公开(公告)号：US08440632B2

公开(公告)日：2013-05-14

申请号：US12863979

申请日：2009-01-23

申请人： Thomas E. Daley ,  Michael Tempesta

发明人： Thomas E. Daley ,  Michael Tempesta

IPC分类号： A61K31/70 ,  C07J41/00

CPC分类号： A61K31/704 ,  A61K31/198 ,  A61K31/357 ,  A61K2300/00

摘要： Provided herein are ginsenoside compositions comprising at least 10% (w/w) of a protopanaxadiol type of ginsenoside suitable for administration to a subject. Also provided are methods using the ginsenoside compositions for reducing acetaldehyde concentrations, preventing or ameliorating a symptom of elevated acetaldehyde concentration, or reducing the risk of diseases or disorders caused by the intake of ethyl alcohol.

摘要翻译： 本文提供的人参皂甙组合物包含至少10％（w / w）的原人参二醇类型的人参皂甙适用于给予受试者。 还提供了使用人参皂苷组合物降低乙醛浓度，预防或改善乙醛浓度升高的症状或降低由摄入乙醇引起的疾病或障碍的风险的方法。

公开(公告)号：US20120322843A1

公开(公告)日：2012-12-20

申请号：US13529695

申请日：2012-06-21

申请人： Thomas E. Daley ,  Elizabeth C. Squiers ,  Kin-Hung Peony Yu

发明人： Thomas E. Daley ,  Elizabeth C. Squiers ,  Kin-Hung Peony Yu

IPC分类号： A61K31/415 ,  A61P1/12 ,  A61P1/08

CPC分类号： A61K31/415 ,  A61K9/0053

摘要： Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of genetic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydrogenase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these subpopulations.

摘要翻译： 本文提供了向表达醇脱氢酶和醛脱氢酶基因的特定多态性的遗传亚群体的受试者施用4-甲基吡唑（4-MP）或其生理上可接受的盐的方法。 本文还提供了防止或改善乙醇不耐受，减少或改善伴随乙醇消耗的乙醛积聚相关症状或降低由消耗乙醇引起的疾病或障碍的风险的方法，包括给予4-MP或其生理学上可接受的盐， 对这些亚群体的受试者。