 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/1241 ,  C12N9/1276 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/15 ,  C12N2310/315 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y207/07049

摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。

公开(公告)号：US20140134729A1

公开(公告)日：2014-05-15

申请号：US13946032

申请日：2013-07-19

申请人： Christopher Bankole Shogbon ,  Yue Zhou ,  Ralph Brandenberger

发明人： Christopher Bankole Shogbon ,  Yue Zhou ,  Ralph Brandenberger

IPC分类号： C12N5/079

CPC分类号： C12N5/0623 ,  C12M23/12 ,  C12N5/0068 ,  C12N5/0622 ,  C12N2500/90 ,  C12N2506/02 ,  C12N2533/30

摘要： Synthetic surfaces suitable for culturing stem cell derived oligodendrocyte progenitor cells contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived oligodendrocyte progenitor cells in chemically defined media.

摘要翻译： 适于培养干细胞衍生的少突胶质细胞祖细胞的合成表面含有由一种或多种丙烯酸酯单体形成的丙烯酸酯聚合物。 在许多情况下，丙烯酸酯表面适合于在化学上限定的培养基中培养干细胞衍生的少突胶质细胞祖细胞。