公开(公告)号：US4341112A

公开(公告)日：1982-07-27

申请号：US162093

申请日：1980-06-23

申请人： Neilson A. M. Mackay ,  John C. Beal

发明人： Neilson A. M. Mackay ,  John C. Beal

IPC分类号： G01N22/04 ,  G01N27/02

CPC分类号： G01N22/04

摘要： A method and apparatus for measuring the moisture content of bulk material which involves placing a length of leaky co-axial cable in the bulk material so as to be buried therein and spaced from an electro-magnetic sensor in the region of interest. A signal of high frequency electro-magnetic energy is injected into the cable, and at least one of phase and time of arrival of the signal at the sensor with respect to the injected signal is measured and therefrom the moisture content of the material determined. The electro-magnetic sensor is preferably a second leaky co-axial cable buried in the bulk material and spaced a selected distance from the first coaxial cable and parallel thereto. The spacing therebetween the coaxial cables is in the range of one to fifty feet and the frequency of the electro-magnetic energy is in the range of 20-500 MHz.

摘要翻译： 一种用于测量散装材料的水分含量的方法和装置，其包括将一长度的泄漏的同轴电缆放置在散装材料中，以便被埋在其中并与感兴趣区域中的电磁传感器间隔开。 将高频电磁能的信号注入到电缆中，并且测量信号相对于注入的信号在传感器处的相位和时间到达中的至少一个，从而确定材料的含水量。 电磁传感器优选地是埋在散装材料中并与第一同轴电缆间隔开一定距离并与之平行的第二泄漏同轴电缆。 同轴电缆之间的间隔在一至五十英尺的范围内，电磁能的频率在20-500MHz的范围内。

公开(公告)号：US20240341598A1

公开(公告)日：2024-10-17

申请号：US18633882

申请日：2024-04-12

申请人： Queen's University at Kingston

发明人： Yong Jun Lai

IPC分类号： A61B3/16

CPC分类号： A61B3/16

摘要： Apparatus and method for measuring and monitoring intraocular pressure (IOP) of a subject includes a contact lens disposed on the subject's eye, the contact lens having a polymer matrix and a nanowire network embedded in the polymer matrix. An electrically conductive coil is disposed in close proximity to the contact lens such that it electromagnetically couples with the nanowire network of the contact lens. A resonant frequency of the electrically conductive coil is measured and correlated with the IOP of the subject. Changes in IOP result in deformation of the nanowire network of the contact lens and a resulting change in the resonant frequency, which is measured and correlated with the change in IOP. The electrically conductive coil is adapted to be worn by the subject and may be mounted on a pair of glasses.

公开(公告)号：US12116399B2

公开(公告)日：2024-10-15

申请号：US16760206

申请日：2018-11-01

申请人： QUEEN'S UNIVERSITY AT KINGSTON ,  KINGSTON HEALTH SCIENCES CENTRE ,  EMORY UNIVERSITY ,  GEORGIA TECH RESEARCH CORPORATION

发明人： Philip Zakas ,  David Lillicrap ,  Christopher Doering ,  Eric Gaucher ,  Caelan Radford ,  Harold Trent Spencer

IPC分类号： C07K14/745 ,  A61K38/36 ,  A61P7/04 ,  C07K14/755 ,  C12N15/86 ,  A61K38/00

CPC分类号： C07K14/755 ,  A61P7/04 ,  C12N15/86 ,  A61K38/00 ,  C12N2740/10043

摘要： A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.

公开(公告)号：US20240329025A1

公开(公告)日：2024-10-03

申请号：US18619477

申请日：2024-03-28

申请人： Queen's University at Kingston

发明人： Zhe She ,  Sarah Jane Odessa Payne ,  Yu Pei

IPC分类号： G01N33/18 ,  G01N27/30

CPC分类号： G01N33/1813 ,  G01N27/301

摘要： Methods and apparatus for analyzing water use a plurality of working electrodes and at least one counter electrode adapted to be in contact with the water, and a source of electrical potential difference that simultaneously applies to each of the plurality of working electrodes a different potential selected from at least one range of potentials. A multichannel device obtains chronoamperometry measurements from the plurality of working electrodes. The chronoamperometry measurements are used to generate a pattern of electrical charge on the plurality of electrodes, and the pattern of electrical charge is correlated with one or more known patterns to perform one or more of: identify one or more analytes in the water, perform speciation of analytes, and determine one or more concentration of the one or more analytes in the water.

公开(公告)号：US20240173741A1

公开(公告)日：2024-05-30

申请号：US18384444

申请日：2023-10-27

申请人： Queen's University at Kingston

发明人： Cathleen M. Crudden ,  J. Hugh Horton ,  Olena V. Zenkina ,  Iraklii I. Ebralidze ,  Christene Anne Smith

IPC分类号： B05D1/18 ,  B32B15/04 ,  G01N21/552

CPC分类号： B05D1/18 ,  B32B15/04 ,  G01N21/554 ,  B32B2457/00

摘要： The present application provides stable, carbene-functionalized composite materials, and methods and uses thereof. These carbene-functionalized composite materials comprise a material having a metal surface, and a carbene monolayer that is uniform, contaminant-free (metal oxide, etc), and more stable than thiol-functionalized monolayers. Uses of such carbene-functionalized composite materials include semi-conducting materials, microelectronic devices, drug delivery or sensing applications.

公开(公告)号：US20240110250A1

公开(公告)日：2024-04-04

申请号：US18537520

申请日：2023-12-12

申请人： QUEEN'S UNIVERSITY AT KINGSTON ,  KINGSTON HEALTH SCIENCES CENTRE

发明人： Jeremy A. Squire ,  Maisa Yoshimoto

IPC分类号： C12Q1/6886 ,  C12Q1/6841

CPC分类号： C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/156 ,  C12Q2600/16

摘要： Methods, probe sets, kits, and compositions for gene deletion assays are disclosed. In some embodiments, the methods relate to preparing probes for a deletion assay, performing a deletion assay, or optimizing a deletion assay. In some embodiments, the methods and probe sets can provide reduced artifactual deletion frequency, for example, when analyzing samples subject to truncation artifacts. In some embodiments, the methods and probe sets can distinguish between small and large deletions.

公开(公告)号：US11547325B2

公开(公告)日：2023-01-10

申请号：US16408656

申请日：2019-05-10

申请人： Queen's University at Kingston

发明人： Stephen H. Scott ,  Kayne Park

IPC分类号： A61B5/11 ,  A61B5/16 ,  A61B5/00

摘要： A method and apparatus for quantifying differences in human sensorimotor performance useful for diagnosing, assessing, and/or detecting brain injury and/or a neurological disorder, or identifying exceptional performance in a subject. In a task a subject's limb movement is restricted to a limited workspace and an object moves towards the limb. The objective of the task is for the subject to contact the object with the limb within a set time period. During the task a perturbation directed to the object and/or limb, or other feature of the environment, may occur on some trials, requiring a rapid motor correction in order to contact the object, or the subject may receive an alternative instruction on whether to interact with the object. Position data and/or motion data and/or kinetic data of the limb or portions thereof with respect to a presented object are obtained, and a data set is acquired for a plurality of trials. The acquired data set provides information about brain injury and/or a neurological disorder in the subject or exceptional capabilities of the subject.

公开(公告)号：US20220368238A1

公开(公告)日：2022-11-17

申请号：US17742846

申请日：2022-05-12

申请人： Queen's University at Kingston

发明人： Yan-Fei Liu ,  Yang Chen ,  Binghui He ,  Wenbo Liu ,  Bo Sheng

IPC分类号： H02M3/335

摘要： A control circuit for an isolated power converter includes a first sensing circuit that senses a secondary side output voltage and produces a pulse wave modulation (PWM) signal having a duty cycle that is proportional to a value of the secondary side output voltage. The PWM is transferred across the converter isolation barrier to the primary side, and a primary side circuit receives the PWM signal and outputs a control signal. A controller determines the value of the secondary side output voltage from the control signal and uses the value to control primary side power switching devices of the isolated power converter to regulate the secondary side output voltage at a selected value.

公开(公告)号：US11492366B2

公开(公告)日：2022-11-08

申请号：US16761310

申请日：2018-11-06

申请人： QUEEN'S UNIVERSITY AT KINGSTON ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Caitlin Miron ,  Anne Petitjean ,  Jean-Louis Mergny

IPC分类号： C07F15/00 ,  A61P35/00 ,  A61K31/555 ,  A61K31/728 ,  A61K38/17 ,  A61K38/36 ,  A61K38/38 ,  A61K39/395 ,  G01N33/52 ,  C07F13/00 ,  C07F11/00

摘要： Compounds are described and characterized that bind guanine quadruplexes of DNA or RNA. Binding data and inhibition of growth data of five cancer cell lines are presented.

公开(公告)号：US20220218202A1

公开(公告)日：2022-07-14

申请号：US17614157

申请日：2020-05-29

申请人： Queen's University at Kingston ,  Kingston Health Sciences Centre

发明人： Angelica Campigotto ,  Yong Jun Lai ,  Robert J. Campbell ,  Stephane Leahy

IPC分类号： A61B3/16 ,  A61B5/00 ,  G16H50/30 ,  G02C7/04

摘要： A device for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject includes a flexible lens that fits on the eye and changes curvature in response to a change in curvature of the eye. A microchannel disposed in or on the lens has one or more ends that are open to the atmosphere and an indicator solution is disposed in a portion of the 5 microchannel. The microchannel exhibits a change in volume in response to a change in curvature of the lens, which results in a change in position of the indicator solution in the microchannel. The change in position of the indicator solution in the microchannel is indicative of a change in IOP. The change in position of the indicator solution may be detected in digital images of the lens taken with a camera of a mobile electronic device such 0 as a smartphone or a camera worn by the subject.