公开(公告)号：US20230076090A1

公开(公告)日：2023-03-09

申请号：US17790330

申请日：2020-01-23

申请人： NOF CORPORATION

发明人： Masahiro TANAKA ,  Akihiro YAMADA ,  Tatsuya AONO ,  Kazuhiro ODA

IPC分类号： C07D317/36 ,  C08F220/28 ,  C08F222/10

摘要： (Object) When a cyclocarbonate group-containing (meth)acrylate monomer is applied for a polymer used as a paint or the like, it is to provide the cyclocarbonate group-containing (meth)acrylate monomer in which the increase of the viscosity over time is suppressed so that it can used stably for a long time. (Solution) It is provided a cyclocarbonate group-containing (meth)acrylate monomer (A) represented by a formula (1) as follows, wherein a content of di(meth)acrylate monomer (B) represented by a formula (2) as follows is 3 weight % or lower. (R1 represents hydrogen atom or methyl group, R2 represents an alkyl group having a number of carbons of 2 to 10, and X is 0 or 1.) (R3 represents hydrogen atom or methyl group, R4 represents an alkyl group having a number of carbons of 2 to 10, and X is 0 or 1.)

公开(公告)号：US20230056638A1

公开(公告)日：2023-02-23

申请号：US17789744

申请日：2021-01-12

申请人： NOF CORPORATION

发明人： Shunsuke MONJIYAMA ,  Hideki KAWAMOTO ,  Kazuhiro ODA

IPC分类号： C08F210/02 ,  B01J20/26 ,  C10G73/04

摘要： The dewaxing aid of the present invention is a dewaxing aid including an ethylene-α-olefin copolymer (A) having a molar ratio [(a)/(b)] of (a) ethylene and (b) an α-olefin having 3 or more and 12 or less carbon atoms of 93/7 to 75/25, and having a weight average molecular weight of 10,000 to 500,000. According to the present invention, a dewaxing aid that is excellent in improving filterability can be provided.

公开(公告)号：US11529423B2

公开(公告)日：2022-12-20

申请号：US16886056

申请日：2020-05-28

申请人： NOF CORPORATION

发明人： Takuma Tsubusaki ,  Yuji Yamamoto

IPC分类号： A61K47/60 ,  C08G65/333

摘要： A biodegradable polyethylene glycol derivative in which a polyethylene glycol chain is linked by an acetal linker capable of accurately controlling the hydrolysis rate under different pH environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body can be accurately controlled. The biodegradable polyethylene glycol derivative is represented by formula (1) or formula (2) as described.

公开(公告)号：US20220362397A1

公开(公告)日：2022-11-17

申请号：US17762719

申请日：2020-09-25

申请人： NOF CORPORATION

发明人： Yuki MATSUNO ,  Hiroki YOSHIOKA ,  Akira SUZUKI

IPC分类号： A61K47/68 ,  A61K47/60 ,  C07K5/06

摘要： A heterobifunctional monodisperse polyethylene glycol with two adjacent monodisperse polyethylene glycol side chains, in which a peptide linker is degraded by intracellular enzymes to release a drug slowly and effectively mask the hydrophobicity of the drug, and an antibody-drug conjugate in which the antibody and the drug are bound using same is provided. A heterobifunctional monodisperse polyethylene glycol represented by the formula (1): wherein each symbol in the formula (1) is as defined in the DESCRIPTION.

公开(公告)号：US20220339290A1

公开(公告)日：2022-10-27

申请号：US17763516

申请日：2020-09-25

申请人： NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

发明人： Ken Hamura ,  Hiroki Yoshioka ,  Kazuki Osakama ,  Nobuhiro Nishiyama

IPC分类号： A61K47/64 ,  A61K47/60

摘要： A branched degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A branched degradable polyethylene glycol derivative represented by the following formula (1), containing, in a molecule, an oligopeptide that is degraded in the cells: wherein k1 and k2 are each independently 1-12, j1 and j2 are each independently 45-950, R is a hydrogen atom, a substituted or unsubstituted alkyl group having 1-12 carbon atoms, a substituted aryl group, an aralkyl group or a heteroalkyl group, Z is an oligopeptide that is degraded by enzyme in the cells, X is a functional group capable of reacting with a bio-related substance, and L1 and L2 are each independently a single bond or a divalent spacer.

公开(公告)号：US20220213242A1

公开(公告)日：2022-07-07

申请号：US17606872

申请日：2020-07-07

申请人： NOF CORPORATION

发明人： Akihiro Yamada ,  Takeshi Yoshimura ,  Hiroyuki Ogi ,  Tatsuya Aono

IPC分类号： C08F212/08 ,  C08F212/10 ,  C08L91/06 ,  C08L25/14 ,  C08L25/06

摘要： An object is to provide a wax dispersant capable of improving the resin composition in the fluidity in a molten state, the transparency and the storage stability, when adding the wax to a thermoplastic resin. The wax dispersant is a copolymer (A) which has a copolymerization composition comprising structural units respectively derived from: an aromatic monomer (A1) within 40 to 94% by mass; a (meth)acrylic acid long chain alkyl ester (A2) represented by the formula (1) (an alcohol residue R2 is C9 to C22 alkyl) within 5 to 40% by mass; and a (meth)acrylic acid alkyl ester (A3) represented by the formula (2) (an alcohol residue R4 is C1 to C8 alkyl) within 1 to 20% by mass, and also has a weight average molecular weight within 3,000 to 50,000.

公开(公告)号：US20220154094A1

公开(公告)日：2022-05-19

申请号：US17439087

申请日：2020-03-10

申请人： NOF CORPORATION

发明人： Kazuhiro Oda ,  Yutaro Shimizu ,  Hideki Kawamoto

IPC分类号： C10M129/68 ,  C10M137/10 ,  C10M169/04 ,  C10M133/06

摘要： A lubricant additive includes a monoester carboxylic acid salt (A) represented by formula (1). In formula (1), R1 represents a single bond between carbon atoms of carbonyl groups, or a divalent hydrocarbon group having 1 to 4 carbon atoms, and R2 represents a hydrocarbon group having 1 to 22 carbon atoms. AO represents an oxyalkylene group of one type selected from oxyalkylene groups having 2 to 4 carbon atoms, or a mixed oxyalkylene group of two or more types selected from oxyalkylene groups having 2 to 4 carbon atoms, and n is an average number of added moles of the oxyalkylene group represented by AO and is 0 to 5. M represents organic ammonium.

公开(公告)号：US20210147624A1

公开(公告)日：2021-05-20

申请号：US17042711

申请日：2019-03-29

申请人： NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

发明人： Hiroki YOSHIOKA ,  Masaki KAMIYA ,  Yuji YAMAMOTO ,  Midori HIRAI ,  Akiko SASAKI ,  Nobuhiro NISHIYAMA ,  Makoto MATSUI ,  Hiroyasu TAKEMOTO ,  Kazuki MIYAUCHI ,  Takahiro NOMOTO ,  Keishiro TOMODA

IPC分类号： C08G65/333 ,  C08G65/325 ,  A61K47/65

摘要： The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.

公开(公告)号：US10995178B2

公开(公告)日：2021-05-04

申请号：US16324229

申请日：2017-08-04

申请人： NOF CORPORATION

发明人： Yusuke Hara ,  Kazuaki Wakita ,  Mitsushi Kusumoto ,  Megumi Nagayama ,  Shunsuke Monjiyama ,  Aiko Yamanaka ,  Hideki Kawamoto

IPC分类号： C08G65/08 ,  A61K8/86 ,  A61Q5/12 ,  C08G18/48 ,  C10M105/38 ,  C10M145/36 ,  C10M169/04 ,  C11D3/37

摘要： An alkyloxirane derivative represented by formula (1), wherein MH and ML calculated from a gel permeation chromatogram satisfy formula (2): Z—[O-(AO)n-H]x  (1) where Z represents a residual group of a compound having 1 to 22 carbon atoms and one to six hydroxyl groups and wherein all of the hydroxyl groups are excluded from said compound; x is 1 to 6; and AO represents an oxyalkylene group having 3 carbon atoms; and n is 25 or more; 0.35≤ML/MH≤0.75  (2) where MH represents a distance between point O and intersecting point P, and ML represents a distance between point Q and intersecting point P determined from the chromatogram.

公开(公告)号：US10947343B2

公开(公告)日：2021-03-16

申请号：US16492883

申请日：2018-03-22

申请人： NOF CORPORATION

发明人： Hiroki Yoshioka ,  Yuji Yamamoto

IPC分类号： C08G65/26 ,  C08G65/331 ,  A61K47/60

摘要： A method of producing a polyoxyethylene derivative (1): where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative.