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公开(公告)号：US20190023810A1
公开(公告)日：2019-01-24
申请号：US16065917
申请日：2016-12-28
发明人： Ram SASISEKHARAN , Kannan THARAKARAMAN , Vidya SUBRAMANIAN , Eduardo FLEISCHER , Andrew Peter HATAS
摘要： Described herein are mutations in the CHl/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
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2.发明申请公开(公告)号：US20190275520A1
公开(公告)日：2019-09-12
申请号：US16090582
申请日：2017-03-31
摘要： Methods and apparatus that facilitate membrane-perturbing surface interactions for delivering a payload to a variety of cell types without resulting in a substantial loss in cell viability or alteration of endogenous cellular functions. In one example, an intracellular delivery tool comprises a microfluidic device (10) which includes a microfluidic flow channel (12) containing fluid therein and a membrane perturbing surface (22), in fluid communication with the microfluidic flow channel (12), with a plurality of perturbing features disposed thereon. An exemplary intracellular delivery method includes flowing a fluid containing cells therein along a membrane perturbing surface having a plurality of perturbing features disposed thereon, and delivering nanomaterial across a membrane of the cells in the fluid during and after contact between the cells and the membrane perturbing surface.
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公开(公告)号：US20140287509A1
公开(公告)日：2014-09-25
申请号：US14352354
申请日：2012-10-17
IPC分类号： C12N5/071
摘要： A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
摘要翻译： 一种用于引起细胞膜中的扰动的微流体系统，该系统包括限定内腔的微流体通道，并且被配置为使得悬浮在缓冲液中的细胞可以通过其中，其中微流体通道包括细胞变形收缩部，其中直径 收缩是细胞直径的函数。
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4.发明公开公开(公告)号：US20240360569A1
公开(公告)日：2024-10-31
申请号：US18649438
申请日：2024-04-29
发明人： Yang Shao-Horn , Sunmoon Yu , Hiroki Yamauchi
IPC分类号： C25B3/07 , C25B3/26 , C25B11/048
CPC分类号： C25B3/07 , C25B3/26 , C25B11/048
摘要： Described is a method is to improve catalytic activity and selectivity for electrochemical CO2-to-methanol and CO-to-methanol conversions by employing acidic electrolyte cations that can facilitate proton transfer during the electrocatalytic conversion reactions.
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公开(公告)号：US20240352446A1
公开(公告)日：2024-10-24
申请号：US18685590
申请日：2022-08-23
发明人： Kevin Michael Esvelt , Boqiang Tu
IPC分类号： C12N15/10
CPC分类号： C12N15/1058 , C12N15/1068
摘要： The invention relates, in part, to methods and systems with which to combine methods of determining an activity of a gene of interest and the gene's sequence, thereby allowing the genotype and associated phenotype to be determined in a single sequencing step.
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公开(公告)号：US20240351225A1
公开(公告)日：2024-10-24
申请号：US18443618
申请日：2024-02-16
发明人： Haruhiko Asada , Kentaro Barhydt
摘要： Disclosed herein is a flexible robotic limb. The design may include a backbone with rolling-contact joints connected to one another by pulley structures and corresponding cord loops engaged with the pulley structures. One or more flexible actuators may be used to control a length between adjacent links of the rolling contact joints to control articulation of the flexible robotic limb while still permitting passive reconfiguration of the flexible robotic limb when it is not being actively articulated.
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公开(公告)号：US20240347995A1
公开(公告)日：2024-10-17
申请号：US18410142
申请日：2024-01-11
发明人： Harry Jay Levine , Dolev Bluvstein , Alexander Keesling-Contreras , Giulia Semeghini , Sepehr Ebadi , Tout Wang , Ahmed Omran , Mikhail Lukin , Markus Greiner , Vladan Vuletic
CPC分类号： H01S3/0057 , B82Y20/00 , G02B6/29394
摘要： A device for modulating an amplitude of a light beam, comprising a coherent light source configured to generate a phase-modulated beam having a plurality of frequency components; and a dispersive optical element. The dispersive optical element has a group delay dispersion and is configured to receive the phase-modulated beam, to introduce an optical phase shift to each of the plurality of the frequency components, so that the values of the optical phase shift vary non-linearly with frequency according to the group delay dispersion, and to recombine the plurality of frequency components, thereby generating an amplitude-modulated beam.
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公开(公告)号：US20240337541A1
公开(公告)日：2024-10-10
申请号：US18681295
申请日：2022-08-05
发明人： Erica SALAZAR , Zachary HARTWIG
IPC分类号： G01K11/3206 , G01K13/00
CPC分类号： G01K11/3206 , G01K13/006
摘要： A high temperature superconductor (HTS) cable includes at least one HTS tape stack extending along a length of the HTS cable; and at least one optical fiber extending along the HTS cable. The at least one optical fiber has a plurality of gratings spaced apart from one another along the length of the HTS cable to detect a quench of the at least one HTS tape stack.
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公开(公告)号：US20240336649A1
公开(公告)日：2024-10-10
申请号：US18572247
申请日：2022-06-17
发明人： ANDREI LOAS , BRADLEY L. PENTELUTE , SEBASTIAN POMPLUN , MUHAMMAD JBARA , CARLY KATHERINE SCHISSEL , JACOB JOSHUA LEE RODRIQUEZ , STEPHEN LEFFLER BUCHWALD , ANN BOIJA , ISAAC KLEIN , SUSANA WILSON HAWKEN , CHARLES HAN LI
CPC分类号： C07K1/10 , A61K49/0041 , A61K49/0056 , A61P35/00 , C07K1/063 , C07K1/1075 , C07K14/00 , A61K38/00
摘要： The disclosure relates to covalent protein dimers of MYC, MAX, and Omomyc; pharmaceutical compositions comprising the covalent protein dimers; methods of making the covalent protein dimers; and methods of treating disorders associated with MYC dysregulation (e.g., cancer) with the covalent protein dimers.
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公开(公告)号：US12111289B2
公开(公告)日：2024-10-08
申请号：US17255410
申请日：2019-06-26
CPC分类号： G01N29/0672 , G01N29/2418 , G01N33/12 , A61B5/0095 , A61B8/13 , G01N2291/02475
摘要： Systems and methods are provided for imaging of soft and hard tissues with ultrasound. Such systems and methods can provide for non-contact and quantitative ultrasound images of bone and soft tissue. A method for imaging a biological body segment of soft and hard tissues includes setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set. The method further includes collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set and minimizing a difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment. Regularizing travel-time and/or using full waveform tomographic techniques with level set methods enable recovery of cortical bone geometry.
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