公开(公告)号：US11083556B2

公开(公告)日：2021-08-10

申请号：US16436711

申请日：2019-06-10

申请人： Pulmonx Corporation

发明人： Ryan Olivera ,  Hoang Nguyen

IPC分类号： A61F2/95 ,  A61F2/00 ,  A61B17/12 ,  A61F2/04 ,  B65B1/04 ,  A61B17/00

摘要： Devices, methods, and systems are provided for loading an implantable device into a container. One aspect of the loading system contains a loader element with a loading tunnel that is configured to gradually contract an implantable device into a compressed state of reduced size relative to an expanded state as the implantable device travels through the loading tunnel.

公开(公告)号：US10758333B2

公开(公告)日：2020-09-01

申请号：US15714868

申请日：2017-09-25

申请人： Pulmonx Corporation

发明人： Sri Radhakrishnan ,  Ryan Olivera

IPC分类号： A61F2/04 ,  A61B17/12 ,  A61M16/04 ,  A61M16/20

摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region. An exemplary flow control device is configured to block fluid flow in the inspiratory direction and the expiratory direction at normal breathing pressures and allow fluid flow in the expiratory direction at coughing pressures.

公开(公告)号：US10478125B2

公开(公告)日：2019-11-19

申请号：US14195532

申请日：2014-03-03

申请人： Pulmonx Corporation

发明人： Lutz Freitag

IPC分类号： A61B5/00 ,  A61B5/08

摘要： Devices systems and methods are disclosed for removing secretions from the lumen of a functional assessment catheter for the lungs. The system comprises a flushing unit configured to deliver a clearing fluid to the lumen of the pulmonary catheter to remove debris, secretions, or moisture from the lumen or sensors.

公开(公告)号：US10413300B2

公开(公告)日：2019-09-17

申请号：US15182453

申请日：2016-06-14

申请人： PulmonX Corporation

发明人： Sri Radhakrishnan ,  Ryan Olivera

IPC分类号： A61B5/08 ,  A61B17/12 ,  A61B5/00 ,  A61M25/10 ,  A61M25/01 ,  A61M16/04 ,  A61M25/00 ,  A61F2/04

摘要： Devices, methods, and systems are provided for occluding a collateral flow channel between a target lung compartment and an adjacent lung compartment. A video-assisted thoracoscopic device is inserted into a thoracic cavity of a patient and positioned at a fissure between a target lung compartment and an adjacent lung compartment. A collateral flow channel between the target lung compartment and the adjacent lung compartment is then identified using the video-assisted thoracoscopic device and an agent is injected into the collateral flow channel, thereby reducing the collateral flow channel.

公开(公告)号：US10314992B2

公开(公告)日：2019-06-11

申请号：US14703670

申请日：2015-05-04

申请人： Pulmonx Corporation

发明人： Nikolai Aljuri ,  Rodney C. Perkins ,  Ryan Olivera ,  Hoang Nguyen ,  Srikanth Radhakrishnan ,  Niyazi Beyhan

IPC分类号： A61M16/04 ,  A61B17/12 ,  A61M16/00 ,  A61B1/267 ,  A61B5/00 ,  A61B5/08 ,  A61M16/20 ,  A61M25/10 ,  A61F2/04

摘要： The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope.

公开(公告)号：US09999701B2

公开(公告)日：2018-06-19

申请号：US15425216

申请日：2017-02-06

申请人： Pulmonx

发明人： Edward P. Ingenito ,  James A. Krom ,  Alexander Schwarz ,  Larry W. Tsai

IPC分类号： A61L24/06 ,  C08J9/30 ,  C08J9/36 ,  C08J3/075 ,  A61L24/00 ,  C08F116/06 ,  A61M25/10

CPC分类号： A61L24/06 ,  A61L24/0031 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/043 ,  A61L2300/604 ,  A61L2400/06 ,  A61M25/10 ,  A61M2025/1052 ,  A61M2210/1039 ,  C08F116/06 ,  C08F2810/20 ,  C08J3/075 ,  C08J9/30 ,  C08J9/36 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2329/04

摘要： One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.

公开(公告)号：US09364168B2

公开(公告)日：2016-06-14

申请号：US13174665

申请日：2011-06-30

申请人： Surag Mantri

发明人： Surag Mantri

IPC分类号： A61B5/08 ,  A61B5/087 ,  A61B5/00

CPC分类号： A61B5/087 ,  A61B5/091 ,  A61B5/6853

摘要： A method of diagnosing an air leak in a lung compartment of a patient may include: advancing a diagnostic catheter into an airway leading to the lung compartment; inflating an occluding member on the catheter to form a seal with a wall of the airway and thus isolate the lung compartment; measuring air pressure within the lung compartment during multiple breaths, using the diagnostic catheter; displaying the measured air pressure as an air pressure value on a console coupled with the diagnostic catheter; and determining whether an air leak is present in the lung compartment based on the displayed air pressure value during the multiple breaths.

摘要翻译： 诊断患者肺隔室中的空气泄漏的方法可以包括：将诊断导管推进通向肺室的气道; 使导管上的闭塞构件膨胀以与气道的壁形成密封，从而隔离肺隔室; 使用诊断导管在多次呼吸期间测量肺隔室内的空气压力; 将测量的空气压力作为与诊断导管连接的控制台上的空气压力值显示; 以及基于所述多次呼吸期间显示的气压值来确定所述肺室中是否存在空气泄漏。

公开(公告)号：US08808194B2

公开(公告)日：2014-08-19

申请号：US13174633

申请日：2011-06-30

申请人： Surag Mantri ,  Srikanth Radhakrishnan

发明人： Surag Mantri ,  Srikanth Radhakrishnan

IPC分类号： A61B5/08

CPC分类号： A61B5/14552 ,  A61B1/00082 ,  A61B1/2676 ,  A61B5/08 ,  A61B5/085 ,  A61B5/087 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/6853 ,  A61M16/0003 ,  A61M16/0404 ,  A61M2016/0036 ,  A61M2016/102 ,  A61M2230/205 ,  A61M2230/43

摘要： Methods and systems for targeting, accessing and diagnosing diseased lung compartments are disclosed. The method comprises introducing a diagnostic catheter with an occluding member at its distal end into a lung segment via an assisted ventilation device; inflating the occluding member to isolate the lung segment; and performing a diagnostic procedure with the catheter while the patient is ventilated. The proximal end of the diagnostic catheter is configured to be attached to a console. The method may also comprise introducing the diagnostic catheter into the lung segment; inflating the occluding member to isolate the lung segment; and monitoring blood oxygen saturation. The method may further comprise introducing the diagnostic catheter into the lung segment; determining tidal flow volume in the lung segment; determining total lung capacity of the patient; and determining a flow rank value based on the tidal flow volume of the lung segment and the total lung capacity.

摘要翻译： 公开了用于靶向，访问和诊断患病肺隔室的方法和系统。 该方法包括通过辅助通气装置将具有阻塞构件的诊断导管在其远端引入肺段; 使闭塞部件膨胀以分离肺段; 并且在患者通气时用导管执行诊断程序。 诊断导管的近端被配置为附接到控制台。 该方法还可以包括将诊断导管引入肺段中; 使闭塞部件膨胀以分离肺段; 并监测血氧饱和度。 该方法还可以包括将诊断导管引入肺部段中; 确定肺段的潮汐流量; 确定患者的总肺容量; 并且基于肺段的潮汐流量和总肺容量来确定流量值。

公开(公告)号：US20140081308A1

公开(公告)日：2014-03-20

申请号：US13787223

申请日：2013-03-06

申请人： Anthony Wondka ,  Peter P. Soltesz ,  Robert Kotmel ,  Nadia Matov ,  Thomas Crowder

发明人： Anthony Wondka ,  Peter P. Soltesz ,  Robert Kotmel ,  Nadia Matov ,  Thomas Crowder

IPC分类号： A61B17/12

CPC分类号： A61B17/12104 ,  A61B1/012 ,  A61B1/2676 ,  A61B17/12022 ,  A61B17/12172 ,  A61B2017/00867 ,  A61B2017/12054 ,  A61B2017/12086 ,  A61B2017/22069

摘要： Methods, systems and devices are provided for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The methods are minimally invasive with instruments being introduced through the mouth (endotracheally) and rely on isolating the target lung tissue segment from other regions of the lung and occluding various lung passageways with the use of occlusal stents. The occlusal stents are delivered with the use of an occlusal stent delivery system which is loaded with the occlusal stent with the use of an occlusal stent loading system.

摘要翻译： 提供了方法，系统和装置，用于在患有慢性阻塞性肺病或其它需要肺部分离或减少肺容积的其他病症的患者中进行肺容积减少。 这些方法是微创的，仪器通过口腔（气管内）引入，并依赖于使用咬合支架将目标肺组织区段与肺其他区域隔离并阻塞各种肺通道。 使用咬合支架输送系统递送咬合支架，该系统使用咬合支架装载系统装载咬合支架。

公开(公告)号：US20140058433A1

公开(公告)日：2014-02-27

申请号：US13767793

申请日：2013-02-14

申请人： Michael Barrett ,  Antony J. Fields ,  Michael J. Hendricksen ,  Ronald R. Hundertmark ,  John G. McCutcheon ,  Alan R. Rapacki ,  Michael Regan ,  Steve Wallace

发明人： Michael Barrett ,  Antony J. Fields ,  Michael J. Hendricksen ,  Ronald R. Hundertmark ,  John G. McCutcheon ,  Alan R. Rapacki ,  Michael Regan ,  Steve Wallace

IPC分类号： A61B17/12 ,  A61F2/04

CPC分类号： A61B17/12168 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12104 ,  A61B17/12172 ,  A61B2017/1205 ,  A61F2/04 ,  A61F2/24 ,  A61F2002/043

摘要： Methods and devices are adapted for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.

摘要翻译： 方法和装置适于调节流入和流出患者肺部区域的流体流动，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。 根据示例性程序，确定的肺部区域被靶向用于治疗。 然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。