公开(公告)号：US08995618B2

公开(公告)日：2015-03-31

申请号：US14109861

申请日：2013-12-17

申请人： Oraya Therapeutics, Inc.

发明人： Michael Gertner

IPC分类号： A61N5/10 ,  G21K5/08 ,  A61B6/00

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A portable orthovoltage radiotherapy system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system.

公开(公告)号：US08457277B2

公开(公告)日：2013-06-04

申请号：US12755378

申请日：2010-04-06

申请人： Michael Gertner ,  Steven D. Hansen

发明人： Michael Gertner ,  Steven D. Hansen

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is configured to deliver a therapeutic dose of radiation to a target structure in a patient. The target tissues are placed in a global coordinate system based on ocular imaging. The target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. A treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. A fiducial marker is used to identify the location of the target tissues. The device automatically turns off with excessive movement outside of alignment along an axis of the eye. Radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 放射外科系统被配置为将治疗剂量的辐射递送到患者中的目标结构。 将目标组织置于基于眼睛成像的全局坐标系中。 全局坐标系内的目标组织导致基于坐标系内的目标组织定向的自动定位系统的方向。 使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 使用基准标记来识别靶组织的位置。 该装置沿着眼睛的轴线的对准外部的过度运动自动关闭。 描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其他治疗之前，之前或之后进行递送。

公开(公告)号：US20120177179A1

公开(公告)日：2012-07-12

申请号：US13345655

申请日：2012-01-06

申请人： Michael Gertner

发明人： Michael Gertner

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： Methods described herein include selecting a target disease having an associated therapeutic dose of radiation, determining a maximal energy in an x-ray radiation beam to be emitted from a radiotherapy system to deliver a therapeutic dose of radiation associated with the target disease to target tissue in a patient, the selected disease of the plurality of diseases requiring differing maximal energies of the x-ray radiation beam to achieve the associated therapeutic dose of radiation than the maximal energy required to achieve the associated therapeutic dose of radiation for another disease, and outputting to an output module an indication of the determined maximal energy. Methods carried out in a system that can include a processing module that receives an input including a selection of a target disease, and an output module, coupled to the processing module, that outputs, an indication of the determined maximal energy.

摘要翻译： 本文描述的方法包括选择具有相关联的治疗剂量的辐射的靶疾病，确定要从放射治疗系统发射的x射线辐射束中的最大能量，以将与靶疾病相关的治疗剂量的放射线递送至靶组织 患者，所选择的多种疾病需要X射线辐射束的最大能量的不同以达到与实现相关治疗剂量的另一种疾病的辐射所需的最大能量相关联的治疗剂量的辐射，并输出至 输出模块指示确定的最大能量。 在可以包括接收包括目标疾病选择的输入的处理模块的系统中执行的方法以及耦合到处理模块的输出模块，其输出所确定的最大能量的指示。

公开(公告)号：US20110170665A1

公开(公告)日：2011-07-14

申请号：US13069318

申请日：2011-03-22

申请人： Michael Gertner

发明人： Michael Gertner

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，眼睛结构被放置在基于眼睛成像的全局坐标系中，其导致自动定位系统的方向。 在一些实施例中，追踪眼结构的位置并与放射外科系统有关。 在一些实施方案中，治疗计划用于待治疗的特定疾病和/或要避免的结构。 在一些实施例中，基准有助于定位系统。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US07978818B2

公开(公告)日：2011-07-12

申请号：US12493136

申请日：2009-06-26

申请人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

发明人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Mark Arnoldussen ,  Matt Herron

IPC分类号： A61N5/10 ,  G21K5/08 ,  A61B6/08

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilised in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。 在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。 在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施方案中，使用基准标记来鉴定靶组织的位置。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US07912179B2

公开(公告)日：2011-03-22

申请号：US12142718

申请日：2008-06-19

申请人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Matt Herron

发明人： Michael Gertner ,  Steven D. Hansen ,  Erik Chell ,  Matt Herron

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。 在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。 在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施方案中，使用基准标记来鉴定靶组织的位置。 在一些实施例中，眼睛被保持并且与系统对准。 在一些实施例中，设备沿着眼睛的轴线的对准内部的过度运动自动关闭。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US20100260320A1

公开(公告)日：2010-10-14

申请号：US12759398

申请日：2010-04-13

申请人： Michael Gertner

发明人： Michael Gertner

IPC分类号： A61N5/10 ,  G01N23/00

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system. In some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，将眼部结构置于基于眼睛成像的全局坐标系中。 在一些实施例中，全局坐标系内的目镜结构导致基于坐标系内的眼睛结构而被引导的自动定位系统的方向。 在一些实施例中，跟踪眼结构的位置并且与放射外科手术系统的状态相关。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施例中，结构是眼睛，并且眼睛被系统跟踪。 在一些实施例中，眼睛被保持就位，并且在一些实施例中，眼睛被患者固定。 在一些实施例中，将基准置于眼睛上以帮助定位。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US20100172473A1

公开(公告)日：2010-07-08

申请号：US12725406

申请日：2010-03-16

申请人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

发明人： Michael Gertner ,  Erik Chell ,  Steven D. Hansen ,  Mark Arnoldussen ,  Matt Herron ,  Kuang-Hung Pan

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system. In some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

摘要翻译： 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，将眼部结构置于基于眼睛成像的全局坐标系中。 在一些实施例中，全局坐标系内的目镜结构导致基于坐标系内的眼睛结构而被引导的自动定位系统的方向。 在一些实施例中，跟踪眼结构的位置并且与放射外科手术系统的状态相关。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施例中，结构是眼睛，并且眼睛被系统跟踪。 在一些实施例中，眼睛被保持就位，并且在一些实施例中，眼睛被患者固定。 在一些实施例中，将基准置于眼睛上以帮助定位。 在一些实施例中，使用眼睛的反射来帮助定位。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

公开(公告)号：US07564946B2

公开(公告)日：2009-07-21

申请号：US12023905

申请日：2008-01-31

申请人： Michael Gertner

发明人： Michael Gertner

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/506 ,  A61B2017/306 ,  A61F9/009 ,  A61N5/1017 ,  A61N5/103 ,  A61N2005/105 ,  A61N2005/1056 ,  A61N2005/1091

摘要： A radiosurgery system configured to deliver a therapeutic dose of radiation to a target structure in a patient is described. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system, and these ocular structures are used to direct an automated positioning system. In some embodiments, the position of ocular structures is tracked and related to the status of the radiosurgery system, and a treatment plan is utilized in which beam energy, direction, and duration of treatment is determined and/or structures to be avoided. In some embodiments, an eye is tracked by the system. The eye can be held in place, and the eye can be fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning, or a reflection off the eye is used to aid in positioning.

摘要翻译： 描述了被配置为将治疗剂量的辐射递送到患者中的目标结构的放射外科系统。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施例中，眼结构被放置在全局坐标系中，并且这些眼结构用于引导自动定位系统。 在一些实施例中，跟踪眼结构的位置并且与放射外科手术系统的状态相关，并且使用治疗计划，其中确定治疗的束能量，方向和持续时间和/或要避免的结构。 在一些实施例中，眼睛被系统跟踪。 眼睛可以保持在适当位置，眼睛可以由患者固定。 在一些实施例中，基准被放置在眼睛上以帮助定位，或者使用眼睛的反射来辅助定位。

公开(公告)号：US20090182310A1

公开(公告)日：2009-07-16

申请号：US12027069

申请日：2008-02-06

申请人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron

发明人： Michael Gertner ,  Mark Arnoldussen ,  Matt Herron

IPC分类号： A61F9/00 ,  A61N5/10

CPC分类号： A61N5/1017 ,  A61B17/0231 ,  A61F9/008 ,  A61F9/00804 ,  A61F9/00819 ,  A61F9/00821 ,  A61F9/009 ,  A61F2009/00863 ,  A61F2009/00865 ,  A61F2009/00872 ,  A61F2009/00895

摘要： A method and system for performing an ocular irradiation procedure on a patient's eye is disclosed. The system includes a head support for supporting the patient's head, an eye-contact device attachable to the front portion of the patient's eye, to stabilize the position of the eye; and a position detector for determining the position of the contact device in the external coordinate system. A source of a collimated electromagnetic radiation beam in the system is controlled by a beam-positioning assembly for positioning the beam source such that the beam, when activated, is aimed along a selected path at a selected coordinate in the external coordinate system corresponding to a selected target region in the patient's eye.

摘要翻译： 公开了一种对患者眼睛进行眼部照射手术的方法和系统。 该系统包括用于支撑患者头部的头部支撑件，可附接到患者眼睛前部的眼睛接触装置，以稳定眼睛的位置; 以及位置检测器，用于确定接触装置在外部坐标系中的位置。 系统中的准直电磁辐射束的源由用于定位光束源的光束定位组件控制，使得当被激活时该光束沿着选定的路径被瞄准在对应于外部坐标系的外部坐标系中的选定坐标 在患者眼睛中选择的目标区域。