公开(公告)号：US11938144B2

公开(公告)日：2024-03-26

申请号：US17970080

申请日：2022-10-20

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

CPC分类号： A61K31/724 ,  A61K9/0019 ,  A61K9/0085 ,  A61K9/08

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US20240016829A1

公开(公告)日：2024-01-18

申请号：US18141832

申请日：2023-05-01

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

CPC分类号： A61K31/724 ,  A61K9/08 ,  A61K9/0085 ,  A61K9/0019

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US11590160B2

公开(公告)日：2023-02-28

申请号：US17745497

申请日：2022-05-16

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US11510940B2

公开(公告)日：2022-11-29

申请号：US17745470

申请日：2022-05-16

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/08 ,  A61K9/00

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US20220273697A1

公开(公告)日：2022-09-01

申请号：US17745470

申请日：2022-05-16

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US11744850B2

公开(公告)日：2023-09-05

申请号：US18115901

申请日：2023-03-01

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

CPC分类号： A61K31/724 ,  A61K9/0019 ,  A61K9/0085 ,  A61K9/08

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US20230201247A1

公开(公告)日：2023-06-29

申请号：US18115897

申请日：2023-03-01

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

CPC分类号： A61K31/724 ,  A61K9/0019 ,  A61K9/0085 ,  A61K9/08

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US20230095371A1

公开(公告)日：2023-03-30

申请号：US18072260

申请日：2022-11-30

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US20220288106A1

公开(公告)日：2022-09-15

申请号：US17745516

申请日：2022-05-16

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US20220288105A1

公开(公告)日：2022-09-15

申请号：US17745481

申请日：2022-05-16

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.