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公开(公告)号：US20190045776A1
公开(公告)日：2019-02-14
申请号：US15735120
申请日：2016-06-09
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS
发明人： Hemant THATTE , Jialan SHI
IPC分类号： A01N1/02
摘要： Provided herein, inter alia, are compositions and methods for preserving platelets in a lesion-free and functional state during extended storage periods of up to 15 days as well as methods and kits for utilizing the same. In contrast to currently available compositions and techniques for preserving platelets, platelets stored in the compositions disclosed herein are characterized by a marked decrease in “storage-lesions,” which are associated with attenuated hemostatic function. During platelet storage, the compositions disclosed herein (1) maintain and/or restore platelet energy states and morphology; (2) maintain active metabolism and buffering; (3) preserve and/or promote nitric oxide production; and (4) prevent microparticle formation, aggregation and activation during storage. As such, long term preservation in the compositions described herein produce platelets that are fully functional and lesion-free.
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公开(公告)号：US20170247456A1
公开(公告)日：2017-08-31
申请号：US15595618
申请日：2017-05-15
发明人： Gordon James Freeman , Arlene Helen Sharpe , Walter A. Blattler , Jennifer Marie Mataraza , Catherine Anne Sabatos-Peyton , Hwai Wen Chang , Gerhard Johann Frey
IPC分类号： C07K16/28
CPC分类号： C07K16/2818 , A61K39/3955 , A61K45/06 , C07K16/2896 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/566 , G01N33/57484 , G01N33/6854 , G01N2333/70596 , Y02A50/58
摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
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公开(公告)号：US20160279265A1
公开(公告)日：2016-09-29
申请号：US15032426
申请日：2014-10-29
发明人： Constance L. Cepko , Wenjun Xiong
CPC分类号： A61K48/0058 , A61K31/7115 , A61K38/1709 , A61K38/446 , A61K45/06 , A61K48/005 , A61K48/0075 , C12N2750/14143 , C12Y115/01001 , Y02A50/465
摘要： The present invention is directed to methods for the treatment or prevention of oxidative stress in a cell, e.g., photoreceptor cell, and methods for the treatment and prevention of disorders associated therewith by the administration of an agent, e.g., a nucleic acid molecule, which increases the expression and/or activity of an antioxidant defense protein.
摘要翻译： 本发明涉及用于治疗或预防细胞中的氧化应激的方法，例如感光细胞，以及通过给药例如核酸分子来治疗和预防与其相关的病症的方法，其中 增加抗氧化防御蛋白的表达和/或活性。
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公开(公告)号：US20200292544A1
公开(公告)日：2020-09-17
申请号：US16083935
申请日：2017-03-09
发明人： George M. Church , Daniel J. Mandell , Justin Feng
IPC分类号： G01N33/566 , C07K14/435
摘要： The disclosure provides a biosensor having a ligand binding domain (LBD) or its variant, wherein the stability of the LBD or its variant is conditioned on the presence of specific small molecule ligands, and wherein the LBD or its variant is fused to a reporter protein. The disclosure also provides a method of screening for small molecules that modulate protein stability.
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5.发明申请公开(公告)号：US20200278414A1
公开(公告)日：2020-09-03
申请号：US16304369
申请日：2017-05-24
发明人： Ronald L. WALSWORTH , David GLENN , Dominik BUCHER
摘要： A synchronized readout (SR) technique for spectrally selective detection of oscillating magnetic fields with sub-millihertz resolution, using coherent manipulation of solid state spins.
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公开(公告)号：US20190040416A1
公开(公告)日：2019-02-07
申请号：US16061363
申请日：2016-12-14
摘要： CRISPR/Cas Systems are provided where a tuned guide RNA is used to discriminate between two protospacer sequences of same length that differ by one nucleotide.
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公开(公告)号：US20180297214A1
公开(公告)日：2018-10-18
申请号：US15540895
申请日：2016-01-12
发明人： Joshua Aaron LESSING , George M. WHITESIDES , Yanina SHEVCHENKO , Bobak MOSADEGH , Kevin C. GALLOWAY , Alok Suryavamsee TAYI
摘要： A soft robotic device with a variety of sensors and/or imaging areas is described. The sensor and/or imaging area may be embedded in the soft body or the strain limiting layer of the soft robotic device, attached to the soft body or the strain limiting layer of the soft robotic device, or other-wise linked to the soft body or the strain limiting layer of the soft robotic device.
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公开(公告)号：US20160244817A1
公开(公告)日：2016-08-25
申请号：US15026031
申请日：2014-09-30
CPC分类号： C12Q1/6827 , C12Q1/703 , C12Q2600/106 , C12Q2600/156 , C12Q2525/15 , C12Q2525/161 , C12Q2525/179 , C12Q2525/191
摘要： Methods and compositions for determining the presence of a polymorphism at a target nucleotide position in a plurality of target nucleic acid sequences is provided.
摘要翻译： 提供了确定多个靶核酸序列中靶核苷酸位置多态性存在的方法和组合物。
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9.发明申请公开(公告)号：US20170159136A1
公开(公告)日：2017-06-08
申请号：US15325577
申请日：2015-07-10
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , C07H21/02 , C07H21/04 , C12Q2531/125 , C12Q1/6844 , C12Q2522/101 , C12Q2543/101
摘要： Methods of labelling one or more subcellular components (e.g., an organelle and/or subcellular region) in vivo are provided. Methods of labelling a protein in vivo are provided. Methods of determining a nucleic acid sequence in situ are also provided.
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公开(公告)号：US20160348120A1
公开(公告)日：2016-12-01
申请号：US15034682
申请日：2014-11-05
发明人： Kevin M. Esvelt , Stephanie Yaung
CPC分类号： C12N15/70 , A61K35/74 , C12N1/20 , C12N1/38 , C12N15/1131 , C12N15/902 , C12N2310/10 , C12N2310/20 , C12N2800/80
摘要： Stably immunized cells and methods of making stably immunized cells are provided. Methods of altering the microbiota of an ecological environment are provided. Methods of modifying target chromosomes are provided. Methods of delivering genetic material to target cells are provided.
摘要翻译： 提供稳定免疫的细胞和制备稳定免疫细胞的方法。 提供了改变生态环境的微生物群的方法。 提供了修饰靶染色体的方法。 提供将遗传物质递送至靶细胞的方法。
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