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公开(公告)号：US20230134700A1
公开(公告)日：2023-05-04
申请号：US17892553
申请日：2022-08-22
IPC分类号： A61K9/28 , A61K9/20 , A61K9/16 , A61J3/06 , A61K9/00 , A61K31/485 , A61K47/34 , A61K9/24 , A61K45/06 , A61K47/10 , A61J3/10 , B29C43/00 , A61J3/00 , B29C37/00 , B29C43/52 , B29B7/88 , B29C35/04 , B29B7/02 , B29C35/16 , B29C43/02 , B29C71/00
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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公开(公告)号：US11576899B2
公开(公告)日：2023-02-14
申请号：US16621885
申请日：2018-06-13
申请人： Purdue Pharma L.P.
发明人： Thomas Jorg Mehrling
IPC分类号： A61K31/4184 , A61P35/00 , A61N5/10
摘要： There is provided tinostamustine or a pharmaceutically acceptable salt thereof for use in the treatment of sarcomain a patient in need thereof.
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公开(公告)号：US11494387B1
公开(公告)日：2022-11-08
申请号：US16444364
申请日：2019-06-18
申请人： Purdue Pharma L.P.
发明人： Paul Blake , Kevin Brogle , Kevin Brown , Don Kyle
IPC分类号： G01N31/00 , G06F16/2457 , G06F16/93 , G06Q50/18 , G06F16/248
摘要： A system and method for extrapolating a set of specific representational identifiers that are represented or covered by a generic representational identifier found in a target document. Queries are constructed and performed on a corpus of source documents in which members of the extrapolated set of specific representational identifiers are compared to a database of representational data. By matching representational data in this way, any overlap between the generic representational data and specific instances of the generic representational identifier within the source documents is determined. In a more specific implementation, the system and method reduces the scope of the generic representational identifier such that the reduced scope generic representational identifier encompasses only novel specific representational identifiers.
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4.发明授权公开(公告)号：US11384091B2
公开(公告)日：2022-07-12
申请号：US16900600
申请日：2020-06-12
发明人： Robert Chapman , Lonn S. Rider , Qi Hong , Donald Kyle , Robert Kupper
IPC分类号： A61K31/485 , C07D489/08 , C07D489/02 , A61K9/20 , A61K9/48 , A61K9/14 , C07D489/04
摘要： In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
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公开(公告)号：US11304908B2
公开(公告)日：2022-04-19
申请号：US17027222
申请日：2020-09-21
IPC分类号： A61K9/28 , A61K9/20 , A61K9/16 , A61J3/06 , A61K9/00 , A61K31/485 , A61K47/34 , A61K9/24 , A61K45/06 , A61K47/10 , A61J3/10 , B29C43/00 , A61J3/00 , B29C37/00 , B29C43/52 , B29B7/88 , B29C35/04 , B29B7/02 , B29C35/16 , B29C43/02 , B29C71/00 , B29K71/00 , B29K105/00 , B29L31/00
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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6.发明授权公开(公告)号：US11236098B2
公开(公告)日：2022-02-01
申请号：US17202320
申请日：2021-03-15
发明人： Robert Chapman , Lonn S. Rider , Qi Hong , Robert Kupper , Donald J. Kyle
IPC分类号： A61K31/485 , C07D489/08 , C07D489/02 , A61K9/20 , A61K9/48 , A61K9/14 , C07D489/04
摘要： In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
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7.发明申请公开(公告)号：US20210198268A1
公开(公告)日：2021-07-01
申请号：US17202320
申请日：2021-03-15
发明人： Robert CHAPMAN , Lonn S. RIDER , Qi HONG , Robert KUPPER , Donald J. KYLE
IPC分类号： C07D489/08 , A61K9/20 , A61K9/14 , A61K9/48 , A61K31/485 , C07D489/04 , C07D489/02
摘要： In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
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公开(公告)号：US20210169810A1
公开(公告)日：2021-06-10
申请号：US16931803
申请日：2020-07-17
IPC分类号： A61K9/28 , A61K9/20 , A61K9/16 , A61J3/06 , A61K9/00 , A61K31/485 , A61K47/34 , A61K9/24 , A61K45/06 , A61K47/10 , A61J3/10 , B29C43/00 , A61J3/00 , B29C37/00 , B29C43/52 , B29B7/88 , B29C35/04 , B29B7/02 , B29C35/16 , B29C43/02 , B29C71/00
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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公开(公告)号：US20210000749A1
公开(公告)日：2021-01-07
申请号：US17027307
申请日：2020-09-21
IPC分类号： A61K9/28 , A61K9/20 , A61K9/16 , A61J3/06 , A61K9/00 , A61K31/485 , A61K47/34 , A61K9/24 , A61K45/06 , A61K47/10 , A61J3/10 , B29C43/00 , A61J3/00 , B29C37/00 , B29C43/52 , B29B7/88 , B29C35/04 , B29B7/02 , B29C35/16 , B29C43/02 , B29C71/00
摘要： The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
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公开(公告)号：US10774050B2
公开(公告)日：2020-09-15
申请号：US15996053
申请日：2018-06-01
申请人： Purdue Pharma L.P.
发明人： Chiyou Ni , Laykea Tafesse , Jiangchao Yao , Mark A. Youngman , Minnie Park , Bin Shao
IPC分类号： C07D239/34 , C07D239/42 , C07D403/12 , C07D401/14 , C07D405/14 , C07D233/90 , C07D401/12 , C07D403/04 , C07D405/12 , C07D401/04 , C07D413/04 , C07D239/48 , A61K31/506
摘要： The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
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