公开(公告)号：US07927878B2

公开(公告)日：2011-04-19

申请号：US11628168

申请日：2005-06-01

申请人： Werner Kremer ,  Hans Robert Kalbitzer ,  Fritz Huber

发明人： Werner Kremer ,  Hans Robert Kalbitzer ,  Fritz Huber

IPC分类号： G01N33/92 ,  G01N24/08

CPC分类号： G01N24/08 ,  G01R33/4625 ,  G01R33/465 ,  Y10T436/24

摘要： The invention describes a process for the determination of the concentration distribution and size distribution of lipoprotein classes in body fluids, e.g. blood. For this purpose, NMR spectra of a sample to be analysed are measured by magnetic field gradient intensities and temperatures under different diffusion-weighted measuring conditions selected according to different pulse programs (e.g. PFG-STE, PFG-LED etc) and consequently in a differentiated manner according to the relaxation times. The different effects of these measuring conditions on the intensity/line form of the NMR signals of the individual lipoprotein classes are determined and permit the determination of a concentration distribution/size distribution of the individual lipoprotein classes.

摘要翻译： 本发明描述了用于测定体液中脂蛋白类别的浓度分布和尺寸分布的方法，例如， 血液。 为此，通过根据不同脉冲程序选择的不同扩散加权测量条件下的磁场梯度强度和温度来测量要分析的样品的NMR谱（例如PFG-STE，PFG-LED等），并因此分化 方式根据放松时间。 确定这些测量条件对各个脂蛋白类别的NMR信号的强度/线形式的不同影响，并且允许测定各个脂蛋白类别的浓度分布/尺寸分布。