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公开(公告)号：US20240085428A1
公开(公告)日：2024-03-14
申请号：US18268694
申请日：2021-12-20
IPC分类号： G01N33/574 , C07K16/32 , G01N33/68
CPC分类号： G01N33/57488 , C07K16/32 , G01N33/6887 , G01N2333/78
摘要： Disclosed herein are monoclonal antibodies that specifically recognise and bind to a C-terminus of a peptide that is the C-terminus neo-epitope formed on cleavage of the N-terminal pro-peptide of the α1-chain of type XI collagen at A′511↓, and immunoassay methods and kits using and containing the antibodies. The immunoassay methods may be used for detecting and/or monitoring and/or assessing the severity or prognosis of diseases, such as, but not limited to, cancer.
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公开(公告)号：US20230258658A1
公开(公告)日：2023-08-17
申请号：US17640819
申请日：2020-09-03
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/6893 , C07K2317/34 , G01N2333/78 , G01N2800/50 , G01N2800/56 , G01N2800/325
摘要： Disclosed herein are immunoassays, in particular immunoassays for detecting and/or monitoring cardiovascular disease, such as heart failure. Also disclosed are monoclonal antibodies and kits for use in said assays. The assays, antibodies and kits target a C-terminal epitope of type XXVIII collagen.
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公开(公告)号：US20220317133A1
公开(公告)日：2022-10-06
申请号：US17616296
申请日：2020-06-05
申请人： Nordic Bioscience A/S , Bristol-Myers Squibb Company , The Trustees of the University of Pennsylvania
发明人： Federica Genovese , Morten Karsdal , Lei Zhao , David Gordon , Zhaoqing Wang , Julio Alonso Chirinos Medina
IPC分类号： G01N33/68
摘要： A method of immunoassay for detecting and/or monitoring a cardiovascular disease in a patient and/or assessing the likelihood of or the severity of a cardiovascular disease in a patient, comprising contacting a biofluid sample from a patient with a monoclonal antibody that specifically binds to a C-terminal epitope of the C5 domain of the α3 chain of type VI collagen, and/or contacting a biofluid sample from the patient with a monoclonal antibody that specifically binds to a C-terminal neo-epitope of the N-terminal propeptide of type III collagen.
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公开(公告)号：US20220146528A1
公开(公告)日：2022-05-12
申请号：US17584517
申请日：2022-01-26
发明人： Yi He , Anne-Cecilie Bay-Jensen , Morten Karsdal
IPC分类号： G01N33/68 , G01N33/577 , C12N5/16 , C07K16/18
摘要： Provided herein is an antibody specifically reactive with an N-terminus neo-epitope of collagen type X alpha 1 in the amino acid sequence H2N-GIATKGLNGP, and its use in an immunoassay for evaluating a disease associated with collagen type X alpha 1, such as osteoarthritis.
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公开(公告)号：US20180267060A1
公开(公告)日：2018-09-20
申请号：US15994786
申请日：2018-05-31
IPC分类号： G01N33/68 , G01N33/577 , C07K16/40 , C07K16/18
CPC分类号： G01N33/6878 , C07K16/18 , C07K16/40 , C07K2317/33 , C07K2317/34 , G01N33/577 , G01N33/6893 , G01N2333/78 , G01N2333/96411 , G01N2333/96419 , G01N2800/122 , G01N2800/7052
摘要： A method of bioassay for the quantification of peptide fragments elevated in lung diseases such as COPD, SCC, or IPF, comprising a neo-epitope formed at a cleavage site by cleavage in vivo of elastin by a proteinase by contacting a sample with an antibody having specific binding affinity for a the neo-epitope amino acid sequence and determining the level of binding, where the antibody binds one of the following terminal sequences: ...FGPGVV ...VPGLGV IKAPKL... and antibodies and immunoassay kits for use in such methods.
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公开(公告)号：US20180238903A1
公开(公告)日：2018-08-23
申请号：US15753424
申请日：2016-08-16
CPC分类号： G01N33/6887 , C07K16/18 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N2333/78
摘要： The invention provides an immunological binding partner specifically reactive with a C-terminal epitope of the α1 chain of collagen Type VIII or with an N-terminal epitope of the mature form of the α1 chain of collagen Type VIII, and a method of immunoassay for detecting or quantitating in a sample the C-terminal epitope or the N-terminal epitope of the mature α1 chain of collagen type VIII.
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公开(公告)号：US10001490B2
公开(公告)日：2018-06-19
申请号：US15111062
申请日：2015-01-08
IPC分类号： G01N33/53 , G01N33/68 , C07K16/18 , C07K16/40 , G01N33/577
CPC分类号： G01N33/6878 , C07K16/18 , C07K16/40 , C07K2317/33 , C07K2317/34 , G01N33/577 , G01N33/6893 , G01N2333/78 , G01N2333/96411 , G01N2333/96419 , G01N2800/122 , G01N2800/7052
摘要： Provided is a method of bioassay for the quantification of peptide fragments elevated in lung diseases such as COPD, SCC, or IPF. The peptide fragments comprise a neo-epitope formed at a cleavage site by cleavage in vivo of elastin by a proteinase. In the method a sample is contacted with an antibody having specific binding affinity for the neo-epitope amino acid sequence and determining the level of binding is determined where the antibody binds one of the following terminal sequences: . . . FGPGVV, . . . VPGLGV or IKAPKL . . . . Also provided are antibodies and immunoassay kits for use in such methods.
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公开(公告)号：US09459260B2
公开(公告)日：2016-10-04
申请号：US14122349
申请日：2012-05-23
IPC分类号： G01N31/00 , G01N33/53 , G01N33/68 , G01N33/564 , C07K16/18
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/564 , G01N33/6842 , G01N2333/78 , G01N2800/102
摘要： An assay for citrullinated fragments of SOCS-2, Alpha 1 anti tyrpsin, versican, biglycan, laminin, or other protein having a terminal antibody binding site comprising citrulline in a blood derived sample shows diagnostic relevance in relation to rheumatoid arthritis or fibrotic disease.
摘要翻译： 在血液衍生的样品中具有包含瓜氨酸的末端抗体结合位点的SOCS-2，α1抗酪氨酸蛋白酶，多核苷酸，二聚糖，层粘连蛋白或其他蛋白质的瓜氨酸化片段的测定显示与类风湿性关节炎或纤维化疾病有关的诊断意义。
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公开(公告)号：US20160223568A1
公开(公告)日：2016-08-04
申请号：US15014241
申请日：2016-02-03
申请人： Federica Genovese , Mette Juul Nielsen , Lise Larsen , Diana Julie Oersnes-Leeming , Morten Karsdal
发明人： Federica Genovese , Mette Juul Nielsen , Lise Larsen , Diana Julie Oersnes-Leeming , Morten Karsdal
IPC分类号： G01N33/68 , G01N33/577
CPC分类号： G01N33/6893 , G01N33/577 , G01N2333/78 , G01N2800/085 , G01N2800/52 , G01N2800/7052
摘要： Provided herein is a sandwich immunoassay for detecting cross-linked PIIINP that has at least two strands of PIIINP joined together by inter-strand cross-linking each having a C-terminal neo-epitope of PIIINP that is generated by N-protease cleavage of intact type III procollagen. A biological sample having the cross-linked PIIINP is contacted with a first surface-bound monoclonal antibody and then by a second monoclonal antibody, both specifically reactive with a neoepitope in the C-terminal sequence of PIIINP, and then binding of the second monoclonal antibody is determined. Also provided is a method for evaluating the efficacy of an antagonist drug targeting lysyl oxidases via the immunoassay and a kit containing a solid support binding the first monoclonal antibody and containing the second monoclonal antibody.
摘要翻译： 本文提供了一种夹心免疫测定法，用于检测交联的PIIINP，其具有通过链间交联连接在一起的至少两条PIIINP链，每条链均具有由完整的N-蛋白酶切割产生的PIIINP的C-末端新表位 III型原胶原。 将具有交联的PIIINP的生物样品与第一表面结合的单克隆抗体接触，然后与第二单克隆抗体接触，所述第二单克隆抗体与PIIINP的C末端序列中的新表皮特异性反应，然后与第二单克隆抗体 决心，决意，决定。 还提供了用于通过免疫测定法评估靶向赖氨酰氧化酶的拮抗剂药物的功效的方法，以及含有结合第一单克隆抗体并含有第二单克隆抗体的固体支持物的试剂盒。
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公开(公告)号：US20130079295A1
公开(公告)日：2013-03-28
申请号：US13695021
申请日：2011-04-27
申请人： Morten A. Karsdal , Per Qvist , Qinlong Zheng
发明人： Morten A. Karsdal , Per Qvist , Qinlong Zheng
IPC分类号： A61K36/488
CPC分类号： A61K36/488
摘要： Excessive articular cartilage degradation is treated or prevented by administration to a mammal such as a human Pueraria lobata (Kudzu) root or an extract thereof.
摘要翻译： 通过给予哺乳动物例如人葛根（葛根）根或其提取物治疗或预防过度的关节软骨退化。
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