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1.发明申请公开(公告)号：US20160206632A1
公开(公告)日：2016-07-21
申请号：US15082098
申请日：2016-03-28
申请人： Robert D. Kross
发明人： Robert D. Kross
IPC分类号： A61K31/60 , A61K31/192 , A61K9/08 , A61K33/00 , A61K9/00
CPC分类号： A61K31/60 , A61K9/0014 , A61K9/08 , A61K31/19 , A61K31/192 , A61K31/194 , A61K33/00 , A61K47/38 , A61K2300/00
摘要： A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an α-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The α-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof. The alkaline nitrite salt is preferably sodium nitrite. The acidic part and the alkaline part are an acidic aqueous solution and an alkaline aqueous solution, respectively, which may either be mixed with one another then applied to an affected portion of a patient's skin or, alternatively, may be sequentially applied to the affected portion of the patient's skin, preferably within 15 minutes of one another.
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2.发明申请公开(公告)号：US20180055857A1
公开(公告)日：2018-03-01
申请号：US15558882
申请日：2016-03-16
发明人： Robert D. KROSS
IPC分类号： A61K31/60 , A61K31/192 , A61K9/00 , A61K9/08
CPC分类号： A61K31/60 , A61K9/0014 , A61K9/08 , A61K31/192 , A61K33/00 , A61K33/14 , A61K2300/00
摘要： A method for treating skin conditions of a patient, including acne vulgaris, includes the steps of formulating an acidic aqueous solution having no less than a 0.1% concentration of mandelic acid and up to and including a 2.0% concentration of salicylic acid, formulating an alkaline aqueous solution having an alkaline nitrite salt as a first alkaline salt and a second alkaline salt of an acid selected from the anion of chlorous acid, fumaric acid, mandelic acid and a combination thereof. Thereafter, sequentially applying the acidic aqueous solution directly to the afflicted portion of the skin of the patient and, at least five minutes later, but no more than ten minutes later, applying the alkaline aqueous solution to that portion of the patient to which the acidic aqueous solution has already been applied.
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3.发明授权公开(公告)号：US09662341B2
公开(公告)日：2017-05-30
申请号：US15082098
申请日：2016-03-28
发明人： Robert D. Kross
IPC分类号： A61K31/19 , A61K31/60 , A61K9/08 , C01B21/50 , A61K33/00 , A61K31/192 , A61K31/194 , A61K9/00 , A61K47/38
CPC分类号： A61K31/60 , A61K9/0014 , A61K9/08 , A61K31/19 , A61K31/192 , A61K31/194 , A61K33/00 , A61K47/38 , A61K2300/00
摘要： A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an α-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The α-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof. The alkaline nitrite salt is preferably sodium nitrite. The acidic part and the alkaline part are an acidic aqueous solution and an alkaline aqueous solution, respectively, which may either be mixed with one another then applied to an affected portion of a patient's skin or, alternatively, may be sequentially applied to the affected portion of the patient's skin, preferably within 15 minutes of one another.
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4.发明授权公开(公告)号：US09295681B2
公开(公告)日：2016-03-29
申请号：US14564201
申请日：2014-12-09
发明人： Robert D. Kross
IPC分类号： A61K33/00 , A61K31/60 , A61K31/192 , A61K31/19 , A61K31/194 , A61K9/00 , A61K9/08 , A61K47/38
CPC分类号： A61K31/60 , A61K9/0014 , A61K9/08 , A61K31/19 , A61K31/192 , A61K31/194 , A61K33/00 , A61K47/38 , A61K2300/00
摘要： A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an α-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The α-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof. The alkaline nitrite salt is preferably sodium nitrite. The acidic part and the alkaline part are an acidic aqueous solution and an alkaline aqueous solution, respectively, which may either be mixed with one another then applied to an affected portion of a patient's skin or, alternatively, may be sequentially applied to the affected portion of the patient's skin, preferably within 15 minutes of one another.
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