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公开(公告)号：US20240382957A1
公开(公告)日：2024-11-21
申请号：US18386375
申请日：2023-11-02
Applicant: PLEXBIO CO., LTD.
Inventor： Dean TSAO , Fengkan LU , Chien Teng KAO
Abstract: An automatic sample preparation system is disclosed. The automatic sample preparation system integrates sample pretreatment, extraction, quantitation, and solution preparation into one system. A replacement of manual operations with an automatic system can reduce time and labor costs, reduce human errors, and reduce contamination risk.
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公开(公告)号：US12099011B2
公开(公告)日：2024-09-24
申请号：US17083182
申请日：2020-10-28
Applicant: PLEXBIO CO., LTD.
Inventor： Cheng-Tse Lin , Yi-Ming Sun , Kuei-Shen Hsu , Liang-Han Chang , Yao-Kuang Chung , Chin-Yun Wu , Chin-Shiou Huang
IPC: G01N21/64 , B01L3/00 , C08F20/18 , C08F120/14 , C08K5/357 , C09B69/10 , C09K11/02 , C09K11/06 , G01N21/27 , G01N21/93
CPC classification number: G01N21/6452 , B01L3/5085 , C08F20/18 , C08F120/14 , C08K5/357 , C09B69/101 , C09B69/103 , C09B69/105 , C09B69/109 , C09K11/02 , C09K11/06 , G01N21/278 , G01N21/6486 , B01L2200/12 , B01L2200/148 , B01L2300/0829 , C09K2211/1033 , G01N2201/127
Abstract: The present invention relates to a fluorescent polymer cast on the surface of wells of a plate and a plate comprising the fluorescent polymer. The plate is used in a method for calibrating read-out values of plate readers. The method for calibrating the plate readers can effectively reduce the deviation of read-out values among different plate readers.
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公开(公告)号：US10302640B2
公开(公告)日：2019-05-28
申请号：US15374930
申请日：2016-12-09
Applicant: PLEXBIO CO., LTD.
Inventor： Dean Tsao , Chin-Shiou Huang , Yao-Kuang Chung
IPC: G01N33/553 , G01N33/545 , G01N33/543 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834
Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.
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公开(公告)号：US20180195113A1
公开(公告)日：2018-07-12
申请号：US15836809
申请日：2017-12-08
Applicant: PLEXBIO CO., LTD.
Inventor： Dean Tsao , Chin-Shiou Huang , Shian pin Hu
IPC: C12Q1/6827 , C12Q1/6886 , C12Q1/6816 , C12Q1/6834
Abstract: Provided herein are methods and kits for detecting the presence of DNA mutations in the KRAS, BRAF, CTNNB1, and APC genes. The methods and kits employ microcarriers, each with a probe specific for a DNA mutation in the KRAS, BRAF, CTNNB1, or APC gene and an identifier unique to the probe sequence. Upon isolation and amplification of DNA from a sample, hybridization of amplified DNA with a probe, specific for a DNA mutation, that is coupled to a microcarrier indicates the presence of the DNA mutation in the sample. Since each microcarrier can be identified through detection of the identifier, multiplex screening assays for multiple mutations in each of the KRAS, BRAF, CTNNB1, and APC genes are provided.
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公开(公告)号：US20250027963A1
公开(公告)日：2025-01-23
申请号：US18778582
申请日：2024-07-19
Applicant: PLEXBIO CO., LTD.
Inventor： Dean TSAO , Fengkan LU , Cheng-Tse LIN
IPC: G01N35/00
Abstract: The present disclosure relates generally to devices and systems for performing automated multiplex assays, and methods of using such devices and systems. In some embodiments, the devices and systems comprise a magnetic module that simplifies and automates processing of encoded microcarriers for molecular and immunoassays.
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公开(公告)号：US20240125776A1
公开(公告)日：2024-04-18
申请号：US18516803
申请日：2023-11-21
Applicant: Plexbio Co., Ltd.
Inventor： Dean TSAO , Chin-Shiou HUANG , Cheng-Tse LIN , Chien-Te WU , FengKan LU
IPC: G01N33/543 , G01N21/64 , G01N33/531
CPC classification number: G01N33/54326 , G01N21/6458 , G01N33/531 , G01N33/54346 , G01N2446/10
Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and comprise a capture agent for analyte detection and a substantially transparent magnetic polymer. The analog code is generated by a two-dimensional shape of a substantially non-transparent layer. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.
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公开(公告)号：US20230052147A1
公开(公告)日：2023-02-16
申请号：US17758511
申请日：2021-01-07
Applicant: PLEXBIO CO., LTD.
Inventor： Dean TSAO , Chin-Shiou HUANG , Shian Pin HU , Fei-Yu CHANG , Yi Ling HSIEH
IPC: C12Q1/6827 , C12Q1/6886 , C12Q1/6834
Abstract: Provided herein are methods and kits for detecting the presence of DNA and/or RNA mutations associated with cancer (e.g., lung cancer). The methods and kits employ microcarriers, each with a probe specific for a DNA or RNA mutation and an identifier unique to the probe sequence. Upon isolation and amplification of nucleic acids from a sample, hybridization of amplified DNA with a probe, specific for a DNA or RNA mutation, that is coupled to a microcarrier indicates the presence of the mutation in the sample. Since each microcarrier can be identified through detection of the identifier, multiplex screening assays are provided. Representative genes that can be screened for mutations include, e.g., KRAS, NRAS, PIK3CA, BRAF, EGFR, AKT1, MEK1, and HER2 for DNA mutations and/or ALK, ROS, RET, NTRK1, and cMET for RNA mutations.
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公开(公告)号：US11579522B2
公开(公告)日：2023-02-14
申请号：US16386092
申请日：2019-04-16
Applicant: Plexbio Co., Ltd.
Inventor： Dean Tsao , Chin-Shiou Huang , Yao-Kuang Chung
IPC: G03F1/80 , G01N33/543 , C12Q1/6813 , G02F1/1362 , G09G3/36 , H01L27/12 , B01L3/00 , G03F7/004 , G03F7/00 , C12Q1/6816 , C12Q1/6834 , G01N33/545 , G01N33/553
Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.
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9.发明申请MAGNETIC AGGREGATING AND WASHING DEVICE FOR IN VITRO ASSAYS AND METHODS OF USE THEREOF 有权用于体外测定的磁性聚集和洗涤装置及其使用方法
公开(公告)号：US20140242614A1
公开(公告)日：2014-08-28
申请号：US13779465
申请日：2013-02-27
Applicant: PLEXBIO CO., LTD.
Inventor： Chien-Teng KAO , Yao-Kuang CHUNG , Pei-San LEE
IPC: G01N1/34
CPC classification number: G01N1/34 , B01L9/523 , B01L2200/0668 , B01L2300/0829 , B01L2400/0409 , B01L2400/043 , G01N35/0098 , G01N2035/00495
Abstract: Provided herein are magnetic aggregating and washing devices. Further provided herein are methods using magnetic aggregation to aggregate and wash sample molecules in an in vitro assay.
Abstract translation: 本文提供了磁聚集和洗涤装置。 本文进一步提供的是在体外测定中使用磁性聚集来聚集和洗涤样品分子的方法。
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公开(公告)号：US20210041362A1
公开(公告)日：2021-02-11
申请号：US17083182
申请日：2020-10-28
Applicant: PLEXBIO CO., LTD.
Inventor： Cheng-Tse LIN , Yi-Ming SUN , Kuei-Shen HSU , Liang-Han CHANG , Yao-Kuang CHUNG , Chin-Yun WU , Chin-Shiou HUANG
IPC: G01N21/64 , B01L3/00 , C09K11/06 , C09K11/02 , C08K5/357 , C08F20/18 , C09B69/10 , G01N21/27 , C08F120/14
Abstract: The present invention relates to a fluorescent polymer cast on the surface of wells of a plate and a plate comprising the fluorescent polymer. The plate is used in a method for calibrating read-out values of plate readers. The method for calibrating the plate readers can effectively reduce the deviation of read-out values among different plate readers.
