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公开(公告)号：US20230140054A1
公开(公告)日：2023-05-04
申请号：US17792298
申请日：2021-01-17
申请人： Lupin Limited
发明人： Rajender Kumar KAMBOJ , Kamlesh Jyotindra PADIYA , Kamalakannan PRABAKARAN , Kumar Ram NAIK , Bhavani Shankar RAJESH , Ganpati Powar RAJENDRA , Subhash Ingawale SACHIN , Dattatray Karche AMIT , Shankar Dange SANTOSHKUMAR , Barve SITARAM RAMBHAU
IPC分类号： C07D311/58
摘要： This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.
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公开(公告)号：US20230025246A1
公开(公告)日：2023-01-26
申请号：US17778282
申请日：2020-11-18
申请人： LUPIN LIMITED
发明人： Rajender Kumar KAMBOJ , Shaji George KOCHUMALAYIL , Spinvin VENUGOPAL , Kamlesh Jyotindra PADIYA , Prabakaran KAMALAKANNAN , Kumar Ram NAIK , Sachin Subhash INGAWALE , Bhavani Shankar RAJESH , Rajendra Ganpati POWAR
IPC分类号： C07D311/58
摘要： A process for manufacturing substituted chroman compounds in an economically scalable manner, without the use of pyrophoric reagents. Also disclosed herein are chroman compound synthesis routes that do not include column chromatography purification steps. The disclosure also relates to the intermediates used in the synthesis. In particular, the disclosure relates to the synthesis of the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts thereof.
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公开(公告)号：US20220267339A1
公开(公告)日：2022-08-25
申请号：US17738370
申请日：2022-05-06
申请人： LUPIN LIMITED
发明人： Prathap Sreedharan Nair , Ganesh Bhausaheb Gudade , Sachin Sethi , Dipak Raychand Lagad , Chetan Sanjay Pawar , Mahadeo Bhaskar Tryambake , Chaitanya Prabhakar Kulkarni , Anil Kashiram Hajare , Balasaheb Arjun Gore , Sanjeev Anant Kulkarni , Milind Dattatraya Sindkhedkar , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： C07D487/04 , A61P35/00 , C07D471/04 , C07D519/00
摘要： The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.
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公开(公告)号：US20200375959A1
公开(公告)日：2020-12-03
申请号：US16868307
申请日：2020-05-06
申请人： Lupin Limited
IPC分类号： A61K31/437 , A61K9/10 , A61K9/20 , A61K47/32 , A61K47/10
摘要： A solid dispersion of rifaximin comprising rifaximin and pharmaceutically acceptable carrier. A pharmaceutical composition comprising the solid dispersion of rifaximin.
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公开(公告)号：US10292981B2
公开(公告)日：2019-05-21
申请号：US15642899
申请日：2017-07-06
申请人： LUPIN LIMITED
发明人： Nageswara Rao Irlapati , Gokul Keruji Deshmukh , Vijay Pandurang Karche , Santosh Madhukar Jachak , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： C07D271/113 , A61K31/4245 , A61P11/06 , A61K31/497 , C07D261/12 , C07D413/10 , C07D413/14 , C07D417/14 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/433 , A61K31/4439 , A61K31/496
摘要： The present invention relates to compounds of Formula (I), along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I).
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公开(公告)号：US20190110994A1
公开(公告)日：2019-04-18
申请号：US16089898
申请日：2017-03-30
申请人： LUPIN LIMITED
发明人： Chandrakant SHERVI , Byomakesh PANDA , Murali Krishna BHAVARISETTI , Subhasis DAS , Vijaya Kumar THOMMANDRU
IPC分类号： A61K9/20 , A61K31/7034 , A61K9/28
摘要： Present invention discloses the stable pharmaceutical composition comprising premix of dapagliflozin with at least one pharmaceutically acceptable excipient(s) and process for preparation thereof. Dapagliflozin is highly hygroscopic and hence it is difficult to formulate dapagliflozin as stable pharmaceutical composition. Present invention discloses the stable pharmaceutical composition of dapagliflozin comprising premix of dapagliflozin with lactose.
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公开(公告)号：US20190029968A1
公开(公告)日：2019-01-31
申请号：US16146237
申请日：2018-09-28
申请人： LUPIN LIMITED
IPC分类号： A61K9/50 , A61K47/38 , A61K47/32 , A61K9/20 , A61K31/165
摘要： The present invention provides a modified release formulation of lacosamide. The modified release formulation of the present invention comprising lacosamide and modified release polymer provides modified release of lacosamide with minimal Cmax to Cmin peak to trough variation over a period of at least 12 hrs.
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公开(公告)号：US20180273481A1
公开(公告)日：2018-09-27
申请号：US15947422
申请日：2018-04-06
申请人： LUPIN LIMITED
IPC分类号： C07D215/14
CPC分类号： C07D215/14 , C07B2200/13
摘要： The present invention is directed to polymorphic forms of Pitavastatin sodium and processes for preparation of the same.
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公开(公告)号：US20180236030A1
公开(公告)日：2018-08-23
申请号：US15959650
申请日：2018-04-23
申请人： LUPIN LIMITED
IPC分类号： A61K38/17 , C07K14/715 , C07K19/00 , A61K9/19 , A61K9/00
CPC分类号： A61K38/1793 , A61K9/0019 , A61K9/19 , C07K14/715 , C07K19/00 , C07K2319/30
摘要： The present invention relates to the stable pharmaceutical compositions comprising tumor necrosis factor receptor Fc fusion protein (TNFR:Fc). More particularly, it relates to the stable pharmaceutical compositions comprising tumor necrosis factor receptor Fc fusion protein (TNFR:Fc), phosphate-citrate buffer. It also relates to the methods of manufacturing the composition, method of administration and kits containing the same.
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公开(公告)号：US09969731B2
公开(公告)日：2018-05-15
申请号：US15388327
申请日：2016-12-22
申请人： LUPIN LIMITED
发明人： Bhavesh Dave , Rakesh Kumar Banerjee , Samiron Phukan , Abhijit Datta Khoje , Rajkumar Hangarge , Jitendra Sambhaji Jadhav , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： C07D471/04 , A61K45/06 , A61K31/519 , A61K31/5377 , A61K31/541
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , A61N5/10
摘要： The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below:
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