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1.发明申请公开(公告)号：US20180251430A1
公开(公告)日：2018-09-06
申请号：US15757177
申请日：2016-09-01
IPC分类号： C07D231/12
CPC分类号： C07D231/12 , C07B2200/13 , C07D403/12
摘要： The present invention relates to 1-(4-(2-((1-(3,4-difluorophenyl)-1 H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone salts, specifically to the hydrochloride and to the maleate, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of sigma receptor associated diseases.
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公开(公告)号：US09789130B2
公开(公告)日：2017-10-17
申请号：US14366839
申请日：2012-12-17
IPC分类号： A61K31/702 , A61K31/7028 , A61K31/7016 , G01N33/569 , A61K39/21 , A61K8/14 , C07K16/28 , A61K8/60 , A61K8/68 , A61K39/00
CPC分类号： A61K31/7028 , A61K8/14 , A61K8/602 , A61K8/68 , A61K31/7016 , A61K39/21 , A61K2039/5154 , C07K16/2803 , C12N2740/16034 , C12N2740/16061 , G01N33/56988 , G01N2333/16 , Y02A50/386 , Y02A50/388
摘要： The present invention refers to methods and compositions to prevent viral entry into cells expressing the CD169/sialoadhesin surface receptor by inhibiting the coupling of the sialyllactose molecule contained in the viral membrane gangliosides to the CD 169/sialoadhesin receptor. The invention also pertains to vaccine compositions based on dendritic cells loaded with an antigen of interest whereby the vaccine is provided together with a composition capable of preventing viral entry into cells expressing the CD169/sialoadhesin. Moreover, the invention relates to diagnostic and therapeutic compositions that can be specifically delivered to enveloped virions wherein the diagnostic/therapeutic agent is coupled to CD169/sialoadhesin.
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公开(公告)号：US09518015B2
公开(公告)日：2016-12-13
申请号：US14345136
申请日：2012-09-14
申请人： Antoni Torrens Jover , Ramon Mercè Vidal , Francesc Xavier Caldentey Frontera , Antonio David Rodríguez Garrido , Elena Carceller González , Jordi Salas Solana
发明人： Antoni Torrens Jover , Ramon Mercè Vidal , Francesc Xavier Caldentey Frontera , Antonio David Rodríguez Garrido , Elena Carceller González , Jordi Salas Solana
IPC分类号： C07D209/12 , C07D209/34 , C07D405/06 , C07D209/42 , C07D215/48 , C07D235/06 , C07D471/04 , C07D209/08 , C07D231/56 , C07D401/06 , C07D405/12 , C07D241/42 , C07D487/04 , C07D265/36
CPC分类号： C07D209/42 , C07D209/08 , C07D209/12 , C07D209/34 , C07D215/48 , C07D231/56 , C07D235/06 , C07D241/42 , C07D265/36 , C07D401/06 , C07D405/06 , C07D405/12 , C07D471/04 , C07D487/04
摘要： The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.
摘要翻译： 本发明属于EP1受体配体领域。 更具体地，其是指对EP1受体具有很大亲和力和选择性的通式（I）的化合物。 本发明还涉及其制备方法，用作药物用于治疗和/或预防由EP1受体介导的疾病或病症以及包含它们的药物组合物。
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![Substituted pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma receptors ligands](/abs-image/US/2016/03/08/US09278974B2/abs.jpg.150x150.jpg)
4.发明授权Substituted pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma receptors ligands 有权取代的吡唑并[3,4-d]嘧啶化合物，其制备和用作σ受体配体公开(公告)号：US09278974B2
公开(公告)日：2016-03-08
申请号：US14442816
申请日：2013-11-14
IPC分类号： C07D293/06 , C07H21/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to new substituted pyrazolo[3,4-d]pyrimidine compounds, having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
摘要翻译： 本发明涉及对σ受体，特别是σ-1受体以及其制备方法对包含它们的组合物具有很大亲和性的新的取代的吡唑并[3,4-d]嘧啶化合物， 用作药物。
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公开(公告)号：US20150196504A1
公开(公告)日：2015-07-16
申请号：US14665060
申请日：2015-03-23
IPC分类号： A61K31/135 , A61K31/635
CPC分类号： A61K31/635 , A61K9/16 , A61K31/135 , A61K31/137 , A61K31/192 , A61K45/06 , C07B2200/13 , C07C59/64 , C07C217/74 , C07C2601/14 , C07D231/12 , A61K2300/00
摘要： The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
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公开(公告)号：US20150164920A1
公开(公告)日：2015-06-18
申请号：US14388308
申请日：2013-03-27
IPC分类号： A61K31/606 , A61K9/28 , A61K9/50
CPC分类号： A61K31/606 , A61K9/2866 , A61K9/5015 , A61K9/5047
摘要： The present invention refers to a controlled release pharmaceutical formulation in solid form comprising Mesalamine. The invention also contemplates the preparation of the said formulation and its use for the treatment of patients suffering from inflammatory bowel disease (IBD).
摘要翻译： 本发明涉及包含Mesalamine的固体形式的控释药物制剂。 本发明还考虑了所述制剂的制备及其用于治疗患有炎症性肠病（IBD）的患者的用途。
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7.发明申请COMPOSITIONS COMPRISING TRAMADOL AND CELECOXIB IN THE TREATMENT OF PAIN 审中-公开包含TRAMADOL和CELECOXIB在治疗疼痛中的组合物公开(公告)号：US20150150889A1
公开(公告)日：2015-06-04
申请号：US14613475
申请日：2015-02-04
IPC分类号： A61K31/635 , A61K31/137
CPC分类号： A61K31/635 , A61K31/135 , A61K31/137 , A61K31/415 , A61K45/06 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.
摘要翻译： 本发明涉及包含曲马多和塞来昔布的药物组合物及其作为药物或止痛剂的用途，更具体地涉及用炎症组分治疗严重至中度疼痛。
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8.发明授权5-methyl-1-(naphthalen-2-yl)-1H-pyrazole derivatives and their use in potentiating the effect of opioid analgesics 有权5-甲基-1-（萘-2-基）-1H-吡唑衍生物及其用于增强阿片类镇痛药的作用公开(公告)号：US08729073B2
公开(公告)日：2014-05-20
申请号：US13991267
申请日：2011-12-02
IPC分类号： A61K31/535 , A61K31/44 , C07D265/30
CPC分类号： A61K31/535 , A61K31/485 , A61K31/5377 , C07D413/12
摘要： The invention relates to pyrazole derivatives of formula I having pharmacological activity and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of pain.
摘要翻译： 本发明涉及具有药理活性的式I的吡唑衍生物及其制备方法，包括它们的药物组合物，以及它们在治疗和/或预防疼痛中的用途。
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公开(公告)号：US20140107111A1
公开(公告)日：2014-04-17
申请号：US14118704
申请日：2012-05-18
IPC分类号： A61K31/541 , C07D231/22 , A61K31/415 , A61K31/4155 , C07D403/12 , C07D401/12 , A61K31/4178 , A61K31/4545 , C07D471/04 , A61K31/496 , A61K31/4725 , A61K31/5377 , A61K31/454
CPC分类号： A61K31/541 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D231/22 , C07D401/12 , C07D403/12 , C07D471/04 , A61K2300/00
摘要： The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat type-2 diabetes-associated pain and related symptoms.
摘要翻译： 本发明涉及使用Sigma配体，特别是式（I）的Sigma配体来预防和/或治疗2型糖尿病相关的疼痛和相关症状。
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公开(公告)号：US20140057879A1
公开(公告)日：2014-02-27
申请号：US14066127
申请日：2013-10-29
IPC分类号： A61K31/635 , A61K31/137
CPC分类号： A61K31/635 , A61K9/16 , A61K31/135 , A61K31/137 , A61K31/192 , A61K45/06 , C07B2200/13 , C07C59/64 , C07C217/74 , C07C2601/14 , C07D231/12 , A61K2300/00
摘要： The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
摘要翻译： 本发明涉及选自NSAIDs / coxibs的曲马多和共晶体形成剂的共晶体，其制备方法及其作为药物的用途或药物制剂，特别是用于治疗疼痛。
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