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10 条记录 (耗时 0.011 秒)

    16-Amino-18,19,20-trinor-prostaglandin derivatives, and acid addition salts
    1.
    发明授权
    16-Amino-18,19,20-trinor-prostaglandin derivatives, and acid addition salts 失效
    16-氨基-18,19,20-三肽前列腺素衍生物和酸加成盐

    公开(公告)号：US4418205A

    公开(公告)日：1983-11-29

    申请号：US329039

    申请日：1981-12-09

    申请人： Eva Toth-Sarudy ,  Gabor Ambrus ,  Gyorgy Cseh ,  Janos Borvendeg ,  Imre Moravcsik ,  Gabriella Mezei

    发明人： Eva Toth-Sarudy ,  Gabor Ambrus ,  Gyorgy Cseh ,  Janos Borvendeg ,  Imre Moravcsik ,  Gabriella Mezei

    IPC分类号： A61K31/557 ,  A61K31/5575 ,  A61P15/00 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07C177/00

    CPC分类号： C07C405/0041 ,  Y02P20/55

    摘要： The invention relates to new 16-amino-18,19,20-trinor-prostaglandin derivatives of general formula I, having at C-17 a substituted or unsubstituted phenyl group, wherein C-15 and C-16 may have either S or R configuration, Y stands for a hydrogen atom or a lower alkyl group, W stands for a hydrogen atom, halogen atom, hydroxy group, lower alkyl or alkoxy group, and their acid addition salts. These compounds can be prepared by removing the ester group and the p-nitrobenzyloxycarbonyl protective group of a 9.alpha.,11.alpha.,15-trihydroxy-16-p-nitrobenzyloxycarbonylamido-17-phenyl-5-cis,13-trans-18,19,20-trinor-prostadienoic acid derivative of general formula XII--wherein C-15 and C-16 may have either S or R configuration, W is as defined above, and Y stands for a lower alkyl group--in an optional sequence with the limitation that in those compounds of general formula I where W is as defined above and Y stands for a lower alkyl group, solely the p-nitrobenzyloxycarbonyl group is removed, and the resulting product of general formula I is optionally converted with an organic or inorganic acid into a salt.The new prostaglandin derivatives of the invention have valuable therapeutical properties, and can be applied in cattle raising for estrus and birth synchronization, furthermore in the veterinary praxis for the treatment of sterility, chronic endometritis and pyometry.

    摘要翻译： 本发明涉及具有C-17取代或未取代的苯基的通式I的新的16-氨基-18,19,20-三核 - 前列腺素衍生物，其中C-15和C-16可具有S或R 构型中，Y表示氢原子或低级烷基，W表示氢原子，卤素原子，羟基，低级烷基或烷氧基，以及它们的酸加成盐。 这些化合物可以通过除去9α，11α，15-三羟基-16-对硝基苄氧羰基酰胺基-17-苯基-5-顺式，13-trn-18的酯基和对硝基苄氧羰基保护基来制备， 其中C-15和C-16可以具有S或R构型，W如上所定义，Y代表低级烷基 - 在任选的序列中，具有通式XII-的19,20-三过 - 前列腺素酸衍生物 - 在通式I的那些化合物中的限制，其中W如上所定义，Y代表低级烷基，仅除去对硝基苄氧基羰基，所得到的通式I的产物任选地用有机或无机 酸变成盐。 本发明的新型前列腺素衍生物具有有价值的治疗特性，可用于发情期和出生同步的养牛，此外还适用于无菌治疗，慢性子宫内膜炎和高血压的兽医学应用。

    D-Phenylalanyl-L-prolyl-L-arginine aldehyde sulfate and process for the preparation thereof
    5.
    发明授权
    D-Phenylalanyl-L-prolyl-L-arginine aldehyde sulfate and process for the preparation thereof 失效
    D-苯丙氨酰-L-脯氨酰-L-精氨酸醛硫酸盐及其制备方法

    公开(公告)号：US4399065A

    公开(公告)日：1983-08-16

    申请号：US337288

    申请日：1982-01-05

    申请人： Sandor Bajusz ,  Erzsebet Szell nee Hasenohrl ,  Eva Barabas ,  Daniel Bagdy

    发明人： Sandor Bajusz ,  Erzsebet Szell nee Hasenohrl ,  Eva Barabas ,  Daniel Bagdy

    IPC分类号： C07K5/08 ,  A61K38/00 ,  A61K38/06 ,  A61P7/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/087 ,  C07C103/52

    CPC分类号： C07K5/06078 ,  Y02P20/55

    摘要： The invention relates to D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate, highly stable in aqueous solution, and to a process for preparing it from D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate or N.sup.G -carboxy derivative containing an acid-sensitive protecting group at its amino terminal, wherein the acid sensitive amino terminal protecting group or optionally the N.sup.G -carboxy group is removed with 1 to 12 N sulfuric acid, applied in 1 to 12 equivalent amounts and the resulting free tripeptide aldehyde sulfate is isolated. The D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate of the invention possesses valuable anticoagulant activity.

    摘要翻译： 本发明涉及在水溶液中高度稳定的D-苯丙氨酰-L-脯氨酰基-L-精氨酸醛硫酸酯，以及由D-苯丙氨酰-L-脯氨酰基-L-精氨酸醛半硫酸酯或NG-羧基衍生物制备的方法 在其氨基末端含有酸敏感性保护基，其中用1至12N硫酸除去酸敏感氨基末端保护基团或任选的NG-羧基基团，以1至12当量施用，得到的游离三肽醛 分离出硫酸盐。 本发明的D-苯丙氨酰-L-脯氨酰-L-精氨酸醛硫酸盐具有有价值的抗凝血活性。

    Turbogenerator having dual cooling
    9.
    发明授权
    Turbogenerator having dual cooling 失效
    涡轮发电机具有双重冷却功能

    公开(公告)号：US4152610A

    公开(公告)日：1979-05-01

    申请号：US778243

    申请日：1977-03-16

    申请人： Mihaly Wallenstein

    发明人： Mihaly Wallenstein

    IPC分类号： H02K3/24 ,  H02K9/00

    CPC分类号： H02K3/24

    摘要： A high-power, high-speed synchronous rotary electric machine having an airgap defined therein, includes a cylindrical rotor havng a shaft, slots defined in the rotor for receiving a rotor winding, subslots defined in the rotor in communication with the slots, a plurality of cooling channels defined in the slots in connection with the rotor winding and adjacently disposed along cylindrical surfaces coaxial with the shaft, first connecting means operative to interconnect adjacent channels to be in communication with each other, a second connecting means operative to interconnect the subslot to the channel disposed closest to the shaft, an inlet port defined in the rotor in communication with the channel disposed farthest from the shaft, and an outlet port defined in the rotor in communication with the airgap and disposed in an axial direction with respect to each other.

    摘要翻译： 具有限定在其中的气隙的大功率高速同步旋转电机包括：轴，具有限定在转子中的转子的槽，用于接收转子绕组的槽;限定在与槽连通的转子中的槽，多个 限定在与转子绕组相关的槽中的冷却通道，并且沿着与轴同轴的圆柱形表面相邻布置，第一连接装置可操作地将相邻通道相互连接以彼此连通;第二连接装置，用于将子槽互连到 设置在最靠近轴的通道，限定在转子中的通道与设置在离轴最远的通道相连通的入口端口和限定在转子中的与气隙连通并相对于彼此沿轴向设置的出口 。