公开(公告)号：US07951102B2

公开(公告)日：2011-05-31

申请号：US10572946

申请日：2004-09-20

Applicant: Amit Gefen ,  Michal Peleg Lubovsky ,  Omri Lubovsky

Inventor： Amit Gefen ,  Michal Peleg Lubovsky ,  Omri Lubovsky

IPC: A61F5/00

CPC classification number: A61F5/3707 ,  A61F5/055 ,  Y10S128/23

Abstract: The present invention discloses a novel cervical collar for maintaining the airways in head and neck immobilized trauma patient open. This collar comprises a rigid motion-restricting frame (220, 230, 240, 270, 280) attached to the head (100); and, a jaw clasp (210, 290) attached to the jaw (110). The collar is simultaneously restricting the motion of the head (100) and neck while allowing motion of the jaw (110) to maintain open airways. A jaw clasp (290) useful for performing the jaw-thrust maneuver motion of the jaw (110) to maintain open airways is also presented. Said device comprising a plurality of movable fitting elements adapted to fit the jaw (110) tightly; and, a plurality of movable mover elements adapted to move the jaw (110).

Abstract translation: 本发明公开了一种用于保持头颈固定创伤患者开放的气道的新型颈环。 该套环包括附接到头部（100）的刚性运动限制框架（220,230,240,270,280）; 以及附接到所述钳口（110）的钳夹（210,290）。 颈圈同时限制头部（100）和颈部的运动，同时允许钳口（110）的运动保持开放的气道。 还提出了可用于执行钳口（110）的颚式推动机动运动以保持开放气道的钳口钩（290）。 所述装置包括适于紧紧地装配钳口（110）的多个可动配件元件; 以及适于移动所述钳口（110）的多个可动移动元件。

公开(公告)号：US20040161457A1

公开(公告)日：2004-08-19

申请号：US10778738

申请日：2004-02-13

Applicant: Alza Corporation ,  Hadasit Medical Research and Development Ltd.

Inventor： Alberto A. Gabizon ,  Samuel Zalipsky ,  Dorit Goren-Rubel ,  Aviva T. Horowitz

IPC: A61K009/127 ,  A61K038/16

CPC classification number: A61K31/704 ,  A61K9/1271

Abstract: A composition for administration of a therapeutic compound to a multi-drug resistant cell in a person suffering from a drug-resistant cancer is described. The composition is composed of a carrier molecule and a folate targeting ligand, which is covalently attached to the carrier, and the therapeutic compound. In one preferred embodiment, the carrier is a liposome having a surface coating of hydrophilic polymer chains where a folate ligand is attached to the free distal end of at least a portion of the hydrophilic polymer chains, and the therapeutic agent is entrapped in the liposomes. The composition is effective to achieve accumulation of the therapeutic compound in the cell in an amount sufficient to be cytotoxic. Also described are methods for administering a therapeutic compound to a person suffering from a multi-drug resistant condition.

Abstract translation: 描述了一种用于在耐药性癌症患者中向多药耐药细胞施用治疗化合物的组合物。 组合物由载体分子和共价连接到载体的叶酸靶向配体和治疗化合物组成。 在一个优选的实施方案中，载体是具有亲水性聚合物链的表面涂层的脂质体，其中叶酸配体连接至亲水性聚合物链的至少一部分的游离远端，并且治疗剂被截留在脂质体中。 该组合物有效地实现治疗化合物在细胞中以足以成为细胞毒性的量的积累。 还描述了向患有多重耐药性病症的人施用治疗化合物的方法。

公开(公告)号：US10266897B2

公开(公告)日：2019-04-23

申请号：US15914112

申请日：2018-03-07

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Rifaat Safadi

IPC: C07H21/02 ,  C07H21/04 ,  C12Q1/6883 ,  A61K31/7088 ,  A61K45/06 ,  C12N15/113 ,  A61K31/713 ,  A61K31/7105

Abstract: A kit having a means for isolating an immune cell population from a biological sample of a patient; and at least one agent capable of detecting NLGn4 gene product expression level.

公开(公告)号：US20060062842A1

公开(公告)日：2006-03-23

申请号：US11220901

申请日：2005-09-06

Applicant: Alberto Gabizon ,  Samuel Zalipsky ,  Dorit Goren-Rubel ,  Aviva Horowitz

Inventor： Alberto Gabizon ,  Samuel Zalipsky ,  Dorit Goren-Rubel ,  Aviva Horowitz

IPC: A61K9/127 ,  A61K38/16 ,  A61K31/704

CPC classification number: A61K31/704 ,  A61K9/1271

Abstract: A composition for administration of a therapeutic compound to a multi-drug resistant cell in a person suffering from a drug-resistant cancer is described. The composition is composed of a carrier molecule and a folate targeting ligand, which is covalently attached to the carrier, and the therapeutic compound. In one preferred embodiment, the carrier is a liposome having a surface coating of hydrophilic polymer chains where a folate ligand is attached to the free distal end of at least a portion of the hydrophilic polymer chains, and the therapeutic agent is entrapped in the liposomes. The composition is effective to achieve accumulation of the therapeutic compound in the cell in an amount sufficient to be cytotoxic. Also described are methods for administering a therapeutic compound to a person suffering from a multi-drug resistant condition.

Abstract translation: 描述了一种用于在耐药性癌症患者中向多药耐药细胞施用治疗化合物的组合物。 组合物由载体分子和共价连接到载体的叶酸靶向配体和治疗化合物组成。 在一个优选的实施方案中，载体是具有亲水性聚合物链的表面涂层的脂质体，其中叶酸配体连接至亲水性聚合物链的至少一部分的游离远端，并且治疗剂被截留在脂质体中。 该组合物有效地实现治疗化合物在细胞中以足以成为细胞毒性的量的积累。 还描述了向患有多重耐药性病症的人施用治疗化合物的方法。