公开(公告)号：US20240294638A1

公开(公告)日：2024-09-05

申请号：US18661970

申请日：2024-05-13

申请人： LES LABORATOIRES SERVIER

发明人： Randi Westh Hansen ,  Franziska Katharina Uhlenbrock ,  Nikolaj Dietrich ,  Anne Worsaae ,  Michael Monrad Grandal

IPC分类号： C07K16/28 ,  A61K45/06 ,  A61P35/00

CPC分类号： C07K16/2803 ,  A61K45/06 ,  A61P35/00 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/76 ,  C07K2317/92

摘要： This invention relates to anti-NKG2A antibodies and methods of using them in enhancing immunity in a patient in need thereof and in treating cancer.

公开(公告)号：US12030942B2

公开(公告)日：2024-07-09

申请号：US17324508

申请日：2021-05-19

申请人： Les Laboratoires Servier

发明人： Gunther Galler ,  Monika Gad ,  Klaus Koefoed ,  Ivan D. Horak ,  Thomas Bouquin ,  Michael Kragh ,  Mikkel Pedersen

IPC分类号： C07K16/28 ,  A61K45/06 ,  A61P35/00 ,  A61K39/00

CPC分类号： C07K16/2818 ,  A61K45/06 ,  A61P35/00 ,  A61K2039/505

摘要： This invention relates to anti-PD-1 antibodies and methods of using them in treating diseases and conditions related to PD-1 activity, e.g., cancer.

公开(公告)号：US20230270748A1

公开(公告)日：2023-08-31

申请号：US18007321

申请日：2021-07-30

申请人： LES LABORATOIRES SERVIER ,  NOVARTIS AG

发明人： Emmelyne DESSEIN ,  Lisa MAHNKE ,  Michael Robert COOPER

IPC分类号： A61K31/5377 ,  A61K31/706

CPC分类号： A61K31/5377 ,  A61K31/706

摘要： A combination comprising a Bcl-2 inhibitor with a hypomethylating agent, uses in the treatment of cancers and pharmaceutical compositions thereof. The Bcl-2 inhibitor is 5-(5-chloro-2-{[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-N-(5-cyano-1,2-dimethyl-1H-pyrrol-3-yl)-N-(4-hydroxyphenyl)-1,2-dimethyl-1H-pyrrole-3-carboxamide and the hypomethylating agent is selected from decitabine, azacitidine and guadecitabine.

公开(公告)号：US20230092679A1

公开(公告)日：2023-03-23

申请号：US17613006

申请日：2020-05-19

申请人： NOVARTIS AG ,  LES LABORATOIRES SERVIER

发明人： Matthew T. Burger ,  Maia Chanrion ,  Frédéric Colland ,  Marton Csekei ,  Lea Delacour ,  Patrice Desos ,  Olivier Geneste ,  Jean-Michel Henlin ,  Vesela Kostova ,  Andras Kotschy ,  Ana Leticia Maragno ,  Eric McNeill ,  Mark G. Palermo ,  Francesca Rocchetti ,  Jérôme Starck ,  Bing Yu ,  Qiang Zhang ,  Ágnes Proszenyák ,  Szabolcs Sipos ,  Zhuoliang Chen ,  Katsumasa Nakajima ,  Joseph Anthony D'Alessio

IPC分类号： A61K47/68 ,  A61K47/65 ,  A61K31/505 ,  A61P35/00

摘要： Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.

公开(公告)号：US20220203260A1

公开(公告)日：2022-06-30

申请号：US17429600

申请日：2020-02-04

申请人： LES LABORATOIRES SERVIER

发明人： Jean-Baptiste Gandar ,  Christophe Besseyre ,  Bruno Aubry ,  Samuel Lapert

IPC分类号： B01D3/08 ,  B01D5/00

摘要： Disclosed is a removable containment device for a rotary evaporator, comprising: a first end (12) for sealed connection to a rotation shaft (3) of the rotary evaporator (1); a second end (13) for sealed connection to a container (2) for receiving a mixture to be evaporated; and a body (11) in fluid connection with the first and second sealed connection ends (12, 13) comprising a valve system (14) for the selective passage between the first and second ends (12, 13) of the evaporating constituent of the mixture to be evaporated.

公开(公告)号：US11299542B2

公开(公告)日：2022-04-12

申请号：US16456328

申请日：2019-06-28

申请人： Les Laboratoires Servier ,  Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Julie Pannequin ,  Laure Boudier ,  Dominique Joubert ,  Frédéric Hollande

IPC分类号： A61K39/00 ,  C07K16/26 ,  G01N33/574

摘要： The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.

公开(公告)号：US20220098203A1

公开(公告)日：2022-03-31

申请号：US17418406

申请日：2019-12-27

申请人： Les Laboratoires Servier SAS

发明人： Zenon D. KONTEATIS ,  Mingzong LI ,  Samuel K. REZNIK ,  Zhihua SUI ,  Jeremy M. TRAVINS

IPC分类号： C07D487/04 ,  C07D239/80 ,  C07D519/00 ,  C07D403/04 ,  C07D471/04 ,  A61P35/00

摘要： The present disclosure provides for compounds according to Formula I, Formula II, and their pharmaceutically acceptable salts, tautomers, and/or isotopologues as described in the disclosure. The compounds are inhibitors of methionine adenosyltransferase isoform 2A (MAT2A). Also provided are pharmaceutical compositions and methods of using the compounds for treating cancers, including some cancers in which the gene encoding methylthioadenosine phosphorylase (MTAP) is deleted.

公开(公告)号：US20210380549A1

公开(公告)日：2021-12-09

申请号：US17283107

申请日：2019-10-14

申请人： LES LABORATOIRES SERVIER

发明人： Louis-Philippe BEAUREGARD ,  Martial BERTRAND ,  Pascall GIGUERE ,  Christophe HARDOUIN ,  Bruno SCHIAVI

IPC分类号： C07D295/088

摘要： Process for the industrial synthesis of the compound of formula (I):

公开(公告)号：US20210355106A1

公开(公告)日：2021-11-18

申请号：US17282898

申请日：2019-10-18

申请人： LES LABORATOIRES SERVIER ,  VERNALIS (R&D) LTD

发明人： Csaba WÉBER ,  András KOTSCHY ,  Attila VASAS ,  Árpád KISS ,  Balázs MOLNÁR ,  Andrea FIUMANA ,  Alba MACIAS ,  James Brooke MURRAY ,  Didier DEMARLES ,  Lisa IVANSCHITZ ,  Olivier GENESTE ,  Kristóf HEGEDÜS ,  Péter SPRÁNITZ ,  Tibor SOÓS

IPC分类号： C07D401/14 ,  A61P35/00 ,  A61K45/06 ,  A61K31/513 ,  C07D417/14 ,  A61K31/517 ,  C07D409/14 ,  C07D405/14

摘要： wherein R1, R2, R3, R4, R5, n and Q are as defined in the description.

公开(公告)号：US20210309614A1

公开(公告)日：2021-10-07

申请号：US17141902

申请日：2021-01-05

申请人： GALAPAGOS NV ,  LES LABORATOIRES SERVIER

发明人： Franck Laurent BREBION ,  Luke Jonathan ALVEY ,  David AMANTINI ,  Frédéric André DE CEUNINCK ,  Pierre Marc Marie Joseph DEPREZ ,  Romain Luc Marie GOSMINI ,  Hélène Marie JARY ,  Christophe PEIXOTO ,  Iuliana Ecaterina POP-BOTEZ ,  Marie Laurence Claire VARIN

IPC分类号： C07D233/78 ,  C07D403/06 ,  A61P19/02 ,  A61P19/04 ,  A61K31/496 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D417/12 ,  A61K31/55

摘要： The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein.
The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.