公开(公告)号：US20240050437A1

公开(公告)日：2024-02-15

申请号：US18072314

申请日：2022-11-30

申请人： Infinity Pharmaceuticals, Inc.

发明人： Jeffery L. Kutok ,  David G. Winkler ,  Vito J. Palombella ,  Alfredo C. Castro ,  Catherine A. Evans ,  Somarajannair Janardanannair ,  Andre Lescarbeau ,  Tao Liu ,  Martin R. Tremblay

IPC分类号： A61K31/5377 ,  A61K45/06 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/517 ,  A61K31/519 ,  A61K31/337 ,  A61K31/427 ,  A61K31/495 ,  A61K31/506 ,  A61K39/00 ,  A61K39/395

CPC分类号： A61K31/5377 ,  A61K2300/00 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/517 ,  A61K31/519 ,  A61K31/337 ,  A61K31/427 ,  A61K31/495 ,  A61K31/506 ,  A61K39/0005 ,  A61K39/39533 ,  A61K39/39566 ,  A61K2039/505 ,  A61K45/06

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

公开(公告)号：US20240050432A1

公开(公告)日：2024-02-15

申请号：US18265915

申请日：2021-12-07

申请人： Infinity Pharmaceuticals, Inc.

发明人： Brenda Carol O'Connell

IPC分类号： A61K31/519 ,  A61K39/395 ,  A61K31/337 ,  A61P35/04 ,  C07K16/28 ,  A61P35/00

CPC分类号： A61K31/519 ,  A61K39/3955 ,  A61K31/337 ,  A61P35/04 ,  C07K16/2818 ,  A61P35/00 ,  C07K16/2827 ,  A61K2039/505

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

公开(公告)号：US11602527B2

公开(公告)日：2023-03-14

申请号：US17035611

申请日：2020-09-28

申请人： Infinity Pharmaceuticals, Inc.

发明人： Alfredo C. Castro ,  Michael J. Grogan ,  Karen J. McGovern ,  Martin R. Tremblay

IPC分类号： A61K31/4355 ,  C07D307/94 ,  C07D471/04 ,  C07D471/10 ,  A61K31/58 ,  C07D491/04 ,  C07D491/10 ,  C07J69/00 ,  A61K31/17 ,  A61K31/196 ,  A61K31/198 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/56 ,  A61K31/573 ,  A61K31/664 ,  A61K31/69 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7076 ,  A61K38/21 ,  C07D491/107 ,  A61K45/06 ,  C07D491/048 ,  A61K9/00 ,  A61N5/10

摘要： The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:

公开(公告)号：US20220372038A1

公开(公告)日：2022-11-24

申请号：US17202195

申请日：2021-03-15

申请人： Infinity Pharmaceuticals, Inc.

发明人： Alfredo C. Castro ,  Catherine A. Evans ,  Somarajannair Janardanannair ,  Andre Lescarbeau ,  Tao Liu ,  Martin R. Tremblay

IPC分类号： C07D487/04 ,  C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

公开(公告)号：US11247995B2

公开(公告)日：2022-02-15

申请号：US16197195

申请日：2018-11-20

申请人： Infinity Pharmaceuticals, Inc.

发明人： Louis Grenier ,  Andre Lescarbeau ,  Praveen Sharma ,  Daniel G. Genov

IPC分类号： C07D487/04 ,  A61K9/48 ,  A61K31/519 ,  C07D231/12 ,  C07D231/38 ,  C07D401/06

摘要： Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphic forms, cocrystals, and amorphous forms thereof, and pharmaceutical compositions thereof.

公开(公告)号：US20210000837A1

公开(公告)日：2021-01-07

申请号：US16816132

申请日：2020-03-11

申请人： Infinity Pharmaceuticals, Inc.

发明人： Jeffery L. Kutok ,  David G. Winkler ,  Vito J. Palombella ,  Alfredo C. Castro ,  Catherine A. Evans ,  Somarajannair Janardanannair ,  Andre Lescarbeau ,  Tao Liu ,  Martin R. Tremblay

IPC分类号： A61K31/5377 ,  A61K45/06 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/517 ,  A61K31/519 ,  A61K31/337 ,  A61K31/427 ,  A61K31/495 ,  A61K31/506 ,  A61K39/00 ,  A61K39/395

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

公开(公告)号：US20170360795A1

公开(公告)日：2017-12-21

申请号：US15421020

申请日：2017-01-31

申请人： INFINITY PHARMACEUTICALS, INC.

发明人： Howard M. Stern ,  Jeffery L. Kutok

IPC分类号： A61K31/52 ,  A61K39/395 ,  A61K45/06 ,  A61K31/519 ,  C07D473/34 ,  C07K16/28 ,  C12Q1/68

CPC分类号： A61K31/52 ,  A61K31/519 ,  A61K39/39558 ,  A61K45/06 ,  C07D473/34 ,  C07K16/2887 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  A61K2300/00

摘要： Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders.

公开(公告)号：US09738644B2

公开(公告)日：2017-08-22

申请号：US14869637

申请日：2015-09-29

申请人： Infinity Pharmaceuticals, Inc.

发明人： Pingda Ren ,  Yi Liu ,  Liansheng Li ,  Katrina Chan ,  Alfredo C. Castro ,  Catherine A. Evans

IPC分类号： A01N43/64 ,  A61K31/53 ,  A01N43/66 ,  A01N43/90 ,  A61K31/52 ,  A61K31/519 ,  A01N43/54 ,  A61K31/505 ,  C07D473/34 ,  A61K31/47 ,  C07D401/14 ,  C07D473/16 ,  C07D473/32 ,  C07D487/04

CPC分类号： C07D473/34 ,  A61K31/47 ,  A61K31/52 ,  C07D401/14 ,  C07D473/16 ,  C07D473/32 ,  C07D487/04 ,  Y02A50/414 ,  Y02A50/463

摘要： Substituted isoquinolinone compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

公开(公告)号：US09708348B2

公开(公告)日：2017-07-18

申请号：US14874328

申请日：2015-10-02

申请人： Infinity Pharmaceuticals, Inc.

发明人： Alfredo C. Castro ,  Catherine A. Evans ,  Martin R. Tremblay

IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  A01N43/90 ,  A61K31/519 ,  A01N43/42 ,  A61K31/44 ,  C07D487/00 ,  C07D401/00 ,  C07D403/00 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00 ,  C07D471/02 ,  C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

摘要： Trisubstituted bicyclic heterocyclic compounds (e.g., chromenones and quinolines) and pharmaceutical compositions,that modulate kinase activity, including PI3 kinase activity, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

公开(公告)号：US09481667B2

公开(公告)日：2016-11-01

申请号：US14209842

申请日：2014-03-13

申请人： Infinity Pharmaceuticals, Inc.

发明人： Daniel G. Genov ,  Louis Grenier ,  Andrew B. Hague ,  Alexander Redvers Eberlin ,  Ludovic Sylvain Marc Renou ,  Susana Del Rio Gancedo

IPC分类号： C07D401/14 ,  A61K31/4725

CPC分类号： C07D401/14 ,  A61K31/4725

摘要： Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, solid forms thereof, and pharmaceutical compositions thereof.

摘要翻译： 本文描述了调节激酶活性（包括PI3激酶活性）的化合物的固体形式，以及化合物，药物组合物和治疗与激酶活性（包括PI3激酶活性）相关的疾病和病症的方法。 本文还提供了制备化合物，其固体形式及其药物组合物的方法。