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34 条记录 (耗时 0.018 秒)

    Cyclic implant perfusion, cleaning and passivation process and implant produced thereby
    2.
    发明授权
    Cyclic implant perfusion, cleaning and passivation process and implant produced thereby 有权
    循环植入物灌注，清洁和钝化过程以及由此产生的植入物

    公开(公告)号：US08142991B2

    公开(公告)日：2012-03-27

    申请号：US12389124

    申请日：2009-02-19

    申请人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

    发明人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

    IPC分类号： A01N1/02 ,  A61L2/18 ,  A61F2/00 ,  A61F2/28

    CPC分类号： A01N1/0289 ,  A61L2/0088 ,  A61L2/025

    摘要： This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.

    摘要翻译： 本发明是一种用于灌注多孔植入物的新方法，其实现期望因子的有效相互渗透和植入物的孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活 ，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。 该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。 该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少 植入抗原性。

    Materials and methods for improved bone tendon bone transplantation
    3.
    发明授权
    Materials and methods for improved bone tendon bone transplantation 有权
    改善骨腱骨移植的材料和方法

    公开(公告)号：US08110001B2

    公开(公告)日：2012-02-07

    申请号：US12563830

    申请日：2009-09-21

    申请人： Kevin C. Carter ,  Diane Carter, legal representative ,  Richard Ferguson

    发明人： Kevin C. Carter ,  Richard Ferguson

    IPC分类号： A61F2/08

    CPC分类号： A61F2/0811 ,  A61B17/1635 ,  A61B17/1637 ,  A61B2217/007 ,  A61F2/08 ,  A61F2002/0829 ,  A61F2002/0858 ,  A61F2002/087 ,  A61F2002/0882 ,  A61F2002/2839 ,  A61F2002/4649

    摘要： Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a porcine bone tendon bone graft for use in orthopedic procedures. Also disclosed are multiple embodiments of assembled bone tendon bone blocks for use in orthopedic surgeries. Additionally, a method of harvesting grafts that has improved efficiency, increases the quantity of extracted tissue and minimizes time required by surgeon for implantation is disclosed.

    摘要翻译： 本文公开了一种用于矫形外科手术的改进的骨腱骨移植物。 具体举例说明的是一种骨腱骨移植物，其包括一个或多个骨块，所述骨块具有切入其表面的凹槽，其中所述凹槽足以容纳固定螺钉。 还公开了用于矫形手术的猪骨腱骨移植物。 还公开了用于矫形外科手术的组合骨腱骨块的多个实施例。 此外，公开了一种收获具有改善效率的移植物的方法，增加提取的组织的量并且最小化外科医生用于植入所需的时间。

    Assembled bone-tendon-bone grafts
    5.
    发明授权
    Assembled bone-tendon-bone grafts 有权
    组织骨腱骨移植

    公开(公告)号：US07776089B2

    公开(公告)日：2010-08-17

    申请号：US11073281

    申请日：2005-03-04

    申请人： John R. Bianchi ,  Wesley I. Lewis ,  Joe Kutsavage ,  Dan Urbaniak ,  Angela Carr ,  Glenn C. Klein ,  Ben R. Sanders

    发明人： John R. Bianchi ,  Wesley I. Lewis ,  Joe Kutsavage ,  Dan Urbaniak ,  Angela Carr ,  Glenn C. Klein ,  Ben R. Sanders

    IPC分类号： A61F2/08

    CPC分类号： A61F2/0811 ,  A61F2/08 ,  A61F2002/087 ,  A61F2002/2839 ,  A61F2002/30057

    摘要： The present invention has multiple aspects. In its simplest aspect, the present invention is directed to an intermediate bone block comprising a machined segment of cortical bone, cancellous bone or both, the intermediate having a face comprising one to ten compression surfaces and one to ten cavities, the compression surfaces suitable for compressing soft tissue, the cavities for receiving and holding overflow soft tissue. The cavities are preferably channels, and more preferably channels having an omega cross-sectional profile. The invention is also directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particularly preferred graft is a bone-tendon-bone graft.

    摘要翻译： 本发明具有多个方面。 在其最简单的方面，本发明涉及一种中间骨块，其包括皮质骨，松质骨或两者的加工部分，所述中间体具有包括1至10个压缩表面和1至10个腔的表面，所述压缩表面适于 压缩软组织，用于接收和保持溢流软组织的空腔。 空腔优选为通道，更优选具有Ω形横截面轮廓的通道。 本发明还涉及适于结合软组织以形成可植入移植物的骨块组合物，以及这种可植入移植物。 特别优选的移植物是骨 - 肌 - 骨移植物。