公开(公告)号：US5352603A

公开(公告)日：1994-10-04

申请号：US661378

申请日：1991-02-28

申请人： Roman Vetter ,  Detlef Wilke ,  Antoine Amory ,  Andre Clippe ,  Dietmar Schomburg ,  Wolfgang Aehle

发明人： Roman Vetter ,  Detlef Wilke ,  Antoine Amory ,  Andre Clippe ,  Dietmar Schomburg ,  Wolfgang Aehle

IPC分类号： C12N1/21 ,  C12N9/54 ,  C12N15/57 ,  C11D3/386 ,  C11D7/42 ,  C12N9/52

CPC分类号： C12N9/54

摘要： Novel, optimized highly alkaline proteases which are suitable for use in detergent formulations are prepared by employing microorganisms transformed by mutated DNA sequences. The mutated sequences are obtained starting from DNA sequences which code for highly alkaline protease usually produced by Bacillus species by altering these DNA sequences in defined positions by directed mutagenesis (point mutation) in such a way that the codon in which the point mutation is located now codes for an amino acid which is more strongly basic than the original amino acid. The result is highly alkaline proteases in which original amino acids have been replaced by more strongly basic amino acids, preferably by the amino acids lysine or arginine. Synthetic oligonucleotides, DNA sequences, vectors and transformed microorganisms which are used for generating and obtaining the optimized highly alkaline protease are also described.

摘要翻译： 通过使用通过突变的DNA序列转化的微生物来制备适用于洗涤剂制剂的新型优化的高碱性蛋白酶。 突变序列从编码通过芽孢杆菌属物种生产的高度碱性蛋白酶的DNA序列开始获得，通过定点诱变（点突变）以定点诱变（点突变）改变这些DNA序列，使得点突变位于的密码子现在 编码比原始氨基酸更强碱性的氨基酸。 结果是高碱性蛋白酶，其中原始氨基酸已被更强碱性氨基酸替代，优选由氨基酸赖氨酸或精氨酸代替。 还描述了用于产生和获得优化的高碱性蛋白酶的合成寡核苷酸，DNA序列，载体和转化微生物。

公开(公告)号：US5229284A

公开(公告)日：1993-07-20

申请号：US737983

申请日：1991-07-30

申请人： Dirk Bonse ,  Hubert Schindler ,  Hans-Joerg Mueller

发明人： Dirk Bonse ,  Hubert Schindler ,  Hans-Joerg Mueller

IPC分类号： C12N11/14 ,  C12P19/24

CPC分类号： C12N11/14 ,  C12P19/24

摘要： Enzymes are immboilized on an inorganic carrier which is a round, macropermeable agglomerate having a mulberry-type structure formed from spherical microporous .alpha.-aluminum oxide hydroxide particles. An organic polycondensate having free organic functional groups as enzyme binding sites penetrates the agglomerate. The .alpha.-aluminum oxide hydroxide particles of the agglomerate retain essentially their form prior to agglomeration. The polycondensate is prepared by reacting a polyimine with a dialdehyde or an epoxy compound. Preferably, the polyimine is polyethyleneimine, the dialdehyde is glutardialdehyde and the epoxy compound is an epoxy-functional silicon resin, an aliphatic diepoxide or an aliphatic triepoxide. The agglomerate is prepared by granulating the .alpha.-aluminum oxide hydroxide particles in the presence of the polyimine to form the agglomerate having the polyimine dispersed throughout and then reacting the polyimine with the dialdehyde or the epoxy compound. A preferred enzyme is glucose isomerase.

摘要翻译： 酶在无机载体上进行无菌化，该无机载体是具有由球形微孔α-铝氧化物氢氧化物颗粒形成的桑树型结构的圆形，可渗透聚集体。 具有游离有机官能团作为酶结合位点的有机缩聚物渗透附聚物。 附聚物的α-二氧化铝氢氧化物颗粒在凝聚之前基本保持其形式。 缩聚物通过聚亚胺与二醛或环氧化合物反应来制备。 优选地，聚亚胺是聚乙烯亚胺，二醛是戊二醛，环氧化合物是环氧官能的硅树脂，脂族二环氧化物或脂族三环氧化物。 通过在聚亚胺的存在下对α-氧化铝氢氧化物颗粒进行造粒来制备附聚物，以形成聚亚胺分散在其中的聚集体，然后使聚亚胺与二醛或环氧化合物反应。 优选的酶是葡萄糖异构酶。

公开(公告)号：US5091064A

公开(公告)日：1992-02-25

申请号：US572550

申请日：1990-08-27

申请人： Hasso Meinert ,  Rudolf Fackler ,  Juergen Mader ,  Peter Reuter

发明人： Hasso Meinert ,  Rudolf Fackler ,  Juergen Mader ,  Peter Reuter

IPC分类号： A61K9/00 ,  A61K9/08 ,  C07D207/10 ,  C07D211/38 ,  C07D265/30 ,  C07D403/06 ,  C25B3/08

CPC分类号： A61K9/0026 ,  C07D207/10 ,  C07D211/38 ,  C07D265/30 ,  C07D403/06 ,  C25B3/08

摘要： A method for preparing perfluorinated heterocyclic compounds corresponding to the formulas Ia and Ib ##STR1## wherein m represents 3 or 4, andx is a --CF.sub.2 --O--CF.sub.2 -- group, a --CF.sub.2 --CF.sub.2 --CF.sub.2 -- group, or a --CF(CF.sub.3)--CF.sub.2 -- group,and their mixtures, and the perfluoro-N-cyclohexylmorpholine prepared by this method. The compounds are obtained by electrochemical perfluorination starting from corresponding cycloalkenyl derivatives, and they can be used for preparing medically usable aqueous emulsions, e.g. blood substitutes.

摘要翻译： 一种制备对应于式Ia和Ib的全氟化杂环化合物的方法，其中m表示3或4，x是-CF 2 -O-CF 2 - 基，-CF 2 -CF 2 -CF2-基或 - CF（CF 3）-CF 2 - 基团及其混合物，以及通过该方法制备的全氟-N-环己基吗啉。 化合物通过电化学全氟化从相应的环烯基衍生物开始获得，并且它们可用于制备医学上可用的水性乳液，例如， 血液替代品

公开(公告)号：US5009071A

公开(公告)日：1991-04-23

申请号：US421051

申请日：1989-10-13

申请人： Norbert Schwetje ,  Rudolf Sizmann ,  Noureddine Khelifa

发明人： Norbert Schwetje ,  Rudolf Sizmann ,  Noureddine Khelifa

IPC分类号： F25B15/00 ,  B01D53/26 ,  C09K5/00 ,  C09K5/04 ,  C09K5/08 ,  F24F3/14 ,  F24F5/00

CPC分类号： C09K5/047 ,  F24F3/1417 ,  F24F5/00

摘要： In a process for adsorption cooling/conditioning of rooms, working media are used which comprise saturated aqueous solutions of calcium salts with an added organic polyhydroxy compound. The working media are distinguished by high salt contents and low salt precipitation temperatures at very low water vapor partial pressures and are suitable for use in continuously operated adsorption/desorption cycles of adsorption cooling/conditioning systems having high coefficients of performance.

摘要翻译： 在房间的吸附冷却/调节过程中，使用包含饱和的钙盐水溶液与加入的有机多羟基化合物的工作介质。 工作介质的特点是高盐含量和低盐沉淀温度在非常低的水蒸气分压下，适用于具有高性能系数的吸附冷却/调节系统的连续操作吸附/解吸循环。

公开(公告)号：US4922041A

公开(公告)日：1990-05-01

申请号：US195797

申请日：1988-05-19

申请人： Dieter Naumann ,  Wieland Tyrra ,  Birgit Kock ,  Werner Rudolph ,  Bernd Wilkes

发明人： Dieter Naumann ,  Wieland Tyrra ,  Birgit Kock ,  Werner Rudolph ,  Bernd Wilkes

IPC分类号： C07C17/20 ,  C07C17/00 ,  C07C17/093 ,  C07C19/08 ,  C07C19/16 ,  C07C67/00 ,  C07F3/06 ,  C25B3/12

CPC分类号： C07F3/06 ,  C07C17/093

摘要： A method for producing trifluoroiodomethane in which a metal Mt selected from the group magnesium, zinc, cadmium, bismuth and tin is reacted in a first step (a) with a trifluorohalomethane, and the resulting reaction mixture is further reacted in a second step (b) with a component containing iodine to produce CF.sub.3 I. Compounds corresponding to the formula CF.sub.3.Zn.X.nL are also described.

摘要翻译： 一种制备三氟碘甲烷的方法，其中选自镁，锌，镉，铋和锡之中的金属Mt在第一步骤（a）中与三氟卤代甲烷反应，并将所得反应混合物在第二步（b ）与含有碘的成分产生CF 3 I。 还描述了对应于式CF3.Zn.X.nL的化合物。

公开(公告)号：US4595531A

公开(公告)日：1986-06-17

申请号：US602279

申请日：1984-04-24

申请人： Wolfgang Milkowski ,  Renke Budden ,  Siegfried Funke ,  Rolf Huschens ,  Hans-Gunther Liepmann ,  Werner Stuhmer ,  Horst Zeugner

发明人： Wolfgang Milkowski ,  Renke Budden ,  Siegfried Funke ,  Rolf Huschens ,  Hans-Gunther Liepmann ,  Werner Stuhmer ,  Horst Zeugner

IPC分类号： C07D317/66 ,  A61K31/395 ,  A61K31/55 ,  A61K31/551 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C233/12 ,  C07C233/78 ,  C07C235/50 ,  C07D20060101 ,  C07D243/14 ,  C07D243/16 ,  C07D243/28 ,  C07D245/06 ,  C07D319/18 ,  C07D403/06 ,  C07D405/02 ,  C07D491/04 ,  C07D491/056 ,  C07D401/06 ,  C07D413/06

CPC分类号： A61K31/395 ,  C07C233/12 ,  C07D245/06 ,  C07D491/04

摘要： Benzodiazocines corresponding to the formula ##STR1## are converted to benzodiazepines corresponding to the formula ##STR2## of claim 1 by subjecting the benzodiazocine (a) if it is halogen-substituted in the 3-position to a thermal treatment which may also take place in the presence of a nucleophilic agent for the reaction or (b) if the 3-position is hydroxy substituted to treatment with a Lewis acid which is a chlorinating or brominating agent. Whenever the diazepine obtained as the final product has a 2-halogenomethyl group it may then be converted to benzodiazepine which is otherwise substituted in the 2-position.

摘要翻译： 对应于式“IMAGE”的苯并二氮杂环己酮转化为对应于权利要求1的式“苯并二氮杂”，其通过使苯并二氮嗪（a）在3-位上被卤素取代进行热处理，所述热处理也可能发生在 用于反应的亲核剂的存在或（b）如果3-位被羟基取代，则用作为氯化或溴化剂的路易斯酸处理。 每当作为最终产物得到的二氮杂具有2-卤代甲基时，其可以转化为苯并二氮杂，其另外被取代在2-位。

公开(公告)号：US4432943A

公开(公告)日：1984-02-21

申请号：US578712

申请日：1975-05-19

申请人： Reimar Musall ,  Wilhelm Wolsing

发明人： Reimar Musall ,  Wilhelm Wolsing

IPC分类号： B01J19/24 ,  B01J35/02 ,  F01N3/28 ,  F01N13/14 ,  F01N3/15 ,  B01J8/02

CPC分类号： F01N3/2864 ,  B01J35/02 ,  F01N3/2853 ,  F01N3/2867 ,  F01N13/14 ,  F01N2260/18 ,  F01N2310/02 ,  F01N2330/06 ,  F01N2350/04 ,  F01N2350/06

摘要： A catalyzer for detoxifying exhaust gases from an internal combustion engine wherein a monolithic catalyst body is supported within a housing having a composite damping arrangement placed in the housing between the catalyst body and the housing walls and having a portion extending axially of the catalyst body for damping radial forces acting on the body, and end portions for damping axial forces acting on the catalyst body, means cooperating with the damping means for elastically suspending the catalyst body in the housing and protecting rings positioned between the elastic holder and the catalyst body to further protect the edges of the catalyst body against destructive forces thereon.

摘要翻译： 一种用于对来自内燃机的废气进行解毒的催化剂，其中单体催化剂体被支撑在具有复合阻尼装置的壳体内，所述复合阻尼装置放置在壳体内的催化剂体和壳体壁之间，并且具有沿催化剂体轴向延伸的部分用于阻尼 作用在本体上的径向力和用于阻止作用在催化剂体上的轴向力的端部，与阻尼装置配合的装置，用于将催化剂体弹性悬挂在壳体中，并且保护环位于弹性保持架和催化剂体之间，以进一步保护 催化剂体的边缘抵抗其上的破坏力。

公开(公告)号：US4248847A

公开(公告)日：1981-02-03

申请号：US876050

申请日：1978-02-08

申请人： Helmut Derleth ,  Ludwig Walter ,  Karl-Heinrich Bretz ,  Artur Kurs

发明人： Helmut Derleth ,  Ludwig Walter ,  Karl-Heinrich Bretz ,  Artur Kurs

IPC分类号： C11D3/12 ,  C01B20060101 ,  C01B25/28 ,  C01B39/02 ,  C01B39/16 ,  F16G13/00 ,  C01B33/28

CPC分类号： C01B33/2823 ,  Y10S423/24

摘要： A process for preparing a synthetic substantially crystalline sodium aluminosilicate of the zeolite A type is disclosed. The process comprises rapidly and simultaneously introducing a sodium silicate and a sodium aluminate solution under thorough agitation at a constant by volume ratio which provides for a reaction mixture the content of which is equivalent to a molar ratio of x' Na.sub.2 O/ 1 Al.sub.2 O.sub.3 / y SiO.sub.2 /z' H.sub.2 O wherein x' is from about 6.5 to about 9.0, y is from about 1.7 to about 2.2 and z' is from about 180 to about 250, maintaining the reaction mixture at a temperature of from about 70.degree. to about 100.degree. C. under stirring for a sufficient period of time, usually 1-3 hours, in order to allow the initially amorphous reaction product to crystallize and recovering the substantially crystalline product from the resulting suspension. The essential feature of the process is a continuously maintained constant molar ratio Na.sub.2 O/ Al.sub.2 O/ SiO.sub.2 /H.sub.2 O throughout the reaction mixture during the entire course of the process. The resulting product exhibits a small particle size, an excellent wettability and a high calcium binding power, and is especially suited as a detergent additive.

摘要翻译： 公开了一种制备沸石A型合成基本上结晶的硅铝酸钠的方法。 该方法包括快速并同时在体积比不变的充分搅拌下引入硅酸钠和铝酸钠溶液，其提供反应混合物，其含量相当于x'Na 2 O / 1 Al 2 O 3 / y SiO 2的摩尔比 / z'H 2 O，其中x'为约6.5至约9.0，y为约1.7至约2.2，z'为约180至约250，将反应混合物保持在约70℃至约100℃的温度 在搅拌下足够的时间，通常为1-3小时，以使最初的无定形反应产物从所得悬浮液中结晶并回收基本上结晶的产物。 该方法的基本特征是在整个过程中在整个反应混合物中持续恒定的摩尔比Na 2 O / Al 2 O / SiO 2 / H 2 O。 所得产品具有小的粒度，优异的润湿性和高的钙结合力，并且特别适合作为洗涤剂添加剂。

公开(公告)号：US4222967A

公开(公告)日：1980-09-16

申请号：US810565

申请日：1977-06-27

申请人： Horst Boehm ,  Karl-Heinz Hellberg

发明人： Horst Boehm ,  Karl-Heinz Hellberg

IPC分类号： B01J21/00 ,  B01J21/04 ,  B01J21/06 ,  B01J21/12 ,  B01J21/18 ,  B01J27/00 ,  B01J27/06 ,  B01J27/08 ,  B01J27/122 ,  B01J27/125 ,  B01J27/132 ,  B01J27/135 ,  B01J27/138 ,  C07B61/00 ,  C07C17/00 ,  C07C17/20 ,  C07C19/14 ,  C07C67/00 ,  C07C17/10

CPC分类号： C07C17/206 ,  Y02P20/582

摘要： A process for brominating fluorine- and chlorine-containing halogenated hydrocarbons of formula (I) ##STR1## wherein R.sub.1 represents hydrogen, fluorine, chlorine, bromine, lower alkyl, or at least partially fluorinated lower alkyl; R.sub.2 represents hydrogen, fluorine, chlorine, or bromine; and, R.sub.3 represents fluorine or perfluorinated lower alkyl, to form the corresponding compounds of formula (II) ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined above is disclosed. According to this process, compounds of formula (I) are reacted in gaseous form at relatively mild reaction conditions, e.g., reaction temperatures of between 100.degree.-500.degree. C. with hydrogen bromide in the presence of a catalyst comprising at least one component selected from the group consisting of(a) active carbon,(b) silica gel,(c) active alumina, and(d) a bromide of an element selected from the group consisting of Li, Na, K, Rb, Cs, Mg, Ca, Sr, Ba, Zn, Cd, Cu, Ag, Al, Tl(I), Pb, Cr, Mn, Fe, Co, Ni, rare earth metals and metals of the platinum group.

摘要翻译： 用于溴化含有式（I）的含氟和氯的卤代烃的方法其中R 1表示氢，氟，氯，溴，低级烷基或至少部分氟化的低级烷基; R2代表氢，氟，氯或溴; 并且R 3表示氟或全氟化低级烷基，以形成相应的式（II）化合物。其中R 1，R 2和R 3如上定义。 根据该方法，式（I）化合物在相对温和的反应条件下以气态形式反应，例如在含有选自至少一种成分的催化剂存在下，在100-500℃之间的反应温度与溴化氢反应 由（a）活性炭，（b）硅胶，（c）活性氧化铝组成的组和（d）选自Li，Na，K，Rb，Cs，Mg， Ca，Sr，Ba，Zn，Cd，Cu，Ag，Al，Tl（I），Pb，Cr，Mn，Fe，Co，Ni，稀土金属和铂族金属。

公开(公告)号：US3945803A

公开(公告)日：1976-03-23

申请号：US347559

申请日：1973-04-03

申请人： Reimar Musall ,  Wilhelm Wolsing ,  Klaus Almeroth

发明人： Reimar Musall ,  Wilhelm Wolsing ,  Klaus Almeroth

IPC分类号： B01J19/24 ,  F01N3/28 ,  B01J8/00 ,  F01N3/15

CPC分类号： F01N3/2853 ,  F01N3/2867 ,  F01N3/2875 ,  F01N2330/06 ,  F01N2470/12

摘要： In an apparatus for cleaning exhaust gases comprising a rigid housing forming an outer wall of the exhaust conduit, a pocket formed at each end of the housing, a pair of accordion-shaped or corrugated wall and resilient compensating devices placed at each end into the pockets and each having gripping end portions, a catalyzer body of the monolithic type being placed between the gripping end portions for suspension axially within the housing with a gap in the housing.

摘要翻译： 在用于清洁废气的装置中，包括形成排气导管的外壁的刚性壳体，形成在壳体每端的一个口袋，一对折叠式波纹壁和弹性补偿装置，每个端部放置在口袋内 并且每个具有夹持端部，整体式催化剂主体被放置在夹持端部之间，用于在壳体内轴向悬挂，并且在壳体中具有间隙。