公开(公告)号：US5626841A

公开(公告)日：1997-05-06

申请号：US254922

申请日：1994-06-07

申请人： Victor Gurewich

发明人： Victor Gurewich

IPC分类号： A61K38/49 ,  C12N15/57 ,  C12N9/64 ,  C12N9/72

CPC分类号： A61K38/49

摘要： A method of adjunctive therapy to inhibit reocclusions in a patient, e.g., after thrombolytic therapy or angioplasty, by administering to the patient a bolus of an amount of purified pro-urokinase ("pro-UK") that inhibits the formation of occlusive thrombi without inducing a systemic effect in the patient, the pro-UK is administered after the completion of the thrombolytic treatment and periodically thereafter for the duration of therapy, and becomes incorporated into the outer membrane of the platelets of the patient, thereby increasing the T.sub. 1/2 of the pro-UK in plasma, which is about 7 to 8 minutes, to about 4 to 5 days, and inhibiting reocclusion without inducing a systemic effect.

摘要翻译： 一种辅助治疗方法，例如在溶栓治疗或血管成形术之后，通过对患者施用一定量的纯化的尿激酶（“pro-UK”），其抑制闭塞血栓的形成而不在 在患者中引起全身效应，在溶栓治疗完成后施用pro-UK，并在治疗期间定期施用，并且将其并入患者血小板的外膜中，从而增加T + E ，英制血浆中的1/2 + EE，其为约7至8分钟至约4至5天，并且抑制再闭合而不引起全身作用。