公开(公告)号：US20220081427A1

公开(公告)日：2022-03-17

申请号：US17523949

申请日：2021-11-11

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRADI ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/433 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D409/14 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20190194176A1

公开(公告)日：2019-06-27

申请号：US16288276

申请日：2019-02-28

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRADI ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/519 ,  A61K31/381 ,  A61K31/498 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/401 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D417/04 ,  C07D413/14 ,  C07D413/04 ,  C07D409/14 ,  A61K31/433 ,  A61K31/4985

CPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20200277285A1

公开(公告)日：2020-09-03

申请号：US15930067

申请日：2020-05-12

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRADI ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/433 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D409/14 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20180319780A1

公开(公告)日：2018-11-08

申请号：US16039441

申请日：2018-07-19

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRAD! ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/519 ,  A61K31/381 ,  A61K31/498 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/401 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D417/04 ,  C07D413/14 ,  C07D413/04 ,  C07D409/14 ,  A61K31/433 ,  A61K31/4985

CPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20180037577A1

公开(公告)日：2018-02-08

申请号：US15786626

申请日：2017-10-18

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRADI ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/4985 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/381 ,  A61K31/433 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/519 ,  C07D409/14 ,  C07D413/04

CPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US09796706B2

公开(公告)日：2017-10-24

申请号：US15391645

申请日：2016-12-27

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. Sham ,  Roy K. Hom ,  Andrei W. Konradi ,  Gary D. Probst ,  Simeon Bowers ,  Anh Truong ,  R. Jeffrey Neitz ,  Jennifer Sealy ,  Gergely Toth

IPC分类号： C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/381 ,  A61K31/433 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519

CPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US09493485B2

公开(公告)日：2016-11-15

申请号：US14386722

申请日：2013-03-20

申请人： Imago Pharmaceuticals, Inc.

发明人： Ying-Zi Xu ,  Dean R. Artis ,  Simeon Bowers ,  Roy K. Hom ,  Hing L. Sham ,  Shendong Yuan

IPC分类号： C07D513/10 ,  C07D417/12 ,  C07D413/14 ,  C07D413/10 ,  C07D413/12 ,  C07D265/12 ,  C07D265/18 ,  C07D498/10 ,  C07D279/16

CPC分类号： C07D513/10 ,  C07D265/12 ,  C07D265/18 ,  C07D279/08 ,  C07D279/16 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/10

摘要： Compounds are provided having a structure according to Formula (I): wherein A1, A2, A3, Y, R1, R2, R3, R4, R5, R6, m, n and p are defined herein. Further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US10766954B2

公开(公告)日：2020-09-08

申请号：US16092055

申请日：2017-04-05

申请人： Imago Pharmaceuticals, Inc.

发明人： Irene Griswold-Prenner ,  Karen Chen

IPC分类号： C07K16/18 ,  A61P25/00 ,  A61P25/28 ,  A61P25/16

摘要： The invention provides therapeutic antibodies and methods for treatment of diseases associated with diseases associated with aggregation of α-synuclein, e.g., in the brain of a subject. Such methods provide administration of therapeutic antibodies to elicit a beneficial immunogenic response against aggregation of α-synuclein. The methods are particularly useful for prophylactic and therapeutic treatment of diseases associated with the formation of Lewy bodies, e.g., Parkinson's disease.

公开(公告)号：US09884828B2

公开(公告)日：2018-02-06

申请号：US14122199

申请日：2012-05-21

申请人： Danielle L. Aubele ,  Albert W. Garofalo ,  Simeon Bowers ,  Anh P. Truong ,  Xiaocong Michael Ye ,  Maurizio Franzini ,  Marc Adler ,  R. Jeffrey Neitz ,  Gary Probst

发明人： Danielle L. Aubele ,  Albert W. Garofalo ,  Simeon Bowers ,  Anh P. Truong ,  Xiaocong Michael Ye ,  Maurizio Franzini ,  Marc Adler ,  R. Jeffrey Neitz ,  Gary Probst

IPC分类号： A61K31/502 ,  C07D237/28 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D417/04 ,  C07D413/10

CPC分类号： C07D237/28 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D413/10 ,  C07D417/04

摘要： The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

公开(公告)号：US20160272654A1

公开(公告)日：2016-09-22

申请号：US15169978

申请日：2016-06-01

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Ying-Zi XU ,  Dean R. Artis ,  Simeon Bowers ,  Roy K. Hom ,  Hing L. Sham ,  Shendong Yuan

IPC分类号： C07D513/10 ,  C07D417/12 ,  C07D417/14 ,  C07D279/08

CPC分类号： C07D513/10 ,  C07D265/12 ,  C07D265/18 ,  C07D279/08 ,  C07D279/16 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/10

摘要： Compounds are provided having a structure according to Formula (I): wherein A1, A2, A3, Y, R1, R2, R3, R4, R5, R6, m, n and p are defined herein. Further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.